Reciprocal inhibition

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Reciprocal inhibition is a neuromuscular process in which muscles on one side of a joint relax to allow the contraction of muscles on the opposite side, enabling smooth and coordinated movement. [1] This concept, introduced by Charles Sherrington, a pioneering neuroscientist, is also referred to as reflexive antagonism in some allied health fields. Sherrington, one of the founding figures in neurophysiology, observed that when the central nervous system signals an agonist muscle to contract, inhibitory signals are sent to the antagonist muscle, encouraging it to relax and reduce resistance. This mechanism, known as reciprocal inhibition, is essential for efficient movement and helps prevent muscle strain by balancing forces around a joint. [2]

Contents

Mechanics

Joints are controlled by two opposing sets of muscles called extensors and flexors, that work in synchrony for smooth movement. When a muscle spindle is stretched, the stretch reflex is activated, and the opposing muscle group must be inhibited to prevent it from working against the contraction of the homonymous muscle. This inhibition is accomplished by the actions of an inhibitor interneuron in the spinal cord. [3]

The afferent of the muscle spindle bifurcates in the spinal cord. One branch innervates the alpha motor neuron that causes the homonymous muscle to contract, producing the reflex. The other branch innervates the inhibitory interneuron, which then innervates the alpha motor neuron that synapses onto the opposing muscle. Because the interneuron is inhibitory, it prevents the opposing alpha motor neuron from firing, thereby reducing the contraction of the opposing muscle. Without this reciprocal inhibition, both groups of muscles might contract simultaneously and work against each other.

If opposing muscles were to contract at the same time, a muscle tear can occur. This may occur during physical activities such as running, during which opposing muscles engage and disengage sequentially to produce coordinated movement. Reciprocal inhibition facilitates ease of movement and is a safeguard against injury. However, if a "misfiring" of motor neurons occurs, causing simultaneous contraction of opposing muscles, a tear can occur. For example, if the quadriceps femoris and hamstring contract simultaneously at a high intensity, the stronger muscle (traditionally the quadriceps) overpowers the weaker muscle group (hamstrings). This can result in a common muscular injury known as a pulled hamstring, more accurately called a muscle strain.

Duration

The phenomenon is fleeting, incomplete, and weak. For example, when the triceps brachii is stimulated, the biceps is reflexively inhibited. The incompleteness of the effect is related to postural and functional tone. Also, some reflexes in vivo are polysynaptic, with entire muscle groups responding to noxious stimuli.

As the body ages, the control of voluntary inhibition decreases in conjunction with the torque of the synapse as joints stiffen and their motor output is reduced. However, this reduction in ability tends to be insignificant. [4]

Application in physical therapy

Reciprocal inhibition is the basic original notion behind indirect muscle energy techniques. While this notion is now understood to be incomplete, the clinical mechanism of reflexive antagonism continues to be useful in physical therapy.

Muscle energy techniques that use reflexive antagonism, such as rapid deafferentation techniques, are medical guideline techniques and protocols that make use of reflexive pathways and reciprocal inhibition as a means of switching off inflammation, pain, and protective spasm for entire synergistic muscle groups or singular muscles and soft tissue structures.

Related Research Articles

Spasticity is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles.

<span class="mw-page-title-main">Motor neuron</span> Nerve cell sending impulse to muscle

A motor neuron is a neuron whose cell body is located in the motor cortex, brainstem or the spinal cord, and whose axon (fiber) projects to the spinal cord or outside of the spinal cord to directly or indirectly control effector organs, mainly muscles and glands. There are two types of motor neuron – upper motor neurons and lower motor neurons. Axons from upper motor neurons synapse onto interneurons in the spinal cord and occasionally directly onto lower motor neurons. The axons from the lower motor neurons are efferent nerve fibers that carry signals from the spinal cord to the effectors. Types of lower motor neurons are alpha motor neurons, beta motor neurons, and gamma motor neurons.

<span class="mw-page-title-main">Muscle spindle</span> Innervated muscle structure involved in reflex actions and proprioception

Muscle spindles are stretch receptors within the body of a skeletal muscle that primarily detect changes in the length of the muscle. They convey length information to the central nervous system via afferent nerve fibers. This information can be processed by the brain as proprioception. The responses of muscle spindles to changes in length also play an important role in regulating the contraction of muscles, for example, by activating motor neurons via the stretch reflex to resist muscle stretch.

<span class="mw-page-title-main">Grey columns</span> Three columns of grey matter within the spinal cord

The grey columns are three regions of the somewhat ridge-shaped mass of grey matter in the spinal cord. These regions present as three columns: the anterior grey column, the posterior grey column, and the lateral grey column, all of which are visible in cross-section of the spinal cord.

<span class="mw-page-title-main">Reflex arc</span> Neural pathway which controls a reflex

A reflex arc is a neural pathway that controls a reflex. In vertebrates, most sensory neurons do not pass directly into the brain, but synapse in the spinal cord. This allows for faster reflex actions to occur by activating spinal motor neurons without the delay of routing signals through the brain. The brain will receive the input while the reflex is being carried out and the analysis of the signal takes place after the reflex action.

Renshaw cells are inhibitory interneurons found in the gray matter of the spinal cord, and are associated in two ways with an alpha motor neuron.

<span class="mw-page-title-main">Patellar reflex</span> Monosynaptic reflex

The patellar reflex, also called the knee reflex or knee-jerk, is a stretch reflex which tests the L2, L3, and L4 segments of the spinal cord. Many animals, most significantly humans, have been seen to have the patellar reflex, including dogs, cats, horses, and other mammalian species.

<span class="mw-page-title-main">Caridoid escape reaction</span> Innate escape mechanism by crustaceans

The caridoid escape reaction, also known as lobstering or tail-flipping, is an innate escape behavior in marine and freshwater eucarid crustaceans such as lobsters, krill, shrimp and crayfish.

<span class="mw-page-title-main">Upper motor neuron</span> Neurons in the brain that carry signals to lower motor neurons

Upper motor neurons (UMNs) is a term introduced by William Gowers in 1886. They are found in the cerebral cortex and brainstem and carry information down to activate interneurons and lower motor neurons, which in turn directly signal muscles to contract or relax. UMNs represent the major origin point for voluntary somatic movement.

Lower motor neurons (LMNs) are motor neurons located in either the anterior grey column, anterior nerve roots or the cranial nerve nuclei of the brainstem and cranial nerves with motor function. Many voluntary movements rely on spinal lower motor neurons, which innervate skeletal muscle fibers and act as a link between upper motor neurons and muscles. Cranial nerve lower motor neurons also control some voluntary movements of the eyes, face and tongue, and contribute to chewing, swallowing and vocalization. Damage to the lower motor neurons can lead to flaccid paralysis, absent deep tendon reflexes and muscle atrophy.

<span class="mw-page-title-main">Gamma motor neuron</span> Lower motor neuron involved in muscle contraction

A gamma motor neuron, also called gamma motoneuron, or fusimotor neuron, is a type of lower motor neuron that takes part in the process of muscle contraction, and represents about 30% of (Aγ) fibers going to the muscle. Like alpha motor neurons, their cell bodies are located in the anterior grey column of the spinal cord. They receive input from the reticular formation of the pons in the brainstem. Their axons are smaller than those of the alpha motor neurons, with a diameter of only 5 μm. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles. However, their role is important in keeping muscle spindles taut, thereby allowing the continued firing of alpha neurons, leading to muscle contraction. These neurons also play a role in adjusting the sensitivity of muscle spindles.

Central pattern generators (CPGs) are self-organizing biological neural circuits that produce rhythmic outputs in the absence of rhythmic input. They are the source of the tightly-coupled patterns of neural activity that drive rhythmic and stereotyped motor behaviors like walking, swimming, breathing, or chewing. The ability to function without input from higher brain areas still requires modulatory inputs, and their outputs are not fixed. Flexibility in response to sensory input is a fundamental quality of CPG-driven behavior. To be classified as a rhythmic generator, a CPG requires:

  1. "two or more processes that interact such that each process sequentially increases and decreases, and
  2. that, as a result of this interaction, the system repeatedly returns to its starting condition."
<span class="mw-page-title-main">Intrafusal muscle fiber</span> Skeletal muscle fibers

Intrafusal muscle fibers are skeletal muscle fibers that serve as specialized sensory organs (proprioceptors). They detect the amount and rate of change in length of a muscle. They constitute the muscle spindle, and are innervated by both sensory (afferent) and motor (efferent) fibers.

The rectus femoris muscle is one of the four quadriceps muscles of the human body. The others are the vastus medialis, the vastus intermedius, and the vastus lateralis. All four parts of the quadriceps muscle attach to the patella by the quadriceps tendon.

<span class="mw-page-title-main">Scratch reflex</span> Response to activation of sensory neurons

The scratch reflex is an automatic response to the activation of sensory neurons located on the surface of the body. Sensory neurons can be activated via stimulation, such as a parasite on the body, but can also be activated by responding to a chemical stimulus that produces an itching sensation. During a scratch reflex, a limb reaches toward and rubs against the site on the body surface that has been stimulated. The scratch reflex has been extensively studied to understand the functioning of neural networks in vertebrates. Despite decades of research, key aspects of the scratch reflex are still unknown, such as the neural mechanisms by which the reflex is terminated.

Muscle Energy Techniques (METs) describes a broad class of manual therapy techniques directed at improving musculoskeletal function or joint function, and improving pain. METs are commonly used by manual therapists, physical therapists, occupational therapist, chiropractors, athletic trainers, osteopathic physicians, and massage therapists. Muscle energy requires the patient to actively use his or her muscles on request to aid in treatment. Muscle energy techniques are used to treat somatic dysfunction, especially decreased range of motion, muscular hypertonicity, and pain.

<span class="mw-page-title-main">Alpha motor neuron</span> Large lower motor neurons of the brainstem and spinal cord

Alpha (α) motor neurons (also called alpha motoneurons), are large, multipolar lower motor neurons of the brainstem and spinal cord. They innervate extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. Alpha motor neurons are distinct from gamma motor neurons, which innervate intrafusal muscle fibers of muscle spindles.

The Golgi tendon reflex (also called inverse stretch reflex, autogenic inhibition, tendon reflex) is an inhibitory effect on the muscle resulting from the muscle tension stimulating Golgi tendon organs (GTO) of the muscle, and hence it is self-induced. The reflex arc is a negative feedback mechanism preventing too much tension on the muscle and tendon. When the tension is extreme, the inhibition can be so great it overcomes the excitatory effects on the muscle's alpha motoneurons causing the muscle to suddenly relax. This reflex is also called the inverse myotatic reflex, because it is the inverse of the stretch reflex.

<span class="mw-page-title-main">Spinal interneuron</span> Interneuron relaying signals between sensory and motor neurons in the spinal cord

A spinal interneuron, found in the spinal cord, relays signals between (afferent) sensory neurons, and (efferent) motor neurons. Different classes of spinal interneurons are involved in the process of sensory-motor integration. Most interneurons are found in the grey column, a region of grey matter in the spinal cord.

<span class="mw-page-title-main">Cutaneous reflex in human locomotion</span>

Cutaneous, superficial, or skin reflexes, are activated by skin receptors and play a valuable role in locomotion, providing quick responses to unexpected environmental challenges. They have been shown to be important in responses to obstacles or stumbling, in preparing for visually challenging terrain, and for assistance in making adjustments when instability is introduced. In addition to the role in normal locomotion, cutaneous reflexes are being studied for their potential in enhancing rehabilitation therapy (physiotherapy) for people with gait abnormalities.

References

  1. ↑ Carlin, Eleanor J. (1964-11-01). "Massage: Principles and Techniques". Physical Therapy. 44 (11): 161. doi:10.1093/ptj/44.11.1048. ISSN   0031-9023.
  2. ↑ Callister, Robert J.; Brichta, Alan M.; Schaefer, Andreas T.; Graham, Brett A.; Stuart, Douglas G. (2020-05-01). "Pioneers in CNS inhibition: 2. Charles Sherrington and John Eccles on inhibition in spinal and supraspinal structures". Brain Research. 1734: 146540. doi:10.1016/j.brainres.2019.146540. ISSN   1872-6240. PMID   31704081.
  3. ↑ Crone, C. (1993). "Reciprocal inhibition in man". Danish Medical Bulletin. 40 (5): 571–581. ISSN   0907-8916. PMID   8299401.
  4. ↑ Hortobágyi, Tibor; del Olmo, M. Fernandez; John C. Rothwell (2006-05-01). "Age reduces cortical reciprocal inhibition in humans". Experimental Brain Research. 171 (3): 322–329. doi:10.1007/s00221-005-0274-9. ISSN   1432-1106.

Further reading

Bibliography

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