Anthony James Pawson was a British-born Canadian scientist whose research revolutionised the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins.
The Canadian Historical Association is a Canadian organization founded in 1922 for the purposes of promoting historical research and scholarship. It is a bilingual, not-for-profit, charitable organization, the largest of its kind in Canada. According to the Association, it "seeks to encourage the integration of historical knowledge and perspectives in both the scholarly and public spheres, to ensure the accessibility of historical resources, and to defend the rights and freedoms of emerging and professional historians in the pursuit of historical inquiry as well as those of history degree holders who utilize the analytical, research, communication, and writing skills they acquired during their studies to pursue a variety of career paths inside or outside of academia."
James Edgar Till is a University of Toronto biophysicist, best known for demonstrating – with Ernest McCulloch – the existence of stem cells.
Robert Laing Noble was a Canadian physician who was involved in the discovery of vinblastine.
Tak Wah Mak, is a Canadian medical researcher, geneticist, oncologist, and biochemist. He first became widely known for his discovery of the T-cell receptor in 1983 and pioneering work in the genetics of immunology. In 1995, Mak published a landmark paper on the discovery of the function of the immune checkpoint protein CTLA-4, thus opening the path for immunotherapy/checkpoint inhibitors as a means of cancer treatment. Mak is also the founder of Agios Pharmaceuticals, whose lead compound, IDHIFA®, was approved by the FDA for acute myeloid leukemia in August 2017, becoming the first drug specifically targeting cancer metabolism to be used for cancer treatment. He has worked in a variety of areas including biochemistry, immunology, and cancer genetics.
The Canadian Cancer Society is Canada's largest national cancer charity and the largest national charitable funder of cancer research in Canada.
Victor Ling, is a Canadian researcher in the field of medicine. Ling's research focuses on drug resistance in cancer. He is best known for his discovery of P-glycoprotein, one of the proteins responsible for multidrug resistance.
Robert Allan Weinberg is a biologist, Daniel K. Ludwig Professor for Cancer Research at Massachusetts Institute of Technology (MIT), director of the Ludwig Center of the MIT, and American Cancer Society Research Professor. His research is in the area of oncogenes and the genetic basis of human cancer.
John Edgar Dick is Canada Research Chair in Stem Cell Biology, Senior Scientist at the Princess Margaret Cancer Centre, University Health Network and Professor in the Department of Molecular Genetics at the University of Toronto in Canada. Dick is credited with first identifying cancer stem cells in certain types of human leukemia. His revolutionary findings highlighted the importance of understanding that not all cancer cells are the same and thus spawned a new direction in cancer research. Dick is also known for his demonstration of a blood stem cell's ability to replenish the blood system of a mouse, his development of a technique to enable an immune-deficient mouse to carry and produce human blood, and his creation of the world's first mouse with human leukemia.
Connie Jean Eaves, CorrFRSE, is a Canadian biologist with significant contributions to cancer and stem cell research. Eaves is a professor generics of genetics at the University of British Columbia and is also the co-founder with Allen C Eaves of Terry Fox Laboratory.
Carol E. Cass is a Canadian research scientist. From 2003 to 2010, Cass served as director of Alberta's Cross Cancer Institute. She is Canada Research Chair in oncology at the University of Alberta and was elected a Fellow of the Royal Society of Canada and Canadian Academy of Health Sciences.
Nahum Sonenberg, is an Israeli Canadian microbiologist and biochemist. He is a James McGill professor of biochemistry at McGill University in Montreal, Quebec, Canada. He was an HHMI international research scholar from 1997 to 2011 and is now a senior international research scholar. He is best known for his seminal contributions to our understanding of translation, and notable for the discovery of the mRNA 5' cap-binding protein, eIF4E, the rate-limiting component of the eukaryotic translation apparatus.
Harald zur Hausen NAS EASA APS was a German virologist. He carried out research on cervical cancer and discovered the role of papilloma viruses in cervical cancer, for which he received the Nobel Prize in Physiology or Medicine in 2008. He was chairman of the German Cancer Research Center in Heidelberg.
Richard "Dick" P. Hill is a scientist. His work in Applied Molecular Oncology has led to advanced cancer treatments.
Brian J. Druker is a physician-scientist at Oregon Health & Science University (OHSU), in Portland, Oregon. He is the director of OHSU's Knight Cancer Institute, JELD-WEN Chair of Leukemia Research, Associate Dean for Oncology in the OHSU School of Medicine, and professor of medicine.
Alan Bernstein is Professor Emeritus at the University of Toronto and President Emeritus of CIFAR, where he served as President and CEO from 2012 to 2022. A Distinguished Fellow at the Munk School of Global Affairs and Public Policy, he is also a Fellow and Member of the Standing Committee for Science Planning at the International Science Council (2022-2025). Bernstein is recognized as a leader in health research, science policy, mentorship and organizational leadership.
Frank L. Graham is a Canadian biologist, having been a Distinguished University Professor at McMaster University.
R. Mark Henkelman is a Canadian biophysics researcher in the field of medical imaging, now retired, who was appointed as a Fellow of the Royal Society of Canada (2005) and the Order of Canada (2019) in recognition of his pioneering contributions to the field of magnetic resonance imaging.
Morag Park is a breast cancer and genomics researcher at the McGill University Health Centre. Park is known for her work on the combination of genetic and epigenetic alterations that result in breast cancer progression and receptor tyrosine kinases involved in cancer. More recently, she has worked in as primary co-researcher of a Quebec cancer biobank network that creates tumor models derived from patients, allowing for research into why individual patients respond well or poorly to cancer therapies. She is currently a professor in the Gerald Bronfman Department of Oncology and a member of the Faculty of Medicine and Health Sciences at McGill University.
