Quality of Life Index for Atopic Dermatitis

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The Quality of Life Index for Atopic Dermatitis (QoLIAD) is a disease specific patient reported outcome which measures the impact that atopic dermatitis (AD) has on a given patient's quality of life. [1]

Contents

It is a 25-item questionnaire for patients over the age of 16 [2] with a maximum score of 25 and is restricted to yes or no answers. [3] Higher scores on the QoLIAD indicate a greater negative influence that the disease has on quality of life. [4]

Development

The QoLIAD was developed in 2004 and funded by Novartis Pharma AG, Switzerland. It was produced in several countries and the content was derived from 65 qualitative interviews with patients in the UK, Italy and Netherlands. The initial version of the measure was produced in UK English and it was then translated for the Netherlands, Italy, Germany, France and the US. A Spanish version was then later developed. Further tests were implemented to validate the measure and it was administered to 300 patients in each country to finalize the instrument. [5]

The institutions involved in the development of the QoLIAD are: Galen Research (United Kingdom), Erasmus University (The Netherlands), University of Greifswald (Germany), University of Verona (Italy), C.H.U Bichat (France), 3D Health Research (Spain) and Novartis Pharmaceuticals Corporation (USA). [5]

International use

The QoLIAD has been translated into seven languages other than UK English. [6] They include German, Spanish and Japanese.

The QoLIAD has also been utilized to assess the effectiveness of new treatments of atopic dermatitis. This includes studies looking into educational intervention, [4] [7] topical corticosteroids [8] and pimecrolimus. [9]

Related Research Articles

<span class="mw-page-title-main">Dermatitis</span> Inflammatory disease of the skin

Dermatitis is inflammation of the skin, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened. The area of skin involved can vary from small to covering the entire body. Dermatitis is often called eczema, and the difference between those terms is not standardized.

<span class="mw-page-title-main">Corticosteroid</span> Class of steroid hormones

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.

<span class="mw-page-title-main">Tacrolimus</span> Immunosuppressive drug

Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogenic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. For example, it is prescribed for severe refractory uveitis after a bone marrow transplant, exacerbations of minimal change disease, Kimura's disease, and vitiligo. It can be used to treat dry eye syndrome in cats and dogs.

<span class="mw-page-title-main">Irritant diaper dermatitis</span> Medical condition

Irritant diaper dermatitis is a generic term applied to skin rash in the diaper area that are caused by various skin disorders and/or irritants.

<span class="mw-page-title-main">Seborrhoeic dermatitis</span> Skin disease

Seborrhoeic dermatitis is a long-term skin disorder. Symptoms include flaky, scaly, greasy, and occasionally itchy and inflamed skin. Areas of the skin rich in oil-producing glands are often affected including the scalp, face, and chest. It can result in social or self-esteem problems. In babies, when the scalp is primarily involved, it is called cradle cap. Seborrhoeic dermatitis of the scalp may be described in lay terms as dandruff due to the dry, flaky character of the skin. However, as dandruff may refer to any dryness or scaling of the scalp, not all dandruff is seborrhoeic dermatitis. Seborrhoeic dermatitis is sometimes inaccurately referred to as seborrhoea.

<span class="mw-page-title-main">Pimecrolimus</span> Immunosuppressive drug

Pimecrolimus is an immunosuppressant drug of the calcineurin inhibitor class used in the treatment of atopic dermatitis (eczema).

Antipruritics, abirritants, or anti-itch drugs, are medications that inhibit the itching often associated with sunburns, allergic reactions, eczema, psoriasis, chickenpox, fungal infections, insect bites and stings like those from mosquitoes, fleas, and mites, and contact dermatitis and urticaria caused by plants such as poison ivy or stinging nettle. It can also be caused by chronic kidney disease and related conditions.

<span class="mw-page-title-main">Nummular dermatitis</span> Medical condition

Nummular dermatitis is one of the many forms of dermatitis. It is characterized by round or oval-shaped itchy lesions. The name comes from the Latin word "nummus," which means "coin."

<span class="mw-page-title-main">Dyshidrosis</span> Inflammatory disease of the skin in humans

Dyshidrosis is a type of dermatitis, characterized by itchy vesicles of 1–2 mm in size, on the palms of the hands, sides of fingers, or bottoms of the feet. Outbreaks usually conclude within three to four weeks, but often recur. Repeated attacks may result in fissures and skin thickening. The cause of the condition is not known.

<span class="mw-page-title-main">Desonide</span> Chemical compound

Desonide (INN) is a low-potency topical corticosteroid anti-inflammatory that has been available since the 1970s. It is primarily used to treat atopic dermatitis (eczema), seborrheic dermatitis, contact dermatitis and psoriasis in both adults and children. It has a fairly good safety profile and is available as a cream, ointment, lotion, and as a foam under the tradename Verdeso Foam. Other trade names for creams, lotions, and ointments include Tridesilon, DesOwen, Desonate. It is a group VI corticosteroid under US classification, the second least potent group.

<span class="mw-page-title-main">Atopic dermatitis</span> Long-term form of skin inflammation

Atopic dermatitis (AD), also known as atopic eczema, is a long-term type of inflammation of the skin (dermatitis). It results in itchy, red, swollen, and cracked skin. Clear fluid may come from the affected areas, which can thicken over time. AD may also simply be called eczema, a term that generally refers to a larger group of skin conditions.

The SCORAD index is a clinical tool for assessing the extent of the disease, disease intensity, and subjective symptoms of atopic dermatitis. It gives approximate weights of 60% to intensity and 20% each to extent and subjective symptoms. These are used to calculate a maximum total score of 103, however, the scores for each category can be used individually if clinically appropriate.

<span class="mw-page-title-main">Mometasone</span> Steroid medication

Mometasone, also known as mometasone y 3 s, is a steroid medication used to treat certain skin conditions, hay fever, and asthma. Specifically it is used to prevent rather than treat asthma attacks. It can be applied to the skin, inhaled, or used in the nose. Mometasone furoate, not mometasone, is used in medical products.

In medicine, a finger tip unit (FTU) is defined as the amount of ointment, cream or other semi-solid dosage form expressed from a tube with a 5 mm diameter nozzle, applied from the distal skin-crease to the tip of the index finger of an adult. The "distal skin-crease" is the skin crease over the joint nearest the end of the finger. One FTU is enough to treat an area of skin twice the size of the flat of an adult's hand with the fingers together, i.e. a "handprint". Two FTUs are approximately equivalent to 1 g of topical steroid.

Topical steroids are the topical forms of corticosteroids. Topical steroids are the most commonly prescribed topical medications for the treatment of rash and eczema. Topical steroids have anti-inflammatory properties and are classified based on their skin vasoconstrictive abilities. There are numerous topical steroid products. All the preparations in each class have the same anti-inflammatory properties but essentially differ in base and price.

<span class="mw-page-title-main">Hand eczema</span> Skin condition

Hand eczema presents on the palms and soles, and may sometimes be difficult or impossible to differentiate from atopic dermatitis, allergic contact dermatitis, and psoriasis, which also commonly involve the hands. Even a biopsy of all these conditions may not result in a definitive diagnosis, as all three conditions may demonstrate spongiosis and crusting on the hands.

<span class="mw-page-title-main">Topical steroid withdrawal</span> Medical condition

Topical steroid withdrawal, also known as red burning skin and steroid dermatitis, has been reported in people who apply topical steroids for 2 weeks or longer and then discontinue use. Symptoms affect the skin and include redness, a burning sensation, and itchiness, which may then be followed by peeling.

Sodium hypochlorite washes are skin cleansers formulated with sodium hypochlorite (NaOCl) and surfactants. These cleansing liquids or gels are lathered onto wet skin and rinsed off. They are recommended for inflammatory skin conditions, microbial driven skin disorders and body odor.

<span class="mw-page-title-main">Topical glucocorticoids</span>

Topical glucocorticoids are the topical forms of glucocorticoids. Topical glucocorticoids are used in the treatment of many skin conditions. They provide anti-inflammatory, antimitotic, and immune-system suppressing actions through various mechanisms.

References

  1. ↑ Meads, D.M.; McKenna, S.P.; Doward, L.C.; Hampson, N.; McGeown, C. (May 2005). "Psk6 Interpreting Scores on the Quality of Life Index for Atopic Dermatitis (Qoliad)". Value in Health. 8 (3): 331–332. doi: 10.1016/S1098-3015(10)62870-7 . Retrieved 28 October 2013.
  2. ↑ Ehlken, B.; Kugland, B; Schramm, B; Quednau, K; Berger, K. (November 2003). "Psn12 Quality-Of-Life in Patients Suffering from Atopic Dermatitis in Germany". Value in Health. 6 (6): 787–788. doi: 10.1016/S1098-3015(10)62005-0 . Retrieved 28 October 2013.
  3. ↑ Ashcroft, D.M.; Chen, L.C.; Garside, R.; Stein, K.; Williams, H.C. (2007). Ashcroft, Darren M (ed.). "Topical pimecrolimus for eczema (Review)". Cochrane Database of Systematic Reviews (4): CD005500. doi:10.1002/14651858.CD005500.pub2. PMC   10043871 . PMID   17943859.
  4. 1 2 Lambert, J.; Bostoen, J.; Geusens, B.; Bourgois, J.; Boone, J.; De Smedt, D.; Annemans, L. (January 2011). "A novel multidisciplinary educational programme for patients with chronic skin diseases: Ghent pilot project and first results". Archives of Dermatological Research. 303 (1): 57–63. doi:10.1007/s00403-010-1082-z. PMID   20842368. S2CID   20817434.
  5. 1 2 Whalley, D.; McKenna, S.P.; Dewar, A.L.; Erdman, R.A.; Kohlmann, T.; Niero, M.; Cook, S.A.; Crickx, B.; Herdman, M.J.; Frech, F.; Van Assche, D. (2004). "A new instrument for assessing quality of life in atopic dermatitis: international development of the Quality of Life Index for Atopic Dermatitis (QoLIAD)". British Journal of Dermatology. 150 (2): 274–283. doi:10.1111/j.1365-2133.2004.05783.x. PMID   14996098. S2CID   23271179.
  6. ↑ "Measures Database". Galen-Research.com. Galen Research. Retrieved 28 October 2013.
  7. ↑ Bostoen, J.; Bracke, S.; De Keyser, S.; Lambert, J. (November 2012). "An educational programme for patients with psoriasis and atopic dermatitis: a prospective randomized controlled trial". The British Journal of Dermatology. 167 (5): 1025–1031. doi:10.1111/j.1365-2133.2012.11113.x. PMID   22709422. S2CID   11139439.
  8. ↑ Lax, Stephanie J; Harvey, Jane; Axon, Emma; Howells, Laura; Santer, Miriam; et al. (March 2022). "Strategies for using topical corticosteroids in children and adults with eczema". The Cochrane Database of Systematic Reviews. 2022 (3): CD013356. doi:10.1002/14651858.CD013356.pub2. ISSN   1469-493X. PMC   8916090 . PMID   35275399.
  9. ↑ Lecomte, P.; Lambert, J.; Degreef, H.; Lesaffre, E.; De Backer, M. (November 2006). "PSK6 BELGIAN DRUG UTILISATION STUDY OF ELIDEL® IN ROUTINE PRACTICE IN ATOPIC DERMATITIS". Value in Health. 9 (6): A268. doi: 10.1016/S1098-3015(10)63408-0 . Retrieved 28 October 2013.
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