Deth attended State University of New York at Buffalo, where he graduated in 1970 with a bachelor's degree in pharmacy. In 1975, Deth obtained his PhD from the University of Miami with a thesis entitled "The relative contribution of Ca++ influx and intracellular Ca++ release in the drug induced contraction of the rabbit aorta."[2][3]
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Deth's research primarily focuses on how D4 dopamine receptors may impact schizophrenia and attention.[citation needed] He has focused on understanding the molecular basis of transmembrane signaling by G protein-coupled receptors, the study of their structure using three-dimensional molecular graphics, and modeling how the binding of various drugs causes a shift in their molecular form.[4]
Deth has characterized[clarification needed] the conformation-dependent participation of D4 dopamine receptors in the process of phospholipidmethylation, and claimed that different states of methylation yield varying degrees of spontaneous activity of G protein coupling. He has theorized that these processes are involved in the neural mechanisms of attention.[5] Deth has claimed that insulin-like growth factor-1 (IGF-1) and dopamine stimulate folate-dependent methylation pathways in neuronal cells, while compounds like ethanol, thiomersal, and heavy metals inhibit these same biochemical pathways at low concentrations resembling those found following vaccination or other sources of exposure. An enzyme mediating methylation, methionine synthase, uses an active form of vitamin B12 to complete its chemical function.[medical citation needed] Deth has claimed thiomersal interferes with the conversion of dietary forms of B12 into the active form, impeding DNA methylation and disrupting mercury detoxification and some normal gene actions.[6]
Based on this research, Deth has falsely speculated that the thiomersal contained in some vaccines triggers autism in genetically predisposed children; he has also contended that the body's response to thiomersal is a hormetic one, in which low-level exposure to the substance causes a beneficial effect.[7] He played an active role in the initial confusion about the suggested relationship thiomersal and vaccines, testifying twice to Congress about his views.[when?][citation needed] This aspect of his research attracted such controversy that a dean at Northeastern University once[when?] wrote a letter to Deth telling him to stop.[8]
In 2015, Deth co-authored a paper that alleged researchers who did not find a link between thiomersal and autism were being influenced by those with an economic interest in proving thiomersal's safety. The paper compared such researchers to those manipulated by tobacco companies into falsely vouching for the safety of their products.[9] Among Deth's co-authors were discredited anti-vaccine activists[10]Mark and David Geier.[9] In 2017, the journal Science and Engineering Ethics retracted the paper, claiming several of its authors, including Deth and the Geiers, had not adequately disclosed their own conflicts of interest.[11]
↑Stanley, Karen (1 July 2014). "Richard Deth Retires in 2014". School of Pharmacy and Pharmaceutical Sciences. Northeastern University. Archived from the original on 13 December 2021. Retrieved 22 January 2022.
↑The relative contribution of Ca++ influx and intracellular Ca++ release in the drug induced contraction of the rabbit aorta. OCLC1675020.
↑Waly, M; Olteanu, H; Banerjee, R; Choi, S-W; Mason, J B; Parker, B S; Sukumar, S; Shim, S; Sharma, A; Benzecry, J M; Power-Charnitsky, V-A; Deth, R C (2004-01-27). "Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal". Molecular Psychiatry. 9 (4). Springer: 358–370. doi:10.1038/sj.mp.4001476. ISSN1359-4184. PMID14745455.
↑Price, Cristofer S.; Thompson, William W.; Goodson, Barbara; Weintraub, Eric S.; Croen, Lisa A.; Hinrichsen, Virginia L.; Marcy, Michael; Robertson, Anne; Eriksen, Eileen; Lewis, Edwin; Bernal, Pilar; Shay, David; Davis, Robert L.; DeStefano, Frank (2010-10-01). "Prenatal and Infant Exposure to Thimerosal From Vaccines and Immunoglobulins and Risk of Autism". Pediatrics. 126 (4): 656–664. doi:10.1542/peds.2010-0309. ISSN0031-4005. PMID20837594.
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