In human embryonic development, a pre-embryo is a conceptus before implantation in the uterus. [1]
The word pre-embryo is sometimes used in ethical contexts to refer to a human conceptus at least between fertilization and implantation, though this term has not been adopted by the scientific community. [2] A conceptus between fertilization and implantation is also frequently classified as a pre-implantation embryo. [2]
Even after implantation begins, a pre-embryo may exist up until the formation of the primitive streak. [3] Implantation begins about six days after fertilization, and lasts for about a week, during which time formation of the primitive streak occurs. [4]
Use of the term pre-embryo, in the context of human development, has drawn criticism from opponents of embryo research. From scientists who have considered this categorization invalid or unnecessary. [1] [5] [6] One rationale that has been advanced for distinguishing an early fertilized human conceptus from an embryo is that there is a potential for the conceptus to split into identical twins prior to implantation, and so (the argument goes) the conceptus cannot be regarded before implantation as a single human being. However, the conceptus before implantation exhibits self-actuated activity, which has led to the assertion that it is an embryo. [7]
In the United States, a report by the National Institutes of Health stated that a conceptus could be both a pre-implantation embryo and a pre-embryo at the same time. [8] However, Ann Kiessling (a leader in stem cell research) has written that those categories are inaccurate. [9]
The illustration shows the ontological status of the preembryo, embryo, and fetus:
The colors represent the maternal and paternal genetic contributions.