The Smith-Kettlewell Eye Research Institute is a nonprofit research institute in San Francisco, California, with a focus on vision science and rehabilitation engineering. It was founded in 1959 by Arthur Jampolsky and Alan B. Scott, when some members of Stanford University's Ophthalmology Department elected to stay in San Francisco rather than move to Palo Alto. [1]
The Institute did early experiments in sensory substitution, especially the substitution of tactile information for visual information to help blind people navigate [2] and other methods to obtain accessible technology. [3] This research is often performed by scientists who are blind, such as Josh Miele. [4]
The institute's use of botulinum toxin in humans as a therapy to treat strabismus. This initial therapeutic use led to later cosmetic use in Botox. [5] Other impactful work involved Anthony Norcia's study of vision in infants [6] and Erich Sutter's invention of the multifocal electroretinogram and of the multifocal evoked potential. [7]
The Institute has originated various visual illusions, including Christopher Tyler's development of autostereograms, and Anthony Norcia's coffer illusion. [8] Also popular are Tyler's analysis of the position of eyes in paintings, [9] of Mona Lisa's smile [10] and of Leonardo da Vinci's possible eye condition. [11] [12]
Over the decades, the Institute has hosted generations of vision scientists, including
Persistence of vision is the optical illusion that occurs when the visual perception of an object does not cease for some time after the rays of light proceeding from it have ceased to enter the eye. The illusion has also been described as "retinal persistence", "persistence of impressions", simply "persistence" and other variations. A very commonly given example of the phenomenon is the apparent fiery trail of a glowing coal or burning stick while it is whirled around in the dark.
The retina is the innermost, light-sensitive layer of tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which then processes that image within the retina and sends nerve impulses along the optic nerve to the visual cortex to create visual perception. The retina serves a function which is in many ways analogous to that of the film or image sensor in a camera.
Floaters or eye floaters are sometimes visible deposits within the eye's vitreous humour, which is normally transparent, or between the vitreous and retina. They can become particularly noticeable when looking at a blank surface or an open monochromatic space, such as blue sky. Each floater can be measured by its size, shape, consistency, refractive index, and motility. They are also called muscae volitantes, or mouches volantes. The vitreous usually starts out transparent, but imperfections may gradually develop as one ages. The common type of floater, present in most people's eyes, is due to these degenerative changes of the vitreous. The perception of floaters, which may be annoying or problematic to some people, is known as myodesopsia, or, less commonly, as myodaeopsia, myiodeopsia, or myiodesopsia. It is not often treated, except in severe cases, where vitrectomy (surgery), laser vitreolysis, and medication may be effective.
Retinitis pigmentosa (RP) is a genetic disorder of the eyes that causes loss of vision. Symptoms include trouble seeing at night and decreasing peripheral vision. As peripheral vision worsens, people may experience "tunnel vision". Complete blindness is uncommon. Onset of symptoms is generally gradual and often begins in childhood.
Presbyopia is physiological insufficiency of accommodation associated with the aging of the eye that results in progressively worsening ability to focus clearly on close objects. Also known as age-related farsightedness, it affects many adults over the age of 40. A common sign of presbyopia is difficulty reading small print which results in having to hold reading material farther away. Other symptoms associated can be headaches and eyestrain. Different people will have different degrees of problems. Other types of refractive errors may exist at the same time as presbyopia. This condition is similar to hypermetropia or far-sightedness which starts in childhood and exhibits similar symptoms of blur in the vision for close objects.
An Intraocular lens (IOL) is a lens implanted in the eye usually as part of a treatment for cataracts or for correcting other vision problems such as short sightedness and long sightedness; a form of refractive surgery. If the natural lens is left in the eye, the IOL is known as phakic, otherwise it is a pseudophakic lens. Both kinds of IOLs are designed to provide the same light-focusing function as the natural crystalline lens. This can be an alternative to LASIK, but LASIK is not an alternative to an IOL for treatment of cataracts.
The Moon illusion is an optical illusion which causes the Moon to appear larger near the horizon than it does higher up in the sky. It has been known since ancient times and recorded by various cultures. The explanation of this illusion is still debated.
Christopher William Tyler is a neuroscientist, creator of the autostereogram, and is the Head of the Brain Imaging Center at the Smith-Kettlewell Eye Research Institute He also holds a professorship at City University of London.
The Ponzo illusion is a geometrical-optical illusion that takes its name from the Italian psychologist Mario Ponzo (1882–1960). Ponzo never claimed to have discovered it, and it is indeed present in earlier work. Much confusion is present about this including many references to a paper that Ponzo published in 1911 on the Aristotle illusion. This is a tactile effect and it has nothing at all to do with what we now call the Ponzo illusion. The illusion can be demonstrated by drawing two identical lines across a pair of converging lines, similar to railway tracks, but the effect works also at different orientations.
The Lions Eye Institute (LEI) is an Australian medical research institute affiliated with the University of Western Australia. It was established in 1983 with support of the Lions Clubs of Western Australia and headquartered in the Perth suburb of Nedlands, Western Australia. The LEI is a not-for-profit centre of excellence that combines an ophthalmic clinic with scientific discovery developing techniques for the prevention of blindness and the reduction of pain from blinding eye conditions.
Multifocal techniques are used in electroretinogram and visual evoked potential recordings to separate the responses originating from the stimulation of different locations in the visual field.
In human visual perception, the visual angle, denoted θ, subtended by a viewed object sometimes looks larger or smaller than its actual value. One approach to this phenomenon posits a subjective correlate to the visual angle: the perceived visual angle or perceived angular size. An optical illusion where the physical and subjective angles differ is then called a visual angle illusion or angular size illusion.
Many types of sense loss occur due to a dysfunctional sensation process, whether it be ineffective receptors, nerve damage, or cerebral impairment. Unlike agnosia, these impairments are due to damages prior to the perception process.
The Vision Institute is a research center in the Quinze-Vingts National Eye Hospital in Paris, France. It is one of several such centers in Europe on eye diseases.
Wolfgang Fink is a German-American theoretical physicist. He is currently an associate professor and the inaugural Maria & Edward Keonjian Endowed Chair of Microelectronics at the University of Arizona. Fink has joint appointments in the Departments of Electrical & Computer Engineering, Biomedical Engineering, Systems & Industrial Engineering, Aerospace & Mechanical Engineering, and Ophthalmology & Vision Science at the University of Arizona. He is the current Vice President of the Prognostics and Health Management (PHM) Society.
Alan Brown Scott was an American ophthalmologist specializing in eye muscles and their disorders, such as strabismus. He is best known for his work in developing and manufacturing the drug that became known as Botox, research described as "groundbreaking" by the ASCRS.
Zhuo-Hua Pan is a Chinese-American neuroscientist, known for his foundational contributions to optogenetics. He is the Edward T. and Ellen K. Dryer Endowed Professor of Ophthalmology at Wayne State University, and Scientific Director of the Ligon Research Center of Vision at the university's Kresge Eye Institute.
Occult macular dystrophy (OMD) is a rare inherited degradation of the retina, characterized by progressive loss of function in the most sensitive part of the central retina (macula), the location of the highest concentration of light-sensitive cells (photoreceptors) but presenting no visible abnormality. "Occult" refers to the degradation in the fundus being difficult to discern. The disorder is called "dystrophy" instead of "degradation" to distinguish its genetic origin from other causes, such as age. OMD was first reported by Y. Miyake et al. in 1989.
Visual impairment in art is a limited topic covered by research, with its focus being on how visually impaired people are represented in artwork throughout history. This is commonly portrayed through the inclusion of objects such as canes and dogs to symbolize blindness, which is the most frequently depicted visual impairment in art. Many notable figures in art history, such as Leonardo da Vinci, Claude Monet, and Georgia O'Keeffe, were visually impaired, or theorized to be so.
Joshua A. Miele is an American research scientist who specializes in accessible technology design. Miele conducted research on tactile graphics and auditory displays at the Smith-Kettlewell Eye Research Institute in California for fifteen years. In 2019, he joined Amazon Lab126, a subsidiary of Amazon that works on hardware products, where he is Principal Accessibility Researcher. He has been blind since early childhood.
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