Sepsis Six

The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with sepsis.^{[ citation needed ]}

Drawn from international guidelines that emerged from the Surviving Sepsis Campaign ^{[1] [2]} the Sepsis Six was developed by The UK Sepsis Trust. ^[3] (Daniels, Nutbeam, Laver) in 2006 as a practical tool to help healthcare professionals deliver the basics of care rapidly and reliably.

In 2011, The UK Sepsis Trust published evidence that use of the Sepsis Six was associated with a 50% reduction in mortality, a decreased length of stay in hospital, and fewer intensive care days. ^[4] Though the authors urge caution in a causal interpretation of these findings.^{[ citation needed ]}

The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis:^{[ citation needed ]}

1. Titrate oxygen to a saturation target of 94%
2. Take blood cultures and consider source control
3. Administer empiric intravenous antibiotics
4. Measure serial serum lactates
5. Start intravenous fluid resuscitation
6. Commence accurate urine output measurement.

References

1. R. Phillip, Dellinger; Mitchell M., Levy; Jean M., Carlet; Julian, Bion; Margaret M., Parker; Roman, Jaeschke; Konrad, Reinhart; Derek C., Angus; Christian, Brun-Buisson; Richard, Beale; et al. (1 January 2008). Buchanan, Timothy G.; Tosta, Sophie M.; Retford, Lynn; Goldberg, Jill; Less, Sarah; Drake, Madison; Maslove, David M.; Deutschmann, Clifford S.; Prough, Donald S. (eds.). "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008". Critical Care Medicine . 36 (1). Society of Critical Care Medicine/Lippincott Williams & Wilkins: 296–327. doi:10.1097/01.ccm.0000298158.12101.41. ISSN   0090-3493. LCCN   73647665. OCLC   772657699. PMID   18158437. S2CID   220581728.
2. Rhodes, Andrew; Evans, Laura E.; Alhazzani, Waleed; Levy, Mitchell M.; Antonelli, Massimo; Ferrer, Ricard; Kumar, Anand; Sevransky, Jonathan E.; Sprung, Charles L.; Nunnally, Mark E.; et al. (1 March 2017). Buchanan, Timothy G.; Tosta, Sophie M.; Retford, Lynn; Goldberg, Jill; Less, Sarah; Drake, Madison; Maslove, David M.; Deutschmann, Clifford S.; Prough, Donald S. (eds.). "Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016". Critical Care Medicine . 45 (3). Society of Critical Care Medicine/Lippincott Williams & Wilkins: 486–452. doi:10.1097/CCM.0000000000002255. ISSN   0090-3493. LCCN   73647665. OCLC   772657699. PMID   28098591. S2CID   52827184. Archived from the original on 1 February 2020. Retrieved 22 June 2021.
3. "Home « The UK Sepsis Trust The UK Sepsis Trust". sepsistrust.org. Retrieved 2014-04-22.
4. Daniels, Ron; Nutbeam, Tim; McNamara, Georgina; Galvin, Clare (2011). Godlee, Fiona; Abbasi, Kamran; Bloom, Theodora; Loder, Elizabeth; Coombes, Rebecca; Dobson, Juliet; Kmietowicz, Zosia; Simpson, Paul; Tonks, Alison; Moberly, Tom; et al. (eds.). "The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study". Emergency Medicine Journal. 28 (6). London, England, United Kingdom of Great Britain: BMJ Publishing Group Ltd/British Medical Association: 507–512. doi:10.1136/emj.2010.095067. ISSN   1472-0213. JSTOR   09598138. LCCN   97640199. OCLC   32595642. PMID   21036796. S2CID   26693613. Archived from the original on 2 June 2018.