Related Research Articles
Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals. SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype.
SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box. This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species.
High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair.
SRY -box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells.
Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.
Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene.
Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.
Transcription factor SOX-3 is a protein that in humans is encoded by the SOX3 gene. This gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic brain development and in determination of cell fate. The encoded protein acts as a transcriptional activator.
Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.
Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.
Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.
Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene.
Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.
Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.
Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.
SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.
Transcription factor SOX-14 is a protein that in humans is encoded by the SOX14 gene.
Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene. It is a member of the Sox gene family of transcription factors.
SOX1 is a gene that encodes a transcription factor with a HMG-box DNA-binding domain and functions primarily in neurogenesis. SOX1, SOX2 and SOX3, members of the SOX gene family, contain transcription factors related to SRY, the testis-determining factor.
SRY-box 7 is a protein that in humans is encoded by the SOX7 gene.
References
- ↑ "Entrez Gene: SRY (sex determining region Y)-box 30" . Retrieved 2014-05-29.
