Polyaminopropyl biguanide

This article is about polymer containing propyl linker between guanidine groups. For PHMB the antimicrobial polymer incorectly named Polyaminopropyl biguanide, see Polyhexanide.

Polyaminopropyl biguanide

Names
Other names Polyamine-propyl-biguanidine
Identifiers
CAS Number	133029-32-0  Y
Abbreviations	PAPB
ChemSpider	none
ECHA InfoCard	100.118.649
UNII	DT9D8Z79ET  Y
Properties
Chemical formula	(C5H11N5)n
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N  verify  (what is  YN ?) Infobox references

Polyaminopropyl biguanide (PAPB) is a polymer containing biguanide group connected with a three methylene (propyl) linker. The polymer is a propyl analogue of polyhexamethylene biguanide. The polymer display some antibacterial activity however much lower than PHMB. ^[1] As of May 2024, PAPB is not approved as a biocidal active substance under EU regulations. ^[2]

Name controversy

In some sources, particularly in lists of cosmetic ingredients (INCI), the name polyaminopropyl biguanide is wrongly associated with polyhexamethylene biguanide (PHMB) ^{[3] [4]}

References

1. Rembe, J.-D., Fromm-Dornieden, C., Schafer, N., Böhm, J. K., & Stuermer, E. K. (2016). Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. *Journal of Medical Microbiology*, 65(8), 867
2. European Chemicals Agency (ECHA). (n.d.). List of approved active substances. Retrieved May 24, 2024, from https://echa.europa.eu/regulations/biocidal-products-regulation/approval-of-active-substances/list-of-approved-active-substances
3. Cosmetic Ingredient Review Expert Panel (May 12, 2014). "Safety Assessment of Polyaminopropyl Biguanide as Used in Cosmetics" (PDF). Cosmetic Ingredient Review (CIR). Retrieved 2024-05-07.
4. Sukakul, Thanisorn; Dahlin, Jakob; Pontén, Ann; Antelmi, Annarita; Bruze, Magnus; Hamnerius, Nils; Hauksson, Inese; Isaksson, Marléne; Lejding, Tina; Svedman, Cecilia (2021). "Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide)". Contact Dermatitis. 84 (5): 326–331. doi:10.1111/cod.13728. PMC   8048451 . PMID   33098110.