PTENP1

PTENP1
Identifiers
Aliases	PTENP1 , PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN, phosphatase and tensin homolog pseudogene 1
External IDs	OMIM: 613531 GeneCards: PTENP1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	33,677,499 bp
Orthologs
	11191
	n/a
	ENSG00000237984
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated January 28, 2024

Phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1, also known as PTENP1, is a human pseudogene.^[3] which has a partial reactivated function as a competing endogenous RNA regulating the tumor suppressor gene PTEN.^[4]

Related Research Articles

<i>PTEN</i> (gene) Tumor suppressor gene

Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available.

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.

Deleted in malignant brain tumors 1 protein is a protein that in humans is encoded by the DMBT1 gene.

DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.

<span class="mw-page-title-main">SNAI1</span> Protein

Zinc finger protein SNAI1 is a protein that in humans is encoded by the SNAI1 gene. Snail is a family of transcription factors that promote the repression of the adhesion molecule E-cadherin to regulate epithelial to mesenchymal transition (EMT) during embryonic development.

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.

MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.

SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. It was originally isolated in Drosophila melanogaster in a pathway (also known as the Scribble complex) with DLGAP5 (Discs large) and LLGL1 (Lethal giant larvae) as a tumor suppressor. In humans, SCRIB is found as a membrane protein and is involved in cell migration, cell polarity, and cell proliferation in epithelial cells. There is also strong evidence that SCRIB may play a role in cancer progression because of its strong homology to the Drosophila protein.

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.

Zinc finger MYND domain-containing protein 10 is a protein that in humans is encoded by the ZMYND10 gene.

CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed in many tissues and cell types. The gene codes for two proteins, including the INK4 family member p16 and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits cyclin dependent kinases 4 and 6 and thereby activates the retinoblastoma (Rb) family of proteins, which block traversal from G1 to S-phase. p14ARF activates the p53 tumor suppressor. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53. Germline mutations of CDKN2A are associated with familial melanoma, glioblastoma and pancreatic cancer. The CDKN2A gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.

Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.

Protein CIP2A also known as cancerous inhibitor of PP2A (CIP2A) is a protein that in humans is encoded by the KIAA1524 gene.

Tensin-4 is a protein that in humans is encoded by the TNS4 gene.

Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.

Matrix-remodelling associated 5 is a protein in humans that is encoded by the MXRA5 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000237984 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PTENP1 phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1".
↑ Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP (June 2010). "A coding-independent function of gene and pseudogene mRNAs regulates tumour biology". Nature. 465 (7301): 1033–8. Bibcode:2010Natur.465.1033P. doi:10.1038/nature09144. PMC 3206313 . PMID 20577206.*Lay summary in: Buehler J (September 1, 2021). "The Complex Truth About 'Junk DNA'". Quanta Magazine.

Kong D, Suzuki A, Zou TT, Sakurada A, Kemp LW, Wakatsuki S, Yokoyama T, Yamakawa H, Furukawa T, Sato M, Ohuchi N, Sato S, Yin J, Wang S, Abraham JM, Souza RF, Smolinski KN, Meltzer SJ, Horii A (October 1997). "PTEN1 is frequently mutated in primary endometrial carcinomas". Nature Genetics. 17 (2): 143–4. doi:10.1038/ng1097-143. PMID 9326929. S2CID 29666790.
Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WK, Fujii G, Berson A, Steck PA (December 1997). "MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines". Cancer Research. 57 (23): 5221–5. PMID 9393738.
Sakurada A, Suzuki A, Sato M, Yamakawa H, Orikasa K, Uyeno S, Ono T, Ohuchi N, Fujimura S, Horii A (November 1997). "Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary". Japanese Journal of Cancer Research. 88 (11): 1025–8. doi:10.1111/j.1349-7006.1997.tb00324.x. PMC 5921310 . PMID 9439675.
Kim SK, Su LK, Oh Y, Kemp BL, Hong WK, Mao L (January 1998). "Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines". Oncogene. 16 (1): 89–93. doi: 10.1038/sj.onc.1201512 . PMID 9467947.
Dahia PL, FitzGerald MG, Zhang X, Marsh DJ, Zheng Z, Pietsch T, von Deimling A, Haluska FG, Haber DA, Eng C (May 1998). "A highly conserved processed PTEN pseudogene is located on chromosome band 9p21". Oncogene. 16 (18): 2403–6. doi:10.1038/sj.onc.1201762. PMID 9620558. S2CID 33570502.
Forgacs E, Biesterveld EJ, Sekido Y, Fong K, Muneer S, Wistuba II, Milchgrub S, Brezinschek R, Virmani A, Gazdar AF, Minna JD (September 1998). "Mutation analysis of the PTEN/MMAC1 gene in lung cancer". Oncogene. 17 (12): 1557–65. doi: 10.1038/sj.onc.1202070 . PMID 9794233. S2CID 24423191.
Fujii GH, Morimoto AM, Berson AE, Bolen JB (March 1999). "Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN". Oncogene. 18 (9): 1765–9. doi:10.1038/sj.onc.1202492. PMID 10208437. S2CID 5938219.
Trojan J, Plotz G, Brieger A, Raedle J, Meltzer SJ, Wolter M, Zeuzem S (December 2001). "Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease". The Journal of Investigative Dermatology. 117 (6): 1650–3. doi: 10.1046/j.0022-202x.2001.01954.x . PMID 11886535.

This protein-related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000237984 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: PTENP1 phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1".

[4] Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP (June 2010). "A coding-independent function of gene and pseudogene mRNAs regulates tumour biology". Nature. 465 (7301): 1033–8. Bibcode:2010Natur.465.1033P. doi:10.1038/nature09144. PMC 3206313 . PMID 20577206.*Lay summary in: Buehler J (September 1, 2021). "The Complex Truth About 'Junk DNA'". Quanta Magazine.

[1]

[2]

[3]

[4]

PTENP1

Related Research Articles

References

Further reading