Protein mimetic

Last updated June 20, 2025

A protein mimetic is a molecule such as a peptide, a modified peptide or any other molecule that biologically mimics the action or activity of some other protein. Protein mimetics are commonly used in drug design and discovery.^[1]

Types of mimetics

There are a number of different distinct classes of protein mimetics.

Antibody mimetic - Molecules that mimic antigen binding activity of antibodies.
Peptidomimetic - Small protein-like chains designed to mimic larger peptides.
Phosphomimetics - An amino acid substitution or modification which mimic the effect of protein phosphorylation.

References

↑ Robinson, John A.; DeMarco, Steve; Gombert, Frank; Moehle, Kerstin; Obrecht, Daniel (2008-11-01). "The design, structures and therapeutic potential of protein epitope mimetics" . Drug Discovery Today. 13 (21): 944–951. doi:10.1016/j.drudis.2008.07.008. ISSN 1359-6446.

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[1] Robinson, John A.; DeMarco, Steve; Gombert, Frank; Moehle, Kerstin; Obrecht, Daniel (2008-11-01). "The design, structures and therapeutic potential of protein epitope mimetics" . Drug Discovery Today. 13 (21): 944–951. doi:10.1016/j.drudis.2008.07.008. ISSN 1359-6446.

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Protein mimetic

Contents

Types of mimetics

See also

References