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Aspergillus fumigatus is a species of fungus in the genus Aspergillus, and is one of the most common Aspergillus species to cause disease in individuals with an immunodeficiency.
Aspergillus is a genus consisting of a few hundred mould species found in various climates worldwide.
Mycoses are infectious diseases caused by pathogenic fungi. They include fungal infections of the skin, just under the skin and ones that are more deep or widespread such as histoplasmosis and blastomycosis. They include yeast infections such as candidiasis and pityriasis versicolor, and include several other opportunistic fungal infections such as aspergillosis and mucormycosis. Several, including sporotrichosis, chromoblastomycosis and mycetoma are neglected.
Galactomannans are polysaccharides consisting of a mannose backbone with galactose side groups (more specifically, a -linked beta-D-mannopyranose backbone with branchpoints from their 6-positions linked to alpha-D-galactose,.
Caspofungin (INN) is a lipopeptide antifungal drug from Merck & Co., Inc. discovered by James Balkovec, Regina Black and Frances A. Bouffard. It is a member of a new class of antifungals termed the echinocandins. It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall. Caspofungin was the first inhibitor of fungal (1→3)-β-D-glucan synthesis to be approved by the United States Food and Drug Administration. Caspofungin is administered intravenously.
Fungal pneumonia is an infection of the lungs by fungi. It can be caused by either endemic or opportunistic fungi or a combination of both. Case mortality in fungal pneumonias can be as high as 90% in immunocompromised patients, though immunocompetent patients generally respond well to anti-fungal therapy.
Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium. It can be taken by mouth or used by injection into a vein.
Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterised by an exaggerated response of the immune system to the fungus Aspergillus. It occurs most often in people with asthma or cystic fibrosis. Aspergillus spores are ubiquitous in soil and are commonly found in the sputum of healthy individuals. A. fumigatus is responsible for a spectrum of lung diseases known as aspergilloses.
Dolichocephaly is a condition where the head is longer than would be expected, relative to its width. In humans, scaphocephaly is a form of dolichocephaly.
Aspergillosis is a fungal infection of usually the lungs, caused by the genus Aspergillus, a common mold that is breathed in frequently from the air around, but does not usually affect most people. It generally occurs in people with lung diseases such as asthma, cystic fibrosis or tuberculosis, or those who have had a stem cell or organ transplant, and those who cannot fight infection because of medications they take such as steroids and some cancer treatments. Rarely, it can affect skin.
In radiology, the air crescent sign is a finding on chest radiograph and computed tomography that is crescenteric and radiolucent, due to a lung cavity that is filled with air and has a round radiopaque mass. Classically, it is due to an aspergilloma, a form of aspergillosis, that occurs when the fungus Aspergillus grows in a cavity in the lung. It is also referred as Monad sign.
Gliotoxin is a sulfur-containing mycotoxin that belongs to a class of naturally occurring 2,5-diketopiperazines produced by several species of fungi, especially those of marine origin. It is the most prominent member of the epipolythiopiperazines, a large class of natural products featuring a diketopiperazine with di- or polysulfide linkage. These highly bioactive compounds have been the subject of numerous studies aimed at new therapeutics. Gliotoxin was originally isolated from Gliocladium fimbriatum, and was named accordingly. It is an epipolythiodioxopiperazine metabolite.
Aspergillus terreus, also known as Aspergillus terrestris, is a fungus (mold) found worldwide in soil. Although thought to be strictly asexual until recently, A. terreus is now known to be capable of sexual reproduction. This saprotrophic fungus is prevalent in warmer climates such as tropical and subtropical regions. Aside from being located in soil, A. terreus has also been found in habitats such as decomposing vegetation and dust. A. terreus is commonly used in industry to produce important organic acids, such as itaconic acid and cis-aconitic acid, as well as enzymes, like xylanase. It was also the initial source for the drug mevinolin (lovastatin), a drug for lowering serum cholesterol.
Pentamycin, also called fungichromin, is a macrolide antimicrobial. Pentamycin is a polyene antifungal antibiotic obtained from Streptomyces pentaticus. It is used in the treatment of vaginal candidiasis, for the protozoal infection trichomoniasis, and mixed infections. A 3 mg vaginal pessary is inserted once or twice daily for 5-10 days. It is also used in Pulmonary Aspergillosis in a dry powder inhalation system.
Isavuconazonium sulfate, sold under the brand name Cresemba, is a systemic antifungal medication of the triazole class which is used to treat invasive aspergillosis and mucormycosis.
Mucormycosis, also known as black fungus, is a serious fungal infection, usually in people with reduced ability to fight infections. Symptoms depend on where in the body the infection occurs. It most commonly infects the sinuses and brain resulting in a runny nose, one-sided facial swelling and pain, headache, fever, and tissue death. Other forms of disease may infect the lungs, stomach and intestines, and skin.
Geotrichosis is a mycosis caused by Geotrichum candidum.
Chronic pulmonary aspergillosis is a long-term fungal infection caused by members of the genus Aspergillus—most commonly Aspergillusfumigatus. The term describes several disease presentations with considerable overlap, ranging from an aspergilloma—a clump of Aspergillus mold in the lungs—through to a subacute, invasive form known as chronic necrotizing pulmonary aspergillosis which affects people whose immune system is weakened. Many people affected by chronic pulmonary aspergillosis have an underlying lung disease, most commonly tuberculosis, allergic bronchopulmonary aspergillosis, asthma, or lung cancer.
Aspergillus chevalieri is a species of fungus in the genus Aspergillus. It is from the Aspergillus section. The fungi in the Aspergillus section are known for their ability to grow at extremely low water activities. The species was first described in 1926. It has since been reported as an opportunistic pathogen causing skin infections.
References
- ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.