Protein deacetylase

Last updated August 14, 2025

A protein deacetylase is any enzyme that removes acetyl groups from lysine amino acids in proteins.^[1]

The main ones are histone deacetylases (HDACs) and sirtuins (SIRT1,2,3,5).^[2]

Because histone proteins were the first known substrate for protein deacetylases, the latter all tend to be called HDACs of one class or another.^{[ citation needed ]}

Human protein deacetylase enzymes have been categorized into

Class I (HDAC1,2,3,8);
Class II (HDAC4,5,6,7,9,10),
Class III (SIRT1,2,3,5,6),
Class IV (HDAC11 and its related enzymes).

Class III are the NAD+-dependent protein deacetylases.

References

↑ Ito, Kazuhiro; Charron, Catherine E.; Adcock, Ian M. (November 2007). "Impact of protein acetylation in inflammatory lung diseases". Pharmacology & Therapeutics. 116 (2): 249–265. doi:10.1016/j.pharmthera.2007.06.009. PMID 17720252.
↑ Gupta, Rohan; Ambasta, Rashmi K.; Kumar, Pravir (January 2022). "Multifaced role of protein deacetylase sirtuins in neurodegenerative disease". Neuroscience & Biobehavioral Reviews. 132: 976–997. doi:10.1016/j.neubiorev.2021.10.047. PMID 34742724.

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[1] Ito, Kazuhiro; Charron, Catherine E.; Adcock, Ian M. (November 2007). "Impact of protein acetylation in inflammatory lung diseases". Pharmacology & Therapeutics. 116 (2): 249–265. doi:10.1016/j.pharmthera.2007.06.009. PMID 17720252.

[2] Gupta, Rohan; Ambasta, Rashmi K.; Kumar, Pravir (January 2022). "Multifaced role of protein deacetylase sirtuins in neurodegenerative disease". Neuroscience & Biobehavioral Reviews. 132: 976–997. doi:10.1016/j.neubiorev.2021.10.047. PMID 34742724.

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