Puerto Rico Highway 18 (PR-18) is a freeway in Puerto Rico, which is also known as Expreso Las Américas. It runs from its north end at its intersection with PR-22 in San Juan to its south end in Río Piedras where it intersects with PR-1. At this point PR-18 becomes PR-52, known as Autopista Luis A. Ferré.
Puerto Rico Highway 413 (PR-413) is a rural road located at the west point of Rincón, Puerto Rico and is famous in the island for being the main access to beaches near Tres Palmas and the Rincón Lighthouse, where local and international surfing tournaments take place. It is named the "Road to Happiness".
Puerto Rico Highway 65 (PR-65) is a short highway connecting Puerto Rico Highway PR-239, also locally known as Alfonso Valdés Cobián Boulevard near University of Puerto Rico at Mayagüez, to Puerto Rico Highway 106. It has not an intersection to the main highway PR-2, but can be accessed quickly going west of the alt route. It is also the main highway to the Palacio de Recreación y Deportes and to the Parque de los Próceres.
Puerto Rico Highway 8 (PR-8) is a main highway that serves as a third route from San Juan, Puerto Rico to Carolina, Puerto Rico. It is, still, a highly congested highway, noticeable when congestion jams are found in PR-17 where PR-8 begins and it continues to PR-3. The first kilometers of PR-8 were known before as Puerto Rico Highway 4, but the Department of Transportation renumbered the entire highway PR-8 and there is no longer a PR-4. It ends in PR-3 in Carolina.
Puerto Rico Highway 301 (PR-301) is a main highway in Cabo Rojo, Puerto Rico. It begins in PR-101, close to PR-100, and goes south all the way to Los Morrillos Light, where it ends. It is the main access to the lighthouse, the Cabo Rojo cliffs, and Playa Sucia.
Puerto Rico Highway 344 (PR-344) is a rural road in Hormigueros, Puerto Rico, beginning from near the municipality's small downtown and ending at PR-348 near the border with San Germán in barrio Rosario. It has narrow lanes, and after about five kilometers becomes one of the most dangerous highways in Puerto Rico, as it goes near a precipice with little or no safety barriers. It serves as a route to Mayagüez via PR-348 which ends in Puerto Rico Alt Route 2.
Avenida Juan Ponce de León, coextensive as Route PR-25 along its entire length, is one of the main thoroughfares in San Juan, Puerto Rico.
Puerto Rico Highway 47 (PR-47), also known as Calle De Diego, is an urban road in Río Piedras, Puerto Rico.
Puerto Rico Highway 42 (PR-42) is an urban road in Santurce. This is a short road that connects from the PR-39 to Lafayette Street and intersects with PR-2. It is parallel to the PR-35 and PR-25. This road is called Calle Las Palmas.
Puerto Rico Highway 40 (PR-40) is an urban road in Hato Rey. This is a short road that connects from the PR-25 to PR-27. This road is called Avenida Quisqueya.
Puerto Rico Highway 39 (PR-39) is an urban road in Santurce. This is a short road that connects from the PR-1 to PR-26 and is parallel to PR-2. This road intersects with PR-35 and PR-25. This road is called Calle Cerra.
Puerto Rico Highway 16 (PR-16) is an urban road in Santurce, Puerto Rico.
Puerto Rico Highway 34 (PR-34) is an urban road located in Caguas, Puerto Rico. This road extends from Avenida José Garrido (PR-196) in Cañabón barrio to PR-183 in Tomás de Castro barrio, and is part of Turabo and Degetau avenues.
Puerto Rico Highway 238 (PR-238) is an east–west bypass located southeast of downtown Coamo, Puerto Rico. This road extends from PR-153 to PR-14 and is known as Desvío Sur.
Puerto Rico Highway 253 (PR-253) is a tertiary route located in Culebra, Puerto Rico. It goes from the PR-250 on the drawbridge over the Ensenada Canal and runs east, Playa Sardinas II, towards Fulladosa and Punta Aloe. It extends approximately 3.2 km to the access road to Punta del Soldado.
Puerto Rico Highway 251 (PR-251) is a road located in Culebra, Puerto Rico.
Puerto Rico Highway 250 (PR-250) is the main and longest highway located in Culebra, Puerto Rico.
Puerto Rico Highway 693 (PR-693) is a road located between the municipalities of Dorado, Puerto Rico and Vega Alta, passing through downtown Dorado. It begins at its intersection with PR-2 and PR-165 in Río Lajas and ends at PR-690 in Sabana. It is a short divided highway in southern Dorado, which serves as an alternate route for PR-165 west of Río de la Plata.
Puerto Rico Highway 200 (PR-200) is a road located in Vieques, Puerto Rico. This highway extends from Mosquito to Puerto Diablo, passing through Isabel II.
Puerto Rico Highway 633 (PR-633) is an east–west rural road located between the municipalities of Ciales and Morovis, Puerto Rico. It begins at its intersection with PR-149 in Hato Viejo barrio and ends at its junction with PR-155 in Barahona.
PR-250 in Playa Sardinas I–Culebra barrio-pueblo 
