Peter Rutledge

Last updated

Peter J. Rutledge
Nationality New Zealand
Citizenship Australian New Zealand
Alma mater University of Auckland
University of Oxford
Scientific career
Fields Organic chemistry
Drug discovery
Institutions Magdalen College, Oxford
Somerville College, Oxford
University of Oxford
University College Dublin
University of Sydney
Doctoral advisor Jack Edward Baldwin
Website Rutledge Research Group

Peter Jonathan Rutledge is a New Zealand chemist and professor at the School of Chemistry, University of Sydney. His research has focused on drug development for tuberculosis, [1] [2] [3] [4] antibiotics, [5] and metal sensing. [6] [7] [8] [9] He has engaged in some research activity on catalysis. [10] [11]

Contents

Education

Rutledge received his BSc in chemistry and biochemistry from the University of Auckland in 1993. He received his MSc from the same institution with first class honours in chemistry in 1995. He left New Zealand in 1995 and obtained his DPhil at Magdalen College, Oxford working with Jack Edward Baldwin in 1999. He was a postdoctoral research fellow at the same institution until 2003. [12] [13]

Career and research

Rutledge has held college lectureships at Magdalen College, Oxford, from 2000 to 2001 and Somerville College, Oxford, from 2001 to 2002. In 2003, he moved to become a lecturer at the Centre for Synthesis and Chemical Biology at University College Dublin. In 2006, he relocated to the University of Sydney and was an associate professor during the years 2014 to 2019. In 2019, he was promoted to a full professor of chemistry. [14] At the University of Sydney, Rutledge regularly collaborated with the group of Matthew H. Todd until his departure to University College London in 2018. [15] [16] [17] [18] [19] [20] [21]

Honours and awards

References

  1. ↑ Guardia, Ana; Baiget, Jessica; Cacho, Mónica; Pérez, Arancha; Ortega-Guerra, Montserrat; Nxumalo, Winston; Khanye, Setshaba D.; Rullas, Joaquín; Ortega, Fátima; Jiménez, Elena; Pérez-Herrán, Esther; Fraile-Gabaldón, María Teresa; Esquivias, Jorge; Fernández, Raquel; Porras-De Francisco, Esther; Encinas, Lourdes; Alonso, Marta; Giordano, Ilaria; Rivero, Cristina; Miguel-Siles, Juan; Osende, Javier G.; Badiola, Katrina A.; Rutledge, Peter J.; Todd, Matthew H.; Remuiñán, Modesto; Alemparte, Carlos (2018). "Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis" . Journal of Medicinal Chemistry. 61 (24): 11327–11340. doi:10.1021/acs.jmedchem.8b01533. PMID   30457865.
  2. ↑ Yu, Mingfeng; Nagalingam, Gayathri; Ellis, Samantha; Martinez, Elena; Sintchenko, Vitali; Spain, Malcolm; Rutledge, Peter J.; Todd, Matthew H.; Triccas, James A. (2016). "Nontoxic Metal–Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis". Journal of Medicinal Chemistry. 59 (12): 5917–5921. doi:10.1021/acs.jmedchem.6b00432. hdl: 2123/22237 . PMID   27214150.
  3. ↑ Manos-Turvey, Alexandra; Bulloch, Esther M. M.; Rutledge, Peter J.; Baker, Edward N.; Lott, J. Shaun; Payne, Richard J. (2010). "Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI)". ChemMedChem. 5 (7): 1067–1079. doi:10.1002/cmdc.201000137. PMID   20512795.
  4. ↑ Spain, Malcolm; Wong, Joseph K.-H.; Nagalingam, Gayathri; Batten, James M.; Hortle, Elinor; Oehlers, Stefan H.; Jiang, Xiao Fan; Murage, Hasini E.; Orford, Jack T.; Crisologo, Patrick; Triccas, James A.; Rutledge, Peter J.; Todd, Matthew H. (2018). "Antitubercular Bis-Substituted Cyclam Derivatives: Structure–Activity Relationships and in Vivo Studies". Journal of Medicinal Chemistry. 61 (8): 3595–3608. doi:10.1021/acs.jmedchem.7b01569. hdl: 2123/22236 . PMID   29558124.
  5. ↑ Devi, Prarthana; Rutledge, Peter J. (2017). "Cyclobutanone Analogues of β-Lactam Antibiotics: β-Lactamase Inhibitors with Untapped Potential?". ChemBioChem. 18 (4): 338–351. doi:10.1002/cbic.201600529. hdl: 2123/22242 . PMID   27992105.
  6. ↑ Lau, Yu Heng; Clegg, Jack K.; Price, Jason R.; Macquart, Rene B.; Todd, Matthew H.; Rutledge, Peter J. (2018). "Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands". Chemistry – A European Journal. 24 (7): 1573–1585. doi:10.1002/chem.201703488. hdl: 2123/20371 . PMID   29052259.
  7. ↑ Wong, Joseph; Todd, Matthew; Rutledge, Peter (25 January 2017). "Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing". Molecules. 22 (2): 200. doi: 10.3390/molecules22020200 . PMC   6155713 . PMID   28125069.
  8. ↑ Lau, Yu Heng; Price, Jason R.; Todd, Matthew H.; Rutledge, Peter J. (2011). "A Click Fluorophore Sensor that Can Distinguish CuII and HgII via Selective Anion-Induced Demetallation". Chemistry – A European Journal. 17 (10): 2850–2858. doi:10.1002/chem.201002477. PMID   21305620.
  9. ↑ Lau, Yu Heng; Rutledge, Peter J.; Watkinson, Michael; Todd, Matthew H. (2011). "Chemical sensors that incorporate click-derived triazoles". Chemical Society Reviews. 40 (5): 2848–66. doi:10.1039/C0CS00143K. PMID   21380414.
  10. ↑ Devi, Prarthana; Barry, Sarah M.; Houlihan, Kate M.; Murphy, Michael J.; Turner, Peter; Jensen, Paul; Rutledge, Peter J. (2015). "Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid". Scientific Reports. 5 (1): 9950. Bibcode:2015NatSR...5E9950D. doi:10.1038/srep09950. PMC   4424836 . PMID   25954918.
  11. ↑ Counsell, Andrew J; Jones, Angus T; Todd, Matthew H; Rutledge, Peter J (2016). "A direct method for the N-tetraalkylation of azamacrocycles". Beilstein Journal of Organic Chemistry. 12: 2457–2461. doi:10.3762/bjoc.12.239. PMC   5238601 . PMID   28144313.
  12. ↑ "Rutledge Research Group - People". sydney.edu.au. Retrieved 3 August 2019.
  13. ↑ "Professor Peter Rutledge - The University of Sydney". sydney.edu.au. University of Sydney. Retrieved 3 August 2019.
  14. ↑ Sydney, The University of. "Professor Peter Rutledge - The University of Sydney". sydney.edu.au.
  15. ↑ Spain, Malcolm; Wong, Joseph K.-H.; Nagalingam, Gayathri; Batten, James M.; Hortle, Elinor; Oehlers, Stefan H.; Jiang, Xiao Fan; Murage, Hasini E.; Orford, Jack T.; Crisologo, Patrick; Triccas, James A.; Rutledge, Peter J.; Todd, Matthew H. (2018). "Antitubercular Bis-Substituted Cyclam Derivatives: Structure–Activity Relationships and in Vivo Studies". Journal of Medicinal Chemistry. 61 (8): 3595–3608. doi:10.1021/acs.jmedchem.7b01569. hdl: 2123/22236 . ISSN   0022-2623. PMID   29558124.
  16. ↑ Todd, Matthew H.; Watkinson, Michael; Rutledge, Peter J.; Lau, Yu Heng (2011). "Chemical sensors that incorporate click-derived triazoles". Chemical Society Reviews. 40 (5): 2848–2866. doi:10.1039/C0CS00143K. ISSN   1460-4744. PMID   21380414.
  17. ↑ Lau, Yu Heng; Price, Jason R.; Todd, Matthew H.; Rutledge, Peter J. (2011). "A Click Fluorophore Sensor that Can Distinguish CuII and HgII via Selective Anion-Induced Demetallation". Chemistry – A European Journal. 17 (10): 2850–2858. doi:10.1002/chem.201002477. ISSN   1521-3765. PMID   21305620.
  18. ↑ Ast, Sandra; Rutledge, Peter J.; Todd, Matthew H. (2012). "Reversing the Triazole Topology in a Cyclam-Triazole-Dye Ligand Gives a 10-Fold Brighter Signal Response to Zn2+ in Aqueous Solution". European Journal of Inorganic Chemistry. 2012 (34): 5611–5615. doi:10.1002/ejic.201201072. ISSN   1099-0682.
  19. ↑ Rutledge, Peter J.; Todd, Matthew H.; Turner, Peter; Tang, Cyril; Wong, Joseph K.-H.; Yu, Mingfeng (2015). "Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids". Beilstein Journal of Organic Chemistry. 11 (1): 37–41. doi:10.3762/bjoc.11.6. ISSN   1860-5397. PMC   4311716 . PMID   25670990.
  20. ↑ Wong, Joseph; Todd, Matthew; Rutledge, Peter (2017). "Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing". Molecules. 22 (2): 200. doi: 10.3390/molecules22020200 . ISSN   1420-3049. PMC   6155713 . PMID   28125069.
  21. ↑ Yu, Mingfeng; Yu, Qun; Rutledge, Peter J.; Todd, Matthew H. (2013). "A Fluorescent "Allosteric Scorpionand" Complex Visualizes a Biological Recognition Event" . ChemBioChem. 14 (2): 224–229. doi:10.1002/cbic.201200637. ISSN   1439-7633. PMID   23303717.
  22. ↑ "2012 Award Winners – The Royal Australian Chemical Institute". RACI. Retrieved 23 April 2019.
  23. ↑ "Teaching @ Sydney". University of Sydney. Retrieved 23 April 2019.
  24. ↑ "Dr Charlotte Taylor wins Learning and Teaching Citation". University of Sydney. Retrieved 23 April 2019.
  25. ↑ "Dr Peter Rutledge – AIPS". AIPS. Retrieved 23 April 2019.
  26. ↑ "RACI Annual Report". RACI. Retrieved 23 April 2019.
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