Male infertility is often overlooked but, has become more prevalent in the 21st century. As 17.5% of the world have reported experiences with infertility; its one of the main concerning reproductive issues nation wide. [1] Still, studies concerning males are also few in number but have come to the forefront in the past decade starting in 2001. Even so, infertility generally pertains to the inability to conceive within a year time span for both sexes. [2] This can be due to various factors in women and men; for men specifically, it can be related to physical health, fluctuation of hormones, genetic dispositions or ejaculatory dysfunctions. [2] As far as the physical toll, male infertility has shown to cause significant psychological effects too; it has the power to cause low levels of self esteem, emotional distress and feeling of emasculation. [3] [4] [5] According to Dr. Rheta Keylor, of the Massachusetts Institute for Psychoanalysis, suggests that infertility can feel like an "assault on a man's sense of self revives feelings of competition, castration, and experiences of developmental trauma.” [3] Thus, creating a scene of shame for men. Samaira Malik, from the Institute of Work, Health, and Organizations at the University of Nottingham, UK, said, “men are in fact equally affected by the unfulfilled desire for a child but are less open about their feelings.” [6] Therefore, understanding the psychological effects, this has on men, greatly contributes to discovering effective coping strategies to better assist their care.
Feelings of stress, depression, guilt, or anxiety in infertile men can cause psychogenic impotence, which heightens the feelings of inadequacy that already accompany infertility. Hence, stress easily activate the hypothalamus-pituitary- adrenal axis which manages the bodies cortizol levels. [7] Though, when cortisol levels are too high it impacts the production of testosterone which can decreases levels of libido; too much cortisol can cause HPA axis dysfunction as well. [7] Addition, other studies suggest that the psychological stress of infertility demonstrate an effect on sperm parameters in significant and demonstrable ways that may further contribute to difficulties with erectile potency; emotional reactions to the infertility may alter or even undermine a previous consolidation of a sense of self as sexually adequate. [4] Infertility weighs on many males' minds; this creates mental instability, which often results in impotence. Psychological causes of impotency may include:
All of the listed issues above can arise as a result of psychological effects of infertility in men.
The diagnosis of infertility causes many males to question their masculinity; for men are supposed to produce. This perception of masculinity and bearing children can bring feelings of anxiety which is the most common mental health problem associate with infertility. [1] Given that, men may fear permanent infertility, relationship status changes and becoming overly frustrated. Research indicates that "the highest and lowest prevalence of anxiety in these men were 34.9% and 7.08%." [1] This highlight the reason for more research to be conducted. Following, male factor infertility is frequently associated with high levels of social stigma; for example, in a study exploring the views of fertile individuals towards infertile men and women, Miall (1994) [8] found that male infertility was frequently seen as arising from sexual dysfunction and was thus associated with higher levels of stigma than female infertility. [9] Many people assume that infertile men cannot perform sexually. This stigma adds to the heightened insecurities in infertile men. Laura A. Peronace, from the School of Psychology at Cardiff University, said, “Male factor infertility is proposed to have such a social stigma that it produces stress, and a culture of secrecy and protectiveness to the extent that women sometimes even take the blame for the couple's childlessness.” [10] However, infertile men are likely to be depressive and anxious, and have lower masculinity scores and self-esteem. [11] Often, males do not show emotional stress in attempts to be the emotional stability within the relationship. [12] Men cannot suppress such feelings for long periods of time without repercussions.
Feelings about fertility and sexual adequacy are interconnected for many men, [13] especially through male factor infertility. Couples with long term infertility, who have faced much treatment failure, report higher levels of depression, low satisfaction with their sex lives, and low levels of well being.” [14] The stigma of male factor infertility described earlier has huge effects on the man. The problems infertile men have with sexual inadequacy stem from social ridicule and resulting low self-esteem. It is estimated that 40% of infertile individuals experience significant emotional distress with possible long-term implications. [15] M.J. Muller, from the University of Mainz, Germany, said, “Sexual dissatisfaction of infertile men could also be related to a withdrawal from sexual activities and hence to even lower chances of conception.” [16] Infertility can plague an individual all of their life. Subjects are infertile if they have unprotected sex for 12 months resulting in no pregnancy. This means that the diagnosed infertility may be temporary and/or reversible.
The most prevalent psychological treatment is counseling and marriage therapy. A lot of men believe that there are numerous disincentives to psychological treatment despite its potential benefits, especially for those forms of infertility most linked to psychological and behavioral factors. [17] Men are much less likely to seek out psychological help than women. Men who acknowledge infertility, articulate the sources of their anxiety, express their loss of confidence in sexual adequacy, deal openly with their wives' disappointment and anger, and consciously redefine their male and marital roles show improved sperm counts and may even be more successful at impregnating their wives. [18] There is an important role of psychoanalytic treatment when dealing with male infertility.
Anxiety is an emotion characterised by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events. Anxiety is different from fear in that fear is defined as the emotional response to a present threat, whereas anxiety is the anticipation of a future one. It is often accompanied by nervous behavior such as pacing back and forth, somatic complaints, and rumination.
Stress, whether physiological, biological or psychological, is an organism's response to a stressor such as an environmental condition. When stressed by stimuli that alter an organism's environment, multiple systems respond across the body. In humans and most mammals, the autonomic nervous system and hypothalamic-pituitary-adrenal (HPA) axis are the two major systems that respond to stress. Two well-known hormones that humans produce during stressful situations are adrenaline and cortisol.
Infertility is the inability of a couple to reproduce by natural means. It is usually not the natural state of a healthy adult. Exceptions include children who have not undergone puberty, which is the body's start of reproductive capacity. It is also a normal state in women after menopause.
The anterior pituitary is a major organ of the endocrine system. The anterior pituitary is the glandular, anterior lobe that together with the makes up the pituitary gland (hypophysis) which, in humans, is located at the base of the brain, protruding off the bottom of the hypothalamus.
Sexual medicine or psychosexual medicine as defined by Masters and Johnsons in their classic Textbook of Sexual Medicine, is "that branch of medicine that focuses on the evaluation and treatment of sexual disorders, which have a high prevalence rate." Examples of disorders treated with sexual medicine are erectile dysfunction, hypogonadism, and prostate cancer. Sexual medicine often uses a multidisciplinary approach involving physicians, mental health professionals, social workers, and sex therapists. Sexual medicine physicians often approach treatment with medicine and surgery, while sex therapists often focus on behavioral treatments.
Acute stress reaction (ASR), also known as psychological shock, mental shock, or simply shock, as well as acute stress disorder (ASD), is a psychological response to a terrifying, traumatic, or surprising experience. The reactions may include but are not limited to intrusive thoughts, or dissociation, and reactivity symptoms such as avoidance or hyperarousal. It may be exhibited for days or weeks after the traumatic event. If the condition is not correctly addressed, it may develop into post-traumatic stress disorder (PTSD).
The hypothalamic–pituitary–gonadal axis refers to the hypothalamus, pituitary gland, and gonadal glands as if these individual endocrine glands were a single entity. Because these glands often act in concert, physiologists and endocrinologists find it convenient and descriptive to speak of them as a single system.
Sex is correlated with the prevalence of certain mental disorders, including depression, anxiety and somatic complaints. For example, women are more likely to be diagnosed with major depression, while men are more likely to be diagnosed with substance abuse and antisocial personality disorder. There are no marked gender differences in the diagnosis rates of disorders like schizophrenia and bipolar disorder. Men are at risk to suffer from post-traumatic stress disorder (PTSD) due to past violent experiences such as accidents, wars and witnessing death, and women are diagnosed with PTSD at higher rates due to experiences with sexual assault, rape and child sexual abuse. Nonbinary or genderqueer identification describes people who do not identify as either male or female. People who identify as nonbinary or gender queer show increased risk for depression, anxiety and post-traumatic stress disorder. People who identify as transgender demonstrate increased risk for depression, anxiety, and post-traumatic stress disorder.
The Trier social stress test (TSST) is a laboratory procedure used to reliably induce stress in human research participants. It is a combination of procedures that were previously known to induce stress, but previous procedures did not do so reliably. It was created in 1993 at the University of Trier by Clemens Kirschbaum and colleagues.
Psychological dependence is a cognitive disorder and a form of dependence that is characterized by emotional–motivational withdrawal symptoms upon cessation of prolonged drug use or certain repetitive behaviors. Consistent and frequent exposure to particular substances or behaviors is responsible for inducing psychological dependence, requiring ongoing engagement to prevent the onset of an unpleasant withdrawal syndrome driven by negative reinforcement. Neuronal counter-adaptation is believed to contribute to the generation of withdrawal symptoms through changes in neurotransmitter activity or altered receptor expression. Environmental enrichment and physical activity have been shown to attenuate withdrawal symptoms.
Functional hypothalamic amenorrhea (FHA) is a form of amenorrhea and chronic anovulation and is one of the most common types of secondary amenorrhea. It is classified as hypogonadotropic hypogonadism.
The effects of stress on memory include interference with a person's capacity to encode memory and the ability to retrieve information. Stimuli, like stress, improved memory when it was related to learning the subject. During times of stress, the body reacts by secreting stress hormones into the bloodstream. Stress can cause acute and chronic changes in certain brain areas which can cause long-term damage. Over-secretion of stress hormones most frequently impairs long-term delayed recall memory, but can enhance short-term, immediate recall memory. This enhancement is particularly relative in emotional memory. In particular, the hippocampus, prefrontal cortex and the amygdala are affected. One class of stress hormone responsible for negatively affecting long-term, delayed recall memory is the glucocorticoids (GCs), the most notable of which is cortisol. Glucocorticoids facilitate and impair the actions of stress in the brain memory process. Cortisol is a known biomarker for stress. Under normal circumstances, the hippocampus regulates the production of cortisol through negative feedback because it has many receptors that are sensitive to these stress hormones. However, an excess of cortisol can impair the ability of the hippocampus to both encode and recall memories. These stress hormones are also hindering the hippocampus from receiving enough energy by diverting glucose levels to surrounding muscles.
Early childhood is a critical period in a child's life that includes ages from birth to five years old. Psychological stress is an inevitable part of life. Human beings can experience stress from an early age. Although stress is a factor for the average human being, it can be a positive or negative molding aspect in a young child's life.
Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. As compensation and the lack of negative feedback, gonadotropin levels are elevated. Individuals with HH have an intact and functioning hypothalamus and pituitary glands so they are still able to produce FSH and LH. HH may present as either congenital or acquired, but the majority of cases are of the former nature. HH can be treated with hormone replacement therapy.
Early childhood trauma refers to various types of adversity and traumatic events experienced during the early years of a person's life. This is deemed the most critical developmental period in human life by psychologists. A critical period refers to a sensitive time during the early years of childhood in which children may be more vulnerable to be affected by environmental stimulation. These traumatic events can include serious illness, natural disasters, family violence, sudden separation from a family member, being the victim of abuse, or suffering the loss of a loved one. Traumatic experiences in early childhood can result in severe consequences throughout adulthood, for instance developing post-traumatic stress disorder, depression, or anxiety. The effects of this trauma can be experienced very differently depending on factors such as how long the trauma was, how severe and even the age of the child when it occurred. Negative childhood experiences can have a tremendous impact on future violence victimization and perpetration, and lifelong health and opportunity. However, not all children who are exposed to negative stimuli in early childhood will be affected severely in later life; some children come out unscathed after being faced with traumatic events, which is known as resilience. Many factors can account for the invulnerability displayed by certain children in response to adverse social conditions: gender, vulnerability, social support systems, and innate character traits. Much of the research in this area has referred to the Adverse Childhood Experiences Study (ACE) study. The ACE study found several protective factors against developing mental health disorders, including mother-child relations, parental health, and community support. However, having adverse childhood experiences creates long-lasting impacts on psychosocial functioning, such as a heightened awareness of environmental threats, feelings of loneliness, and cognitive deficits. Individuals with ACEs are more prone to developing severe symptoms than individuals in the same diagnostic category.
Maternal fetal stress transfer is a physiological phenomenon in which psychosocial stress experienced by a mother during her pregnancy can be transferred to the fetus. Psychosocial stress describes the brain's physiological response to perceived social threat. Because of a link in blood supply between a mother and fetus, it has been found that stress can leave lasting effects on a developing fetus, even before a child is born. According to recent studies, these effects are mainly the result of two particular stress biomarkers circulating in the maternal blood supply: cortisol and catecholamines.
Epigenetics of anxiety and stress–related disorders is the field studying the relationship between epigenetic modifications of genes and anxiety and stress-related disorders, including mental health disorders such as generalized anxiety disorder (GAD), post-traumatic stress disorder, obsessive-compulsive disorder (OCD), and more. These changes can lead to transgenerational stress inheritance.
Opioid-induced endocrinopathy (OIE) is a complication of chronic opioid treatment. It is a common name for all hypothalamo-pituitary axis disorders, which can be observed mostly after long term use of opioids, both as a treatment and as a substance of abuse.
In social psychology, social buffering is a phenomenon where social connections can alleviate negative consequences of stressful events.
Mental stress-induced myocardial ischemia (MSIMI) is a medical condition in which acute psychological stress can trigger a transient myocardial ischemia, which is a state of reduced blood flow to the heart muscle, often without the presence of significant coronary artery disease (CAD). It is distinct from conventional stress ischemia caused by physical exertion or pharmacological agents. MSIMI is often silent and detected through specific cardiac function tests during mental stress challenges.