Pseudoprotease

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Comparison of Azurocidin 1 structure (pseudoprotease) to Chymotrypsin (functional protease) of same superfamily Azurocidin 1 structure.png
Comparison of Azurocidin 1 structure (pseudoprotease) to Chymotrypsin (functional protease) of same superfamily

Pseudoproteases are catalytically-deficient pseudoenzyme variants of proteases that are represented across the kingdoms of life. [1] [2]

Contents

Examples

Superfamilies containing pseudoenzymes with inactive triads [3]
Superfamily Families containing pseudoenzymesExamples
CA clan C1, C2, C19 Calpamodulin
CD clanC14 CFLAR
SC clanS9, S33 Neuroligin
SK clanS14 ClpR
SR clanS60Serotransferrin domain 2
ST clanS54 RHBDF1
PA clan S1 Azurocidin 1
PB clanT1 PSMB3

See also

References

  1. ↑ Fischer, Katja; Reynolds, Simone L. (2015-05-15). "Pseudoproteases: mechanisms and function" . Biochemical Journal. 468 (1): 17–24. doi:10.1042/BJ20141506. ISSN   1470-8728. PMID   25940733.
  2. ↑ Todd AE, Orengo CA, Thornton JM (October 2002). "Sequence and structural differences between enzyme and nonenzyme homologs". Structure. 10 (10): 1435–51. doi: 10.1016/s0969-2126(02)00861-4 . PMID   12377129.
  3. ↑ Fischer, Katja; Reynolds, Simone L. (2015-05-15). "Pseudoproteases: mechanisms and function" . Biochemical Journal. 468 (1): 17–24. doi:10.1042/BJ20141506. ISSN   1470-8728. PMID   25940733.


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