Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals. SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype.
The National Institute for Medical Research (NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC);
The Francis Crick Medal and Lecture is a prize lecture of the Royal Society established in 2003 with an endowment from Sydney Brenner, the late Francis Crick's close friend and former colleague. It is delivered annually in biology, particularly the areas which Francis Crick worked, and also to theoretical work. The medal is also intended for young scientists, i.e. under 40, or at career stage corresponding to being under 40 should their career have been interrupted.
The Cancer Research UK London Research Institute (LRI) was a biological research facility which conducted research into the basic biology of cancer.
Established in 1986, the Louis-Jeantet Prizes are funded by the Fondation Louis-Jeantet and awarded each year to experienced researchers who have distinguished themselves in the field of biomedical research in one of the member states of the Council of Europe. They are not intended solely as the recognition of work that has been completed, but also to encourage the continuation of innovative research projects. The prizes are awarded to fully active researchers whose scientific efforts are focused on biomedical research. When the research being recognised is close to practical applications for combating illnesses affecting humankind, one of the Louis-Jeantet Prizes converts into a Jeantet-Collen Prize for Translational Medicine, supported by generous donations from the Désiré Collen Stichting.
Transcription factor SOX-3 is a protein that in humans is encoded by the SOX3 gene. This gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic brain development and in determination of cell fate. The encoded protein acts as a transcriptional activator.
Sir John James Skehel, is a British virologist and Emeritus scientist at the Francis Crick Institute in London. From 1987 to 2006 he was director of the National Institute of Medical Research (NIMR) at Mill Hill which was incorporated into the Crick Institute in 2016.
Stephen Craig West FRS is a British biochemist and molecular biologist specialising in research on DNA recombination and repair. He is known for pioneering studies on genome instability diseases including cancer. West obtained his BSc in 1974, and his PhD in 1977, both from Newcastle University. He is currently a Principal Group Leader at the Francis Crick Institute in London. He is an honorary Professor at University College London, and at Imperial College London. In recognition of his work he was awarded the Louis-Jeantet Prize for Medicine in 2007, is a fellow of the Royal Society, the Academy of Medical Sciences, an International Member of the National Academy of Sciences, and an International Honorary Member of the American Academy of Arts and Sciences. He received the 2022 Royal Medal for 'discovering and determining the functions of key enzymes that are essential for DNA recombination, repair and the maintenance of genomes'.
Peter Neville Goodfellow, is a British geneticist best known for his work on sex determination and the SRY gene that encodes testis determining factor. He was Arthur Balfour Professor of Genetics at the University of Cambridge from 1992 to 1996.
Sir Peter John Ratcliffe, FRS, FMedSci is a British physician-scientist who is trained as a nephrologist. He was a practising clinician at the John Radcliffe Hospital, Oxford and Nuffield Professor of Clinical Medicine and head of the Nuffield Department of Clinical Medicine at the University of Oxford from 2004 to 2016. He has been a Fellow of Magdalen College, Oxford since 2004. In 2016 he became Clinical Research Director at the Francis Crick Institute, retaining a position at Oxford as a member of the Ludwig Institute of Cancer Research and director of the Target Discovery Institute, University of Oxford.
Sir James Cuthbert Smith is an Emeritus Scientist at the Francis Crick Institute, Honorary Fellow of Christ's College, Cambridge and President of the Council at the Zoological Society of London.
Frank Uhlmann FRS is a group leader at the Francis Crick Institute in London.
Andrea Ballabio is an Italian scientist and academic professor. He is founder-director of the Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; professor of medical genetics at the University of Naples Federico II, Naples, Italy and visiting professor of genetics at Baylor College of Medicine in Houston, Texas, U.S. and at the University of Oxford, UK. He is also the former director of the Telethon Institute of Genetics and Medicine in Milan, Italy. He is the recipient of 2016 Louis-Jeantet Prize for Medicine for his contribution to understanding the molecular mechanisms controlling the function of lysosomes in health and disease.
Dirk Bootsma was a Dutch geneticist. He was a professor at Erasmus University Rotterdam from 1969 and 2002. He and his research group discovered the cause of chronic myelogenous leukemia and furthered the understanding of the nucleotide excision repair.
Sir Richard Henry Treisman is a British scientist specialising in the molecular biology of cancer. Treisman is a director of research at the Francis Crick Institute in London.
Robert Charles Swanton is a British physician scientist specialising in oncology and cancer research. Swanton is a senior group leader at London's Francis Crick Institute, Royal Society Napier Professor in Cancer and thoracic medical oncologist at University College London and University College London Hospitals, co-director of the Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, and Chief Clinician of Cancer Research UK.
Peter Anthony Koopman is an Australian biologist best known for his role in the discovery and study of the mammalian Y-chromosomal sex-determining gene, Sry.
John Francis Xavier Diffley is an American biochemist and Associate Research Director at the Francis Crick Institute. He is known for his contributions to the understanding of how DNA replication is initiated, and how it is subsequently regulated throughout the cell cycle and in response to DNA damage.
Caetano Maria Pacheco Pais dos Reis e Sousa is a Portuguese scientist who is a senior group leader at the Francis Crick Institute and a professor of Immunology at Imperial College London.
Four Core Genotypes (FCG) mice are laboratory mice produced by genetic engineering that allow biomedical researchers to determine if a sex difference in phenotype is caused by effects of gonadal hormones or sex chromosome genes. The four genotypes include XX and XY mice with ovaries, and XX and XY mice with testes. The comparison of XX and XY mice with the same type of gonad reveals sex differences in phenotypes that are caused by sex chromosome genes. The comparison of mice with different gonads but the same sex chromosomes reveals sex differences in phenotypes that are caused by gonadal hormones.
