RAB7L1

Last updated

RAB7, member RAS oncogene family-like 1 is a protein that in humans is encoded by the RAB7L1 gene. [1] The gene is also known as RAB7L. RAB7L1 encodes a small GTP-binding protein and is a member of the Ras superfamily. [1] [2]

Contents

Model organisms

Model organisms have been used in the study of RAB7L1 function. A conditional knockout mouse line, called Rab7l1tm1a(EUCOMM)Wtsi [6] [7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute. [8] [9] [10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. [4] [11] Twenty one tests were carried out on mutant mice, but no significant abnormalities were observed. [4]

Related Research Articles

<span class="mw-page-title-main">TRPC4AP</span> Protein-coding gene in the species Homo sapiens

Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.

<span class="mw-page-title-main">ARID4A</span> Protein-coding gene in humans

AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene.

<span class="mw-page-title-main">ARL4D</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene.

<span class="mw-page-title-main">NPLOC4</span> Protein-coding gene in humans

Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene.

<span class="mw-page-title-main">COQ9</span> Protein-coding gene in humans

Ubiquinone biosynthesis protein COQ9, mitochondrial, also known as coenzyme Q9 homolog (COQ9), is a protein that in humans is encoded by the COQ9 gene.

<span class="mw-page-title-main">PRPSAP2</span> Protein-coding gene in the species Homo sapiens

Phosphoribosyl pyrophosphate synthetase-associated protein 2 is a protein that in humans is encoded by the PRPSAP2 gene.

<span class="mw-page-title-main">FUNDC1</span> Protein-coding gene in humans

FUN14 domain containing 1 is a protein that in humans is encoded by the FUNDC1 gene.

<span class="mw-page-title-main">DCTN5</span> Protein-coding gene in the species Homo sapiens

Dynactin 5 (p25) is a protein that in humans is encoded by the DCTN5 gene.

<span class="mw-page-title-main">MDN1</span> Protein-coding gene in the species Homo sapiens

MDN1, midasin homolog (yeast) is a protein that in humans is encoded by the MDN1 gene. Midasin is a member AAA ATPase family.

<span class="mw-page-title-main">MTRF1L</span> Protein-coding gene in the species Homo sapiens

Mitochondrial translational release factor 1-like is a protein that in humans is encoded by the MTRF1L gene.

<span class="mw-page-title-main">CCDC137</span> Protein found in humans

Coiled-coil domain containing 137 is a protein that in humans is encoded by the CCDC137 gene.

<span class="mw-page-title-main">TTLL3</span> Protein-coding gene in the species Homo sapiens

Tubulin tyrosine ligase-like family, member 3 is a protein that in humans is encoded by the TTLL3 gene.

Protein arginine methyltransferase 8 is a protein that in humans is encoded by the PRMT8 gene. Arginine methylation is a posttranslational modification involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction and protein compartmentalization. PRMT8 binds and dimethylates Ewing sarcoma breakpoint region 1 (EWS) protein.

<span class="mw-page-title-main">ARHGAP25</span> Protein-coding gene in the species Homo sapiens

Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene. The gene is also known as KAIA0053. ARHGAP25 belongs to a family of Rho GTPase-modulating proteins that are implicated in actin remodeling, cell polarity, and cell migration.

Ankyrin repeat and sterile alpha motif domain containing 4B is a protein that in humans is encoded by the ANKS4B gene. The gene is also known as HARP. Ankyrin repeats mediate protein-protein interactions in very diverse families of proteins.

Asteroid homolog 1 (Drosophila) is a protein that in humans is encoded by the ASTE1 gene. The gene is also known as HT001.

Glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial) is a protein that in humans is encoded by the GATC gene. The gene is also known as 15E1.2 and encodes part of a Glu-tRNA(Gln) amidotransferase enzyme.

Family with sequence similarity 104, member A is a protein that in humans is encoded by the FAM104A gene. The orthologous gene in mice is also known as D11Wsu99e.

<span class="mw-page-title-main">C2orf54</span> Protein-coding gene in the species Homo sapiens

Chromosome 2 open reading frame 54, otherwise known as Mab21L4, is a protein that in humans is encoded by the C2orf54 gene. The orthologue in mice is 2310007B03Rik.

2'-5' oligoadenylate synthetase-like 2 is a protein that in the house mouse is encoded by the Oasl2 gene. The gene is also known as Oasl, M1204 and Mmu-OASL. Oasl2 is a paralogue of Oasl1.

References

  1. 1 2 "RAB7, member RAS oncogene family-like 1" . Retrieved 2011-12-06.
  2. Shimizu, F.; Katagiri, T.; Suzuki, M.; Watanabe, T. K.; Okuno, S.; Kuga, Y.; Nagata, M.; Fujiwara, T.; Nakamura, Y.; Takahashi, E. (1997). "Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily". Cytogenetics and Cell Genetics. 77 (3–4): 261–263. doi:10.1159/000134591. PMID   9284931.
  3. "Citrobacter infection data for Rab7l1". Wellcome Trust Sanger Institute.
  4. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID   85911512.
  5. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. "International Knockout Mouse Consortium".
  7. "Mouse Genome Informatics".
  8. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC   3572410 . PMID   21677750.
  9. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a . PMID   21677718.
  10. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018 . PMID   17218247. S2CID   18872015.
  11. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi: 10.1186/gb-2011-12-6-224 . PMC   3218837 . PMID   21722353.

Further reading