The article's lead section may need to be rewritten.(June 2023) |
Abbreviation | SHIELD IL |
---|---|
Founders | Tim Killeen |
Founded at | Champaign-Urbana, Illinois |
Type | Governmental Organization |
Legal status | SHIELD Deployment Unit of the University of Illinois System |
Purpose | To keep Illinois open by providing fast, accurate, and readily available SARS-CoV-2 testing throughout the state |
Headquarters | Champaign-Urbana, Illinois |
Services | SARS-CoV-2 testing and variant identification |
Managing Director | Ronald Watkins, Associate Vice President for Strategic Initiatives at the University of Illinois System |
Parent organization | University of Illinois System |
Website | www.shieldillinois.com |
SHIELD Illinois is the SHIELD Deployment Unit of the University of Illinois System charged with administering the covidSHIELD SARS-CoV-2 assay throughout the State of Illinois. SHIELD Illinois performed over 7.2 million SARS-CoV-2 assays during its initial program. This represents 12% of all SARS-CoV-2 tests in Illinois and more tests than 24 entire states. [1]
The University of Illinois at Urbana-Champaign (UIUC) faced a problem when the global spread of SARS-CoV-2 and COVID-19 led to the closure of its campus in April 2020. [2] Campus leaders wanted to find a way to resume normal activities [3] and realized that frequent, accurate testing of the community would be key. However, there was no existing test that was non-invasive, inexpensive, and quick enough to provide results in time for the campus to take action. UIUC decided to take on this challenge and within a few months, researchers had developed the covidSHIELD assay, a saliva-based PCR test that eliminated the costly and time-consuming RNA extraction step used in other SARS-CoV-2 tests. [4] This fast, accurate, and affordable test [5] allowed UIUC to start twice weekly testing of its entire campus population, [6] which helped to reduce the positivity rate on campus and in the surrounding community. [7] The success of the SHIELD program at UIUC led the University of Illinois System to offer this service to other entities in Illinois, [8] resulting in the creation of the SHIELD Deployment Unit aka SHIELD Illinois.
To run this new startup, University administration tapped then Associate Dean for Strategy and Innovation at the Gies College of Business on the Urbana-Champaign campus, Ron Watkins. Watkins brought on board three former iMBA students to form the core team along with individuals loaned to SHIELD Illinois by other system units. [9]
SHIELD Illinois was originally intended to be a facilitator, assisting laboratories in preparing to use the covidSHIELD assay and advising colleges, universities, and other organizations on how to collect specimens. SHIELD Illinois would also provide the technology needed to transmit orders to the lab and results back to the collecting agency. It was estimated that the program would have 50 testing locations and collect 1.5 million tests over a six-month period. Over time, SHIELD Illinois's role expanded beyond its original advisory function, and it became involved in the logistics of running both laboratories and collection sites. However, the estimated number of labs and locations remained the same.
This changed in March 2021, when the University of Illinois System entered into an Intergovernmental Agreement with the Illinois Department of Public Health to offer testing to every school district, community college, and public university in Illinois, as well as community testing sites for the general public throughout the state. There are 853 school districts covering 3,977 with 1.9 million students [10] in Illinois.
As of October 2022, the company had performed over 6.5 million tests at over 1,700 sites in Illinois, including the governor's office, the state legislature, and the United States District Court for the Northern District of Illinois; engaged 12 CLIA or CAP-certified laboratories; and built a transportation network covering 80,000 square miles. Tests performed by SHIELD Illinois represent 12% of all SARS-CoV-2 tests in Illinois and more tests than 24 entire states. [1] To achieve this, SHIELD Illinois ultimately grew from a team of 30 to over 300 employees and more than 1,000 contractors. [11]
In October 2021, SHIELD and IDPH partnered with the United States Department of Health and Human Services' (HHS) Midwest COVID-19 Testing Coordination Center (MCC) to bring funding and resources from HHS "Operation Expanded Testing" to Illinois. This not only provided additional funding to Illinois but also provided testing to remote rural schools that previously were unable to manage the logistics of testing operations. [12]
With the COVID-19 pandemic waning, SHIELD Illinois performed its last SARS-CoV-2 assay on June 30, 2023.
To meet the testing demand both in terms of turnaround times and specimens processed per day, SHIELD Illinois created an extensive logistics network consisting of The Depot (Chicagoland Central distribution hub), funnel sites (drop points for collection sites located far from The Depot or a central Illinois laboratory), a fleet of 40 vehicles, 12 geographically disparate labs, and a courier network covering 80,000 square miles.
A peer-reviewed research study published June, 2022 in the journal Nature Communications showed the effectiveness of fast/frequent testing using the novel low-cost and scalable saliva-based RT-qPCR assay for SARS-CoV-2 that bypasses RNA extraction called covidSHIELD reduced mortality in the community more than 4-fold relative to expected. [17]
SHIELD Illinois piloted the "Test to Stay" program developed in cooperation with the Illinois Department of Public Health. Later endorsed by the CDC, Test to Stay allows unvaccinated students, faculty, and staff who have been exposed to SARS-CoV-2 positive individuals to remain in the classroom providing they wear a mask and test on days one, three, five, and seven following exposure. This program prevented the need to quarantine and exclude entire classes when one student in the group tests positive. During the pilot period alone, which only covered a population of 1,035 students and staff, "8,152 learning days were saved among close contacts." [18]
In February 2019, SHIELD Illinois partnered with the United States District Court for the Northern District of Illinois to provide SARS-CoV-2 screening to jurors, attorneys, employees, and other courthouse visitors. The program required all jurors to test with SHIELD Illinois before reporting for voir dire while employees were tested weekly. This partnership allowed jury trials to resume in the Northern District while maintaining a safe and healthy working environment for everyone involved. [19]
SHIELD Illinois started testing visitors, staff, and members of the Illinois General Assembly in January 2021 which coincided with the legislators' return to in-person attendance in Springfield for the legislative session. Testing was mandatory for non-vaccinated visitors and capitol staff. Testing was optional for members.
After 17 new cases were diagnosed in one week, the Oak Park Health Department forced Oak Park River Forest High School to cancel all extracurricular activities on December 3, 2021 and hinted toward a future move to suspend in-person learning. Oak Park Public Health Director Dr. Theresa Chapple expressed concerns that "only about 100 to 200 students" were tested each week which left the department blind to the actual size of the outbreak. [20] SHIELD Illinois was engaged by the district on Saturday, December 4 about the possibility of testing the entire school population in one day. SHIELD rallied every employee trained to collect specimens, including executive leadership, accounting specialists, and logistics team members. Monday, December 6, 2021, SHIELD Illinois collected specimens from 1,651 students, faculty, and staff. This initial round of testing identified 20 positive patients. [21] The health department allowed extracurricular activities to resume on December 7, 2021. [22] SHIELD Illinois repeated the same process on December 9. This time testing 1,396 faculty, staff, and students--identifying an additional 3 positive cases. [21]
While SHIELD Illinois provided free SARS-CoV-2 testing to most school districts throughout Illinois and submitted a proposal to test Chicago Public Schools ("CPS"), CPS ultimately chose Massachusetts-based Thermo Fisher Scientific as its testing vendor. [23] Despite this, when logistical issues related to the Omicron surge led to test result delays, 25,000 specimens rejected as invalid, and a vote by the Chicago Teachers Union ("CTU") to postpone the start of school in January of 2022, [24] SHIELD Illinois provided CPS with SHIELD's entire stockpile of over 300,000 rapid antigen tests. This allowed CPS to achieve testing levels at which CTU felt comfortable returning to the classroom and get the 340,000 students in CPS back into the classroom. [25]
When SHIELD Illinois consolidated its labs into two University-owned and operated facilities to optimize logistics during the 2021-2022 school year. The Incubator Lab Facility on the University of Illinois Chicago (UIC) campus, the building where SHIELD Illinois's NextGen sequencing and innovation lab was located, was not originally built to meet the criteria of a CLIA-certified clinical diagnostics lab. So, the program decided to invest in upgrading the facility to bring it up to modern standards. According to Len Musielak, SHIELD Illinois Senior Director of Operations, SHIELD wanted to not only upgrade the building for its purposes but also add in ways that would provide a benefit to other tenants now and far into the future. The project included $2.2 million in upgrades and had a six-week deadline to complete the most difficult tasks and make the lab operational.
Facility upgrades included:
The new lab was completed on August 1 and became operational on August 24. [13]
On Friday, July 21, 2023, Illinois Governor JB Pritzker and the Illinois Department of Public Health announced they were partnering with SHIELD Illinois to distribute air purifiers to licensed Illinois Day Care outside of the city of Chicago. The purifiers were purchased with $10 million dollars of federal funds through the CDC's Epidemiology and Laboratory Capacity for Prevention and Control (ELC) Reopening Schools Program. SHIELD Illinois will use the extensive logistics capabilities developed serving over 2,300 locations during the pandemic to distribute the filters across the state. [26]
The work of SHIELD Illinois will continue through the Clinical Laboratory Development Program powered by SHIELD Illinois ("CLDP"). Utilizing the state-of-the-art laboratory renovated by SHIELD Illinois at the University of Illinois Chicago, CLDP will address the critical shortage of qualified clinical laboratory personnel in Illinois. The goal of the program is to develop the next generation of laboratory technicians and scientists through hands-on training and work experience. [27]
Upon the conclusion of the SHIELD Illinois testing program, laboratory equipment and other hard assets were offered to public entities throughout the State of Illinois at no cost with the understanding that, should another pandemic occur, the equipment would be used however necessary to continue the mission of SHIELD Illinois to keep Illinois open.
In March 2023, SHIELD Illinois hosted a COVID-19 research symposium to spotlight the vital role of research in confronting future public health emergencies. In addition to seminars and speakers, researchers had the opportunity to apply for funding from SHIELD Illinois for projects related to SARS-CoV-2 and COVID-19. [28]
The University of Illinois System is a system of public universities in the U.S. state of Illinois consisting of three universities: Chicago, Springfield, and Urbana-Champaign. Across its three universities, the University of Illinois System enrolls more than 94,000 students. It had an operating budget of $7.18 billion in 2021.
The University of Illinois Chicago (UIC) is a public research university in Chicago, Illinois, United States. Its campus is in the Near West Side community area, adjacent to the Chicago Loop. The second campus established under the University of Illinois system, UIC is also the largest university in the Chicago metropolitan area, having more than 33,000 students enrolled in 16 colleges. It is classified among "R1: Doctoral Universities – Very high research activity."
The University of Illinois Urbana-Champaign is a public land-grant research university in Champaign, Illinois, and Urbana, Illinois. It is the flagship institution of the University of Illinois system and was founded in 1867. With over 53,000 students, the University of Illinois is one of the largest public universities by enrollment in the United States.
Chicago Public Schools (CPS), officially classified as City of Chicago School District #299 for funding and districting reasons, in Chicago, Illinois, is the fourth-largest school district in the United States, after New York, Los Angeles, and Miami-Dade County. For the 2020–21 school year, CPS reported overseeing 638 schools, including 476 elementary schools and 162 high schools; of which 513 were district-run, 115 were charter schools, 9 were contract schools and 1 was a SAFE school. The district serves 340,658 students. Chicago Public School students attend a particular school based on their area of residence, except for charter, magnet, and selective enrollment schools.
The University of Illinois College of Medicine offers a four-year program leading to the MD degree at four different sites in Illinois: Chicago, Peoria, Rockford, and formerly Urbana–Champaign. The Urbana–Champaign site stopped accepting new students after Fall 2016 to make room for the newly established Carle Illinois College of Medicine.
A lateral flow test (LFT), is an assay also known as a lateral flow device (LFD), lateral flow immunochromatographic assay, or rapid test. It is a simple device intended to detect the presence of a target substance in a liquid sample without the need for specialized and costly equipment. LFTs are widely used in medical diagnostics in the home, at the point of care, and in the laboratory. For instance, the home pregnancy test is an LFT that detects a specific hormone. These tests are simple and economical and generally show results in around five to thirty minutes. Many lab-based applications increase the sensitivity of simple LFTs by employing additional dedicated equipment. Because the target substance is often a biological antigen, many lateral flow tests are rapid antigen tests.
The Nathan M. Newmark Civil Engineering Laboratory, or Newmark Lab, located at 205 N. Mathews Avenue in Urbana, Illinois on the campus of the University of Illinois at Urbana–Champaign, houses the university's Department of Civil and Environmental Engineering. The Lab was built in 1967, and has been modified and updated a number of times since then. The facility was named after professor and department head Nathan M. Newmark after his death.
The Gies College of Business Instructional Facility (BIF) is a state-of-the-art business facility designed by Pelli Clarke Pelli Architects located on the Champaign campus at the University of Illinois Urbana–Champaign (UIUC).
The University of Illinois Laboratory High School, also known as Uni High or just Uni, was established in 1921 and is a laboratory school located on the engineering section of the University of Illinois campus in Urbana, Illinois. Its enrolls about 300 students, spanning five years. The school's alumni include three Nobel laureates and a Pulitzer Prize winner. In 2022, Uni High was named as a top-15 public school in Illinois by Niche and the following year rose to a top-15 public school in the nation. In 2006 and 2008, it was recognized as a "public elite" school by Newsweek because of its students' high scores on the SAT. Before the change in the SAT's format in 2016, the average SAT score was 2045, and now varies from 1400 to 1600. As of 2019, the average SAT was a 1470. The average ACT score is a 32.
The BC Centre for Disease Control is the public health arm for British Columbia's Provincial Health Services Authority.
Clear Labs, Inc. is a private genomics testing company headquartered in San Carlos, California, United States. It offers a fully automated, next-generation sequencing (NGS) platform for turnkey diagnostics, including SARS-CoV-2 genomic characterization and detection of foodborne pathogens such as listeria and salmonella. It can also verify a food's ingredients, its GMO status, or conduct other tests.
Color is a population health technology company which provides genetic tests and analysis directly to patients as well as through employers. The product focuses on genes that indicate risk for heart disease, cancer, and that affect medication response.
The Discovery Partners Institute (DPI), part of the University of Illinois System, conducts tech workforce development and applied research and development in Chicago. It is one of 15 Illinois Innovation Network (IIN) hubs, each of which is associated with one or more of the 12 four-year public universities in Illinois. DPI currently operates in office space at 200 South Wacker Drive, with plans to build a dedicated building within The 78, a neighborhood under development in Chicago's South Loop. DPI's stated goal is to attract individuals to Illinois tech careers and to facilitate corporate investment in Illinois, primarily through training and education and through applied research and development.
COVID-19 testing involves analyzing samples to assess the current or past presence of SARS-CoV-2. The two main types of tests detect either the presence of the virus or antibodies produced in response to infection. Molecular tests for viral presence through its molecular components are used to diagnose individual cases and to allow public health authorities to trace and contain outbreaks. Antibody tests instead show whether someone once had the disease. They are less useful for diagnosing current infections because antibodies may not develop for weeks after infection. It is used to assess disease prevalence, which aids the estimation of the infection fatality rate.
The ongoing COVID-19 pandemic began in the U.S. state of Illinois on January 24, 2020, when a woman in Chicago, who had just returned from the pandemic's place of origin in Wuhan, Hubei, China, tested positive for the virus. This was the second case of COVID-19 in the United States during the pandemic. The woman's husband was diagnosed with the disease a few days later, the first known case of human-to-human transmission in the United States. Community transmission was not suspected until March 8, when a case with no connection to other cases or recent travel was confirmed.
Curative Inc. is a health care startup company best known for scaling COVID-19 testing and COVID-19 vaccinations during the COVID-19 pandemic. In September 2022, Curative Inc. launched Curative Insurance Company, a new health insurance plan featuring no copays and no deductibles. Headquartered in Austin, Texas, with employees throughout the United States, the company was founded in January 2020 by Fred Turner, Isaac Turner, and Vlad Slepnev to create new diagnostic tests for sepsis and to improve outcomes for sepsis patients. In response to an urgent, unmet need for COVID-19 test development and production in the United States, Curative rapidly shifted focus in March 2020. The company's research team developed a new test for SARS-CoV-2 that utilized oral swabs rather than nasopharyngeal swabs. The Curative test was designed with a scalable process and opportunities to reduce healthcare worker exposure risk, and therefore the amount of personal protective equipment (PPE) used. An independent manufacturing and supply chain model was adopted to avoid competing with existing COVID-19 test companies for limited supplies and laboratory capacity.
The COVID-19 lab leak theory, or lab leak hypothesis, is the idea that SARS-CoV-2, the virus that caused the COVID-19 pandemic, came from a laboratory. This claim is highly controversial; most scientists believe the virus spilled into human populations through natural zoonosis, similar to the SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history. Available evidence suggests that the SARS-CoV-2 virus was originally harbored by bats, and spread to humans from infected wild animals, functioning as an intermediate host, at the Huanan Seafood Market in Wuhan, Hubei, China, in December 2019. Several candidate animal species have been identified as potential intermediate hosts. There is no evidence SARS-CoV-2 existed in any laboratory prior to the pandemic, or that any suspicious biosecurity incidents happened in any laboratory.
Janice K. Jackson is an American educator, educational administrator and former schools superintendent. Jackson served as the CEO of the Chicago Public Schools, the school district's superintendent position, from December 8, 2017, until June 30, 2021. Prior to her term as superintendent, Jackson was the chief education officer of the district.
COVID-19 rapid antigen tests or RATs, also frequently called COVID-19 lateral flow tests or LFTs, are rapid antigen tests used to detect SARS-CoV-2 infection (COVID-19). They are quick to implement with minimal training, cost a fraction of other forms of COVID-19 testing, and give users a result within 5–30 minutes. RATs have been used in several countries as part of mass testing or population-wide screening approaches. Many RATs can be used for self-testing, in which an individual "collects their own specimen… and interpret[s] their test result themselves".