Stephanie J. Murphy | |
|---|---|
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| Alma mater | University of Pennsylvania |
| Scientific career | |
| Institutions | Johns Hopkins University Oregon Health & Science University Office of Research Infrastructure Programs |
Stephanie J. Murphy is an American veterinary scientist. She is the director of the Division of Comparative Medicine (DCM) in the Office of Research Infrastructure Programs at the National Institutes of Health. Murphy was previously a faculty member at the Oregon Health & Science University.
Murphy received her V.M.D. and Ph.D. from the University of Pennsylvania. She completed a postdoctoral fellowship in the department of comparative medicine at Johns Hopkins University and is a diplomate of the American College of Laboratory Animal Medicine. [1]
Murphy joined the department of anesthesiology & critical care medicine at Johns Hopkins as an assistant professor. In 2003, she joined the research faculty at Oregon Health & Science University (OHSU) as a professor of anesthesiology & perioperative medicine. In 2014, Murphy was named director, Division of Comparative Medicine (DCM) in the Office of Research Infrastructure Programs. [1] In DCM, she oversees the human tissue and organ research resource and is the primary contact for R24 applications. Her expertise includes neuroscience and comparative medicine. [2]
Murphy has published articles, reviews and book chapters related to her research and clinical interests. She has secured NIH and other funding for the past 17 years to support her research on sex differences and sex steroids in stroke. [1]
Estrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. Another estrogen called estetrol (E4) is produced only during pregnancy.
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the major progestogen in the body. Progesterone has a variety of important functions in the body. It is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.
Hormone therapy or hormonal therapy is the use of hormones in medical treatment. Treatment with hormone antagonists may also be referred to as hormonal therapy or antihormone therapy. The most general classes of hormone therapy are oncologic hormone therapy, hormone replacement therapy, androgen replacement therapy (ART), oral contraceptive pills, and transgender hormone therapy.
The National Eye Institute (NEI) is part of the U.S. National Institutes of Health (NIH), an agency of the U.S. Department of Health and Human Services. The mission of NEI is "to eliminate vision loss and improve quality of life through vision research." NEI consists of two major branches for research: an extramural branch that funds studies outside NIH and an intramural branch that funds research on the NIH campus in Bethesda, Maryland. Most of the NEI budget funds extramural research.
Elizabeth Gould is an American neuroscientist and the Dorman T. Warren Professor of Psychology at Princeton University. She was an early investigator of adult neurogenesis in the hippocampus, a research area that continues to be controversial. In November 2002, Discover magazine listed her as one of the 50 most important women scientists.
Louise McCullough is an American neurologsit who is the Prof. Roy M. & Phyllis Gough Huffington Distinguished Chair of Neurology and is actively engaged in stroke research at the University of Texas Health Science Center in Houston, Texas. She provides neurological care at Memorial Hermann Hospital, which has a state-of-the-art stroke center and is co-director of the Mischer Neuroscience Institute.
G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene. GPER binds to and is activated by the female sex hormone estradiol and is responsible for some of the rapid effects that estradiol has on cells.
Emery Neal Brown is an American statistician, neuroscientist, and anesthesiologist. He is the Warren M. Zapol Professor of Anesthesia at Harvard Medical School and at Massachusetts General Hospital (MGH), and a practicing anesthesiologist at MGH. At MIT he is the Edward Hood Taplin Professor of Medical Engineering and professor of computational neuroscience, the associate director of the Institute for Medical Engineering and Science, and the Director of the Harvard–MIT Program in Health Sciences and Technology.
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. Effects of menopause can include symptoms such as hot flashes, accelerated skin aging, vaginal dryness, decreased muscle mass, and complications such as osteoporosis, sexual dysfunction, and vaginal atrophy. They are mostly caused by low levels of female sex hormones that occur during menopause.
Avindra "Avi" Nath, is a physician-scientist who specializes in neuroimmunology. Nath is a senior investigator, and intramural clinical director of the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH) in the United States. At NINDS, Nath also leads the Section of Infections of the Nervous System and plans to institute a translational research center. He previously served in several research and administrative positions at the Johns Hopkins Hospital and the Johns Hopkins University School of Medicine.
Clinical neuroscience is a branch of neuroscience that focuses on the scientific study of fundamental mechanisms that underlie diseases and disorders of the brain and central nervous system. It seeks to develop new ways of conceptualizing and diagnosing such disorders and ultimately of developing novel treatments.
Yasmin Hurd is the Ward-Coleman Chair of Translational Neuroscience and the Director of the Addiction Institute at Mount Sinai. Hurd holds appointments as faculty of Neuroscience, Psychiatry, Pharmacology and Systems Therapeutics at the Icahn School of Medicine at Mount Sinai in New York City and is globally recognized for her translational research on the underlying neurobiology of substance use disorders and comorbid psychiatric disorders. Hurd's research on the transgenerational effects of early cannabis exposure on the developing brain and behavior and on the therapeutic properties of cannabidiol has garnered substantial media attention. In 2017, Dr. Hurd was elected to the National Academy of Medicine and, in 2022, Dr. Hurd was elected to the National Academy of Sciences (NAS).
Elaine Ann Ostrander is an American geneticist at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in Bethesda, Maryland. She holds a number of professional academic appointments, currently serving as Distinguished and Senior Investigator and head of the NHGRI Section of Comparative Genomics; and Chief of the Cancer Genetics and Comparative Genomics Branch. She is known for her research on prostate cancer susceptibility in humans and for conducting genetic investigations with the Canis familiaris —the domestic dog— model, which she has used to study disease susceptibility and frequency and other aspects of natural variation across mammals. In 2007, her laboratory showed that much of the variation in body size of domestic dogs is due to sequence changes in a single gene encoding a growth-promoting protein.
Catherine S. Woolley is an American neuroendocrinologist. Woolley holds the William Deering Chair in Biological Sciences in the Department of Neurobiology, Weinberg College of Arts & Sciences, at Northwestern University. She is also a member of the Women's Health Research Institute in the Feinberg School of Medicine at Northwestern University.
Beth Darnall is American scientist, pain psychologist, author, and Associate Professor of Anesthesiology, Perioperative and Pain Medicine at the Stanford University School of Medicine where she directs the Stanford Pain Relief Innovations Lab. From 2005 to 2012, Darnall was an assistant professor and associate professor at Oregon Health & Science University.
Cyma Kathryn Van Petten is an American cognitive neuroscientist known for electrophysiological studies of language, memory, and cognition. She is Professor of Psychology at the State University of New York at Binghamton where she directs the Event-Related Potential Lab. Van Petten was recipient of the Early Career Award from the Society for Psychophysiological Research in 1994.
Franziska B. Grieder is a Swiss-American veterinary scientist. She is the director of the Office of Research Infrastructure Programs at the National Institutes of Health. Grieder was a faculty member and researcher at the Uniformed Services University of the Health Sciences.
Amanda Brown is an American immunologist and microbiologist as well as an associate professor of neurology and neuroscience at Johns Hopkins University School of Medicine in Baltimore, Maryland. Brown is notable for cloning one of the first recombinant HIV viruses and developing a novel method to visualize HIV infected cells using GFP fluorescence.
Glenda Marlene MacQueen was a Canadian medical researcher and medical college professor and administrator. She was vice-dean of the Cumming School of Medicine at the University of Calgary from 2012 to 2019.
Sex as a biological variable (SABV) is a research policy recognizing sex as an important variable to consider when designing studies and assessing results. Research including SABV has strengthened the rigor and reproducibility of findings. Public research institutions including the European Commission, Canadian Institutes of Health Research, and the U.S. National Institutes of Health have instituted SABV policies. Editorial policies were established by various scientific journals recognizing the importance and requiring research to consider SABV.
This article incorporates public domain material from websites or documents of the National Institutes of Health.