PRMT8

Last updated

Protein arginine methyltransferase 8 is a protein that in humans is encoded by the PRMT8 gene. [1] Arginine methylation is a posttranslational modification involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction and protein compartmentalization. [1] PRMT8 binds and dimethylates Ewing sarcoma breakpoint region 1 (EWS) protein. [2]

Contents

Model organisms

Model organisms have been used in the study of PRMT8 function. A conditional knockout mouse line, called Prmt8tm1a(EUCOMM)Wtsi [7] [8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. [9] [10] [11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. [5] [12] Twenty four tests were carried out on homozygous mutant mice and one significant abnormality was observed: the animals had decreased IgG1 levels. [5]

Related Research Articles

<span class="mw-page-title-main">Lamin B2</span> Protein-coding gene in the species Homo sapiens

Lamin B2 is a protein that in humans is encoded by the LMNB2 gene. It is the second of two type B nuclear lamins, and it is associated with laminopathies.

<span class="mw-page-title-main">TRPC4AP</span> Protein-coding gene in the species Homo sapiens

Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.

<span class="mw-page-title-main">PRMT1</span> Protein-coding gene in the species Homo sapiens

Protein arginine N-methyltransferase 1 is an enzyme that in humans is encoded by the PRMT1 gene. The HRMT1L2 gene encodes a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4.

<span class="mw-page-title-main">Protein arginine methyltransferase 5</span> Protein-coding gene in the species Homo sapiens

Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene. PRMT5 symmetrically dimethylates H2AR3, H4R3, H3R2, and H3R8 in vivo, all of which are linked to a range of transcriptional regulatory events.

<span class="mw-page-title-main">SMYD3</span> Protein-coding gene in the species Homo sapiens

SET and MYND (myeloid-Nervy-DEAF-1) domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.

RhoU is a small signaling G protein, and is a member of the Rho family of GTPases. Wrch1 was identified in 2001 as encoded by a non-canonical Wnt induced gene. RhoU/Wrch delineates with RhoV/Chp a Rho subclass related to Rac and Cdc42, which emerged in early multicellular organisms during evolution.

<span class="mw-page-title-main">PRMT3</span> Protein-coding gene in the species Homo sapiens

Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene.

<span class="mw-page-title-main">MTRF1L</span> Protein-coding gene in the species Homo sapiens

Mitochondrial translational release factor 1-like is a protein that in humans is encoded by the MTRF1L gene.

<span class="mw-page-title-main">SLC41A3</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 41, member 3 is a protein that in humans is encoded by the SLC41A3 gene.

<span class="mw-page-title-main">CARMIL1</span> Protein-coding gene in the species Homo sapiens

CARMIL1 is a protein that in humans is encoded by the CARMIL1 gene. The gene is also known as LRRC16, LRRC16A, CARMIL, or CARMIL1a.

<span class="mw-page-title-main">NSUN2</span> Protein-coding gene in the species Homo sapiens

NOP2/Sun domain family, member 2 is a protein that in humans is encoded by the NSUN2 gene. Alternatively spliced transcript variants encoding different isoforms have been noted for the gene.

<span class="mw-page-title-main">SEC24A</span> Protein-coding gene in the species Homo sapiens

SEC24 family, member A is a protein that in humans is encoded by the SEC24A gene. The protein belongs to a protein family that are homologous to yeast Sec24. It is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum.

Malignant Brain Tumor domain containing 1 is a protein that in humans is encoded by the MBTD1 gene. The gene is also known as SA49P01.

<span class="mw-page-title-main">DIP2B</span> Protein-coding gene in the species Homo sapiens

DIP2 disco-interacting protein 2 homolog B (Drosophila) is a protein that in humans is encoded by the DIP2B gene. A member of the disco-interacting protein homolog 2 protein family, it contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1, as well as AMP-binding sites. The presence of these sites suggests that DIP2B may participate in DNA methylation. This gene is located near a folate-sensitive fragile site.

Solute carrier family 25, member 29 is a protein that in humans is encoded by the SLC25A29 gene. The gene is also known as CACL and C14orf69. SLC25A29 belongs to a protein family of solute carriers called the mitochondrial carriers.

Protein arginine methyltransferase 7 is a protein that in humans is encoded by the PRMT7 gene. Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing.

Ankyrin repeat and sterile alpha motif domain containing 4B is a protein that in humans is encoded by the ANKS4B gene. The gene is also known as HARP. Ankyrin repeats mediate protein-protein interactions in very diverse families of proteins.

RNA (guanine-9-) methyltransferase domain containing 2 is a protein that in humans is encoded by the RG9MTD2 gene. The gene is also known as TRM10.

Family with sequence similarity 104, member A is a protein that in humans is encoded by the FAM104A gene. The orthologous gene in mice is also known as D11Wsu99e.

Zinc finger protein 367 is a protein that in humans is encoded by the ZNF367 gene. The human gene is also known as ZFF29 and CDC14B; the orthologue in mice is Zfp367. ZNF367 contains a unique Cys2His2 zinc finger motif and is a member of the zinc finger protein family.

References

  1. 1 2 "Protein arginine methyltransferase 8" . Retrieved 2011-12-04.
  2. Kim, J. D.; Kako, K.; Kakiuchi, M.; Park, G. G.; Fukamizu, A. (2008). "EWS is a substrate of type I protein arginine methyltransferase, PRMT8". International Journal of Molecular Medicine. 22 (3): 309–315. PMID   18698489.
  3. "Salmonella infection data for Prmt8". Wellcome Trust Sanger Institute.
  4. "Citrobacter infection data for Prmt8". Wellcome Trust Sanger Institute.
  5. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID   85911512.
  6. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. "International Knockout Mouse Consortium".
  8. "Mouse Genome Informatics".
  9. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC   3572410 . PMID   21677750.
  10. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a . PMID   21677718.
  11. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018 . PMID   17218247. S2CID   18872015.
  12. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC   3218837 . PMID   21722353.

Further reading