Pumiliotoxin

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Pumiliotoxin A: R = -H
Pumiliotoxin B: R = -OH Pumiliotoxin AB.svg
Pumiliotoxin A: R = –H
Pumiliotoxin B: R = –OH
Pumiliotoxin 251D Pumiliotoxin251D.png
Pumiliotoxin 251D

Pumiliotoxins (PTXs), are one of several toxins found in the skin of poison dart frogs. The frog species, P. bibronii also produces PTXs to deter predators. Closely related, though more toxic, are allopumiliotoxins, (aPTXs). Other toxins found in the skin of poison frogs include decahydroquinolines (DHQs), izidines, coccinellines, and spiropyrrolizidine alkaloids. Pumiliotoxins are very poisonous in high concentrations. Pumiliotoxins are much weaker than batrachotoxins, ranging between 100 and 1000 times less poisonous. There are three different types of this toxin: A, B and C, of which toxins A and B are more toxic than C. Pumiliotoxins interfere with muscle contraction by affecting calcium channels, causing partial paralysis, difficulty moving, hyperactivity, [1] or death. The median lethal dose of pumiliotoxins A and B is 50 μg / mouse, 20 μg / mouse respectively, while the amount of pumiliotoxin is 200 μg / frog. [2]

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<span class="mw-page-title-main">Poison dart frog</span> Family of amphibians

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<span class="mw-page-title-main">Batrachotoxin</span> Chemical compound

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<span class="mw-page-title-main">Epibatidine</span> Toxic chemical from some poison dart frogs

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PTX may refer to:

<i>Phyllobates</i> Genus of amphibians

Phyllobates is a genus of poison dart frogs native to Central and South America, from Nicaragua to Colombia. There are 3 different Colombian species of Phyllobates, considered highly toxic species due to the poison they contain in the wild.

<i>Phyllobates aurotaenia</i> Species of amphibian

Phyllobates aurotaenia is a member of the frog family Dendrobatidae, which are found in the tropical environments of Central and South America. First described by zoologist George Albert Boulenger in 1913, P. aurotaenia is known for being the third most poisonous frog in the world. It is the smallest of the poison dart frogs in the Phyllobates genus and is endemic to the Pacific coast of Colombia.

<span class="mw-page-title-main">Lehmann's poison frog</span> Species of amphibian

Lehmann's poison frog or the red-banded poison frog is a species of frogs in the family Dendrobatidae endemic to a small part of western Colombia. Its natural habitats are submontane tropical rainforests. It is threatened by habitat loss and collection for the pet trade, and the IUCN lists it as being "critically endangered". It was named after Colombian conservation biologist Federico Carlos Lehmann.

<i>Oophaga sylvatica</i> Species of amphibian

Oophaga sylvatica, sometimes known as its Spanish name diablito, is a species of frog in the family Dendrobatidae found in Southwestern Colombia and Northwestern Ecuador. Its natural habitat is lowland and submontane rainforest; it can, however, survive in moderately degraded areas, at least in the more humid parts of its range. It is a very common frog in Colombia, but has disappeared from much of its Ecuadorian range. It is threatened by habitat loss (deforestation) and agricultural pollution and sometimes seen in the international pet trade.

<span class="mw-page-title-main">Pumiliotoxin 251D</span> Chemical compound

Pumiliotoxin 251D is a toxic organic compound. It is found in the skin of poison frogs from the genera Dendrobates, Epipedobates, Minyobates, and Phyllobates and toads from the genus Melanophryniscus. Its name comes from the pumiliotoxin family (PTXs) and its molecular mass of 251 daltons. When the toxin enters the bloodstream through cuts in the skin or by ingestion, it can cause hyperactivity, convulsions, cardiac arrest and ultimately death. It is especially toxic to arthropods, even at low concentrations.

<span class="mw-page-title-main">Allopumiliotoxin 267A</span> Chemical compound

Allopumiliotoxin 267A is a toxin found in the skin of several poison frogs of the family Dendrobates. It is a member of the class of compounds known as allopumiliotoxins. The frogs produce the toxin by modifying the original version, pumiliotoxin 251D. It has been tested on mice and found to be five times more potent than the former version. It has been produced synthetically through a variety of different routes.

<span class="mw-page-title-main">Allopumiliotoxin</span> Group of chemical compounds

Allopumiliotoxins are a structural division in the pumiliotoxin-A class of alkaloids. The compounds of the pumiliotoxin-A class are primarily found in the skins of frogs, toads, and other amphibians and are used as a chemical defense mechanism to ward off predators, microorganisms, and ectoparasites. The compounds were originally discovered in neotropical dendrobatid frogs, but are also found in the mantellid frogs of Madagascar, myobatrachid frogs of Australia, and bufonid toad of South America. Frogs possessing this defense mechanism have aposematic coloring.

<i>Adelphobates</i> Genus of amphibians

Adelphobates is a small genus of poison dart frogs. They are found in the central and lower Amazon basin of Peru and Brazil, possibly Bolivia. It was originally erected as a sister group to the Dendrobates and Oophaga genera. The validity of the genus is still being discussed, with the alternative being "Dendrobates galactonotus group" within Dendrobates. One species originally placed in this genus as Adelphobates captivus has since been moved to the genus Excidobates erected in 2008.

<span class="mw-page-title-main">Poisonous amphibian</span> Amphibians that produce poison

Poisonous amphibians are amphibians that produce toxins to defend themselves from predators.

<i>Phyllobates</i> sp. aff. <i>aurotaenia</i> Species of amphibian

Phyllobates sp. aff. aurotaenia is a temporary name given to a likely new species of poison dart frog, formerly known as the "red" form of Phyllobates aurotaenia. It is morphologically similar to P. aurotaenia, but genetically it is more closely related to P. terribilis. It can be distinguished from P. aurotaenia by its uniform black or bluish-black body, and its orange or red, rather than green or yellow, stripes.

<span class="mw-page-title-main">Sira poison dart frog</span> Species of amphibian

Ranitomeya sirensis or the Sira poison frog is a species of poison dart frog found in the Amazonian rainforests of northern Bolivia, westernmost Brazil (Acre), and eastern Peru.

References

  1. Daly, JW; Garraffo, HM; Spande, TF; et al. (September 2003). "Evidence for an enantioselective pumiliotoxin 7-hydroxylase in dendrobatid poison frogs of the genus Dendrobates". Proc. Natl. Acad. Sci. U.S.A. 100 (19): 11092–7. Bibcode:2003PNAS..10011092D. doi: 10.1073/pnas.1834430100 . PMC   196932 . PMID   12960405.
  2. Riley, Darren Lyall (October 2007). Synthesis of amphibian indolizidine alkaloids and related compounds from enaminone precursors (PDF) (Doctor of Philosophy thesis). University of the Witwatersrand. p. 8. Retrieved 2024-08-15.