Author | Theo Colborn Dianne Dumanoski John Peterson Myers |
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Country | United States |
Language | English |
Subject | Endocrine disruptors, public health |
Publisher | Dutton |
Publication date | 1996 |
Pages | 306 |
ISBN | 978-0-525-93982-5 |
OCLC | 33246122 |
LC Class | RA1224.2.C65 |
Our Stolen Future: Are We Threatening Our Fertility, Intelligence, and Survival? A Scientific Detective Story is a 1996 book by Theo Colborn, Dianne Dumanoski, and John Peterson Myers. The book chronicles the development of the endocrine disruptor hypothesis by Colborn. Though written for the popular press in narrative form, the book contains a substantial amount of scientific evidence. A foreword from then Vice President Al Gore increased the book's visibility. It ultimately influenced government policy through congressional hearings and helped foster the development of a research and regulation initiative within the United States Environmental Protection Agency (EPA).
The authors also started a website which continues to monitor and report on endocrine disruptor scientific research.
Thousands of scientific articles have since been published on endocrine disruption, demonstrating the availability of grant money for research on the hypothesis raised by Our Stolen Future. For example, a symposium at the 2007 American Association for the Advancement of Science (AAAS) meeting explored the contribution of endocrine disruption to obesity and metabolic disorder. As is often the case, there is strong animal evidence but few epidemiological tests of predictions based on the animal experiments. [1]
A 2006 analysis of Center for Disease Control (CDC) data found an extraordinary increase in risk to type II diabetes as a function of exposure to persistent organic pollutants (POPs), in particular synthetic organic chemicals such as organohalogens. [2]
Sewage sludge is the residual, semi-solid material that is produced as a by-product during sewage treatment of industrial or municipal wastewater. The term "septage" also refers to sludge from simple wastewater treatment but is connected to simple on-site sanitation systems, such as septic tanks.
Chlordane, or chlordan, is an organochlorine compound that was used as a pesticide. It is a white solid. In the United States, chlordane was used for termite-treatment of approximately 30 million homes until it was banned in 1988. Chlordane was banned 10 years earlier for food crops like corn and citrus, and on lawns and domestic gardens.
Water pollution is the contamination of water bodies, usually as a result of human activities, so that it negatively affects its uses. Water bodies include lakes, rivers, oceans, aquifers, reservoirs and groundwater. Water pollution results when contaminants mix with these water bodies. Contaminants can come from one of four main sources: sewage discharges, industrial activities, agricultural activities, and urban runoff including stormwater. Water pollution is either surface water pollution or groundwater pollution. This form of pollution can lead to many problems, such as the degradation of aquatic ecosystems or spreading water-borne diseases when people use polluted water for drinking or irrigation. Another problem is that water pollution reduces the ecosystem services that the water resource would otherwise provide.
Phthalates, or phthalate esters, are esters of phthalic acid. They are mainly used as plasticizers, i.e., substances added to plastics to increase their flexibility, transparency, durability, and longevity. They are used primarily to soften polyvinyl chloride (PVC). Note that while phthalates are usually plasticizers, not all plasticizers are phthalates. The two terms are specific and unique and cannot be used interchangeably.
Lindane, also known as gamma-hexachlorocyclohexane (γ-HCH), gammaxene, Gammallin and benzene hexachloride (BHC), is an organochlorine chemical and an isomer of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical treatment for lice and scabies.
Perfluorooctanesulfonic acid (PFOS) is a chemical compound having an eight-carbon fluorocarbon chain and a sulfonic acid functional group and thus a perfluorosulfonic acid. It is an anthropogenic (man-made) fluorosurfactant, now regarded as a global pollutant. PFOS was the key ingredient in Scotchgard, a fabric protector made by 3M, and related stain repellents. The acronym "PFOS" refers to the parent sulfonic acid and to various salts of perfluorooctanesulfonate. These are all colorless or white, water-soluble solids. Although of low acute toxicity, PFOS has attracted much attention for its pervasiveness and environmental impact. It was added to Annex B of the Stockholm Convention on Persistent Organic Pollutants in May 2009.
Endocrine disruptors, sometimes also referred to as hormonally active agents, endocrine disrupting chemicals, or endocrine disrupting compounds are chemicals that can interfere with endocrine systems. These disruptions can cause numerous adverse human health outcomes including, alterations in sperm quality and fertility, abnormalities in sex organs, endometriosis, early puberty, altered nervous system function, immune function, certain cancers, respiratory problems, metabolic issues, diabetes, obesity, cardiovascular problems, growth, neurological and learning disabilities, and more. Found in many household and industrial products, endocrine disruptors "interfere with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for development, behavior, fertility, and maintenance of homeostasis ."
Persistent organic pollutants (POPs) are organic compounds that are resistant to degradation through chemical, biological, and photolytic processes. They are toxic chemicals that adversely affect human health and the environment around the world. Because they can be transported by wind and water, most POPs generated in one country can and do affect people and wildlife far from where they are used and released.
Xenoestrogens are a type of xenohormone that imitates estrogen. They can be either synthetic or natural chemical compounds. Synthetic xenoestrogens include some widely used industrial compounds, such as PCBs, BPA, and phthalates, which have estrogenic effects on a living organism even though they differ chemically from the estrogenic substances produced internally by the endocrine system of any organism. Natural xenoestrogens include phytoestrogens which are plant-derived xenoestrogens. Because the primary route of exposure to these compounds is by consumption of phytoestrogenic plants, they are sometimes called "dietary estrogens". Mycoestrogens, estrogenic substances from fungi, are another type of xenoestrogen that are also considered mycotoxins.
Endosulfan is an off-patent organochlorine insecticide and acaricide that is being phased out globally. It became a highly controversial agrichemical due to its acute toxicity, potential for bioaccumulation, and role as an endocrine disruptor. Because of its threats to human health and the environment, a global ban on the manufacture and use of endosulfan was negotiated under the Stockholm Convention in April 2011. The ban took effect in mid-2012, with certain uses exempted for five additional years. More than 80 countries, including the European Union, Australia, New Zealand, several West African nations, the United States, Brazil, and Canada had already banned it or announced phase-outs by the time the Stockholm Convention ban was agreed upon. It is still used extensively in India and China despite laws against its use. It is also used in a few other countries. It is produced by the Israeli firm Makhteshim Agan and several manufacturers in India and China. On 13.05.2011, the India Supreme Court ordered a ban on the production and sale of endosulfan in India, pending further notice.
Endrin is an organochlorine compound with the chemical formula C12H8Cl6O that was first produced in 1950 by Shell and Velsicol Chemical Corporation. It was primarily used as an insecticide, as well as a rodenticide and piscicide. It is a colourless, odorless solid, although commercial samples are often off-white. Endrin was manufactured as an emulsifiable solution known commercially as Endrex. The compound became infamous as a persistent organic pollutant and for this reason it is banned in many countries.
Theodora Emily Colborn was Founder and President Emerita of The Endocrine Disruption Exchange (TEDX), based in Paonia, Colorado, and Professor Emerita of Zoology at the University of Florida, Gainesville. She was an environmental health analyst, and best known for her studies on the health effects of endocrine disrupting chemicals. She died in 2014.
Methoxychlor is a synthetic organochloride insecticide, now obsolete. Tradenames for methoxychlor include Chemform, Maralate, Methoxo, Methoxcide, Metox, and Moxie.
Air pollution is the contamination of air due to the presence of substances called pollutants in the atmosphere that are harmful to the health of humans and other living beings, or cause damage to the climate or to materials. It is also the contamination of the indoor or outdoor environment either by chemical, physical, or biological agents that alters the natural features of the atmosphere. There are many different types of air pollutants, such as gases, particulates, and biological molecules. Air pollution can cause diseases, allergies, and even death to humans; it can also cause harm to other living organisms such as animals and crops, and may damage the natural environment or built environment. Air pollution can be caused by both human activities and natural phenomena.
Thomas Jakl is the former chair of the European Chemicals Agency's Management board and is Deputy Director General of the Austrian Environment Ministry responsible for Chemicals Policy. His field of activity includes legislation on chemical substances at the national, European and UN levels. He served as ECHA's president from 2008 until September 2012. He is president of the Governing Board of PARC - the "Partnership for Risk Assessment for Chemicals" a 400 Million Euro initiative of the EU's research program "Horizon Europe".
Health effects of pesticides may be acute or delayed in those who are exposed. Acute effects can include pesticide poisoning, which may be a medical emergency. Strong evidence exists for other, long-term negative health outcomes from pesticide exposure including birth defects, fetal death, neurodevelopmental disorder, cancer, and neurologic illness including Parkinson's disease. Toxicity of pesticides depend on the type of chemical, route of exposure, dosage, and timing of exposure.
Sex is influenced by water pollutants that are encountered in everyday life. These sources of water can range from the simplicity of a water fountain to the entirety of the oceans. The pollutants within the water range from endocrine disruptor chemicals (EDCs) in birth control to Bisphenol A (BPA). Foreign substances such as chemical pollutants that cause an alteration of sex have been found in growing prevalence in the circulating waters of the world. These pollutants have affected not only humans, but also animals in contact with the pollutants.
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.
The Akwesasne Task Force on the Environment (ATFE) is a community-based grassroots activist organization developed to address issues of environmental justice and contamination within the Mohawk Nation of Akwesasne. The mission of the ATFE is to preserve the Mohawk community's spiritual, cultural and biological integrity through activism, advocacy, and collaborative research. They achieve their efforts through projects related to political advocacy, environmental education and by conducting culturally-sensitive research to address the consequences of environmental injustices. The ATFE's influence has extended to surrounding public schools and has contributed to discussions on the introduction of Indigenous Knowledge into mainstream science curricula in the United States.
Deborah Liebl Swackhamer was an environmental chemist and professor emerita at the University of Minnesota in Minneapolis. Swackhamer applied her expertise in studying the effects of exposure to toxic chemicals, as well as the processes that spread those chemicals, to developing policies that address exposure risks.
Some of the most important papers that support the opinions of the book's authors can be found here.