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Randal A. Koene | |
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![]() Randal Koene in October 2014 | |
Alma mater | McGill University, Delft University of Technology |
Known for | Whole brain emulation, Mind uploading |
Scientific career | |
Fields | Neuroscience, Neuroengineering |
Institutions | Tecnalia |
Randal A. Koene is a Dutch neuroscientist and neuroengineer. He co-founded carboncopies.org, an organization dedicated to researching Substrate-Independent Minds (SIM). [1] [2] From 2008 to 2010, Koene served as the Director of the Department of Neuroengineering at the Fatronik-Tecnalia Institute in Spain. [3] He holds a Ph.D. in Computational Neuroscience from McGill University and an M.Sc. in Electrical Engineering with a specialization in Information Theory from Delft University of Technology.
Koene's academic career includes a tenure as a professor at Boston University Center for Memory and Brain and co-founding the Neural Engineering Corporation of Massachusetts. He also established MindUploading.org. [4] He first proposed the term and specific approach called whole brain emulation, aimed at achieving mind transfer to a different substrate.
In his professional research, Koene focuses on implementing whole brain emulation, which involves creating large-scale, high-resolution representations and emulations of neuronal circuitry activity. This work is essential for developing patient-specific neuroprostheses. Additionally, he contributed to the Oxford working group convened in 2007, which aimed at formulating the initial roadmap towards whole brain emulation. [5]
Koene has professional expertise in computational neuroscience, psychology, information theory, electrical engineering and physics. He organizes neural engineering efforts to obtain and replicate functional and structural information from the neural substrate for use in neuroprostheses and neural interfaces. Using NETMORPH, [6] his computational framework for simulating the morphological development of neuronal circuitry, Koene's lab is developing a Virtual Brain Laboratory. This laboratory aims to provide neuroscientists, neuroengineers, and clinicians with large-scale, high-resolution quantitative tools analogous to the computational tools essential in fields such as genetics, chemistry, and aerospace industry.
Neuroscience is the scientific study of the nervous system, its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the biological sciences.
Neural Darwinism is a biological, and more specifically Darwinian and selectionist, approach to understanding global brain function, originally proposed by American biologist, researcher and Nobel-Prize recipient Gerald Maurice Edelman. Edelman's 1987 book Neural Darwinism introduced the public to the theory of neuronal group selection (TNGS), a theory that attempts to explain global brain function.
Cognitive neuroscience is the scientific field that is concerned with the study of the biological processes and aspects that underlie cognition, with a specific focus on the neural connections in the brain which are involved in mental processes. It addresses the questions of how cognitive activities are affected or controlled by neural circuits in the brain. Cognitive neuroscience is a branch of both neuroscience and psychology, overlapping with disciplines such as behavioral neuroscience, cognitive psychology, physiological psychology and affective neuroscience. Cognitive neuroscience relies upon theories in cognitive science coupled with evidence from neurobiology, and computational modeling.
Mind uploading is a speculative process of whole brain emulation in which a brain scan is used to completely emulate the mental state of the individual in a digital computer. The computer would then run a simulation of the brain's information processing, such that it would respond in essentially the same way as the original brain and experience having a sentient conscious mind.
The following outline is provided as an overview of and topical guide to neuroscience:
Behavioral neuroscience, also known as biological psychology, biopsychology, or psychobiology, is the application of the principles of biology to the study of physiological, genetic, and developmental mechanisms of behavior in humans and other animals.
Christof Koch is a German-American neurophysiologist and computational neuroscientist best known for his work on the neural basis of consciousness. He was the president and chief scientist of the Allen Institute for Brain Science in Seattle. He remains at the Institute as a Meritorious Investigator. He is also the Chief Scientist of the Tiny Blue Dot Foundation in Santa Monica, that funds research meant to alleviate suffering, anxiety and other forms of distress in all people.
Terrence Joseph Sejnowski is the Francis Crick Professor at the Salk Institute for Biological Studies where he directs the Computational Neurobiology Laboratory and is the director of the Crick-Jacobs center for theoretical and computational biology. He has performed pioneering research in neural networks and computational neuroscience.
A neural network, also called a neuronal network, is an interconnected population of neurons. Biological neural networks are studied to understand the organization and functioning of nervous systems.
An artificial brain is software and hardware with cognitive abilities similar to those of the animal or human brain.
Neural engineering is a discipline within biomedical engineering that uses engineering techniques to understand, repair, replace, or enhance neural systems. Neural engineers are uniquely qualified to solve design problems at the interface of living neural tissue and non-living constructs.
Stephen Grossberg is a cognitive scientist, theoretical and computational psychologist, neuroscientist, mathematician, biomedical engineer, and neuromorphic technologist. He is the Wang Professor of Cognitive and Neural Systems and a Professor Emeritus of Mathematics & Statistics, Psychological & Brain Sciences, and Biomedical Engineering at Boston University.
Neuroinformatics is the emergent field that combines informatics and neuroscience. Neuroinformatics is related with neuroscience data and information processing by artificial neural networks. There are three main directions where neuroinformatics has to be applied:
Connectomics is the production and study of connectomes: comprehensive maps of connections within an organism's nervous system. More generally, it can be thought of as the study of neuronal wiring diagrams with a focus on how structural connectivity, individual synapses, cellular morphology, and cellular ultrastructure contribute to the make up of a network. The nervous system is a network made of billions of connections and these connections are responsible for our thoughts, emotions, actions, memories, function and dysfunction. Therefore, the study of connectomics aims to advance our understanding of mental health and cognition by understanding how cells in the nervous system are connected and communicate. Because these structures are extremely complex, methods within this field use a high-throughput application of functional and structural neural imaging, most commonly magnetic resonance imaging (MRI), electron microscopy, and histological techniques in order to increase the speed, efficiency, and resolution of these nervous system maps. To date, tens of large scale datasets have been collected spanning the nervous system including the various areas of cortex, cerebellum, the retina, the peripheral nervous system and neuromuscular junctions.
In the field of computational neuroscience, Brain simulation is the concept of creating a functioning computer model of a brain or part of a brain. Brain simulation projects intend to contribute to a complete understanding of the brain, and eventually also assist the process of treating and diagnosing brain diseases. Simulations utilize mathematical models of biological neurons, such as the hodgkin-huxley model, to simulate the behavior of neurons, or other cells within the brain.
The following outline is provided as an overview of and topical guide to brain mapping:
Hypothetical technology is technology that does not exist yet, but that could exist in the future. This article presents examples of technologies that have been hypothesized or proposed, but that have not been developed yet. An example of hypothetical technology is teleportation.
Krishna Vaughn Shenoy (1968–2023) was an American neuroscientist and neuroengineer at Stanford University. Shenoy was the Hong Seh and Vivian W. M. Lim Professor in the Stanford University School of Engineering. He focused on neuroscience topics, including neurotechnology such as brain-computer interfaces. On 21 January 2023, he died after a long battle with pancreatic cancer. According to Google Scholar, he amassed an h-index of 79.
Dora Angelaki is a Professor of Neuroscience in the New York University Tandon School of Engineering. She previously held the Wilhelmina Robertson Professorship of Neuroscience at the Baylor College of Medicine. She looks at multi-sensory information flow between subcortical and cortical areas of the brain. Her research interests include spatial navigation and decision-making circuits. She was elected to the National Academy of Sciences in 2014.