Placental site nodule

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Placental site nodule
Placental site nodule - intermed mag.jpg
Micrograph of a placental site nodule (top of image). H&E stain.

A placental site nodule (PSN) is benign remnant from a previous pregnancy. [1]

Contents

Presentation

They are typically asymptomatic and found incidentally. [1]

Pathology

PSNs are intermediate trophoblastic remnants.

Diagnosis

PSN are diagnosed by examining the tissue under a microscope, usually obtained with a dilation and curettage.

Typically, they consist of pink (hyaline) material using the standard stain and contain few cells. Bizarre multinucleated cells may be present; however, there is no mitotic activity. The differential diagnosis includes (cervical) squamous cell carcinoma, gestational trophoblastic disease, and exaggerated placental site.

Prognosis

PSN are benign. Once removed, they do not require any treatment and do not recur.

See also

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PSN is the PlayStation Network, an online service for Sony PlayStation game consoles.

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Placental site trophoblastic tumor

Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to arise from intermediate trophoblast.

Intermediate trophoblast

Intermediate trophoblast is a distinct subtype of trophoblastic tissue that arises from the cytotrophoblast.

Colloid nodule

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Epithelioid trophoblastic tumor (ETT) is a gestational trophoblastic disease with about 110 case reports in the literature. It is a trophoblastic tumor of neoplastic chorionic type associated with the intermediate trophoblast.

References

  1. 1 2 Jacob, S.; Mohapatra, D. (2009). "Placental site nodule: a tumor-like trophoblastic lesion". Indian J Pathol Microbiol. 52 (2): 240–1. doi: 10.4103/0377-4929.48931 . PMID   19332926.
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