Stephen Friend

Stephen Friend at NightScience 2013 in Paris

Stephen H. Friend is co-founder and director of Sage Bionetworks. ^{[1] [2] [3]}

Formerly Senior Vice-president at Merck & Co. Friend co-founded Rosetta Inpharmatics with Leland H. Hartwell and Leroy Hood in 1996. ^[4] Much of his research has focused on cancer. ^[5]

Friend has also held faculty positions at Harvard Medical School and Massachusetts General Hospital. He received his Bachelor of Arts in philosophy, his Ph.D. in biochemistry and his M.D. from Indiana University in 1981. ^{[2] [6]}

In 2008, Friend co-founded and led the nonprofit Sage Bionetworks to change how researchers work together. The aim of the nonprofit was to change the way drug discovery is done to improve patient wait times. ^[7]

Friend worked at Apple from 2016 to 2017 on their health team, under COO Jeff Williams. ^{[8] [9]}

Recognition

Friend was named an Ashoka Fellow by Ashoka: Innovators for the Public in 2011. ^[10]

Selected bibliography

• Bartz, S. R.; Zhang, Z; Burchard, J; Imakura, M; Martin, M; Palmieri, A; Needham, R; Guo, J; Gordon, M; Chung, N; Warrener, P; Jackson, A. L.; Carleton, M; Oatley, M; Locco, L; Santini, F; Smith, T; Kunapuli, P; Ferrer, M; Strulovici, B; Friend, S. H.; Linsley, P. S. (2006). "Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions". Molecular and Cellular Biology. 26 (24): 9377–86. doi:10.1128/MCB.01229-06. PMC   1698535 . PMID   17000754.
• Radich, J. P.; Dai, H; Mao, M; Oehler, V; Schelter, J; Druker, B; Sawyers, C; Shah, N; Stock, W; Willman, C. L.; Friend, S; Linsley, P. S. (2006). "Gene expression changes associated with progression and response in chronic myeloid leukemia". Proceedings of the National Academy of Sciences. 103 (8): 2794–9. Bibcode:2006PNAS..103.2794R. doi: 10.1073/pnas.0510423103 . PMC   1413797 . PMID   16477019.
• Dai, H; Van't Veer, L; Lamb, J; He, Y. D.; Mao, M; Fine, B. M.; Bernards, R; Van De Vijver, M; Deutsch, P; Sachs, A; Stoughton, R; Friend, S (2005). "A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients". Cancer Research. 65 (10): 4059–66. doi: 10.1158/0008-5472.CAN-04-3953 . PMID   15899795.
• Lampe, J. W.; Stepaniants, S. B.; Mao, M; Radich, J. P.; Dai, H; Linsley, P. S.; Friend, S. H.; Potter, J. D. (2004). "Signatures of environmental exposures using peripheral leukocyte gene expression: Tobacco smoke". Cancer Epidemiology, Biomarkers & Prevention. 13 (3): 445–53. doi: 10.1158/1055-9965.445.13.3 . PMID   15006922. S2CID   7624677.
• Van 't Veer, L. J.; Dai, H; Van De Vijver, M. J.; He, Y. D.; Hart, A. A.; Bernards, R; Friend, S. H. (2003). "Expression profiling predicts outcome in breast cancer". Breast Cancer Research. 5 (1): 57–8. doi: 10.1186/bcr562 . PMC   154139 . PMID   12559048.
• Van De Vijver, M. J.; He, Y. D.; Van't Veer, L. J.; Dai, H; Hart, A. A.; Voskuil, D. W.; Schreiber, G. J.; Peterse, J. L.; Roberts, C; Marton, M. J.; Parrish, M; Atsma, D; Witteveen, A; Glas, A; Delahaye, L; Van Der Velde, T; Bartelink, H; Rodenhuis, S; Rutgers, E. T.; Friend, S. H.; Bernards, R (2002). "A gene-expression signature as a predictor of survival in breast cancer". New England Journal of Medicine. 347 (25): 1999–2009. doi:10.1056/NEJMoa021967. hdl: 1874/15577 . PMID   12490681.
• Lamb, J. R.; Zhang, C; Xie, T; Wang, K; Zhang, B; Hao, K; Chudin, E; Fraser, H. B.; Millstein, J; Ferguson, M; Suver, C; Ivanovska, I; Scott, M; Philippar, U; Bansal, D; Zhang, Z; Burchard, J; Smith, R; Greenawalt, D; Cleary, M; Derry, J; Loboda, A; Watters, J; Poon, R. T.; Fan, S. T.; Yeung, C; Lee, N. P.; Guinney, J; Molony, C; et al. (2011). "Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting". PLOS ONE. 6 (7): e20090. Bibcode:2011PLoSO...620090L. doi: 10.1371/journal.pone.0020090 . PMC   3130029 . PMID   21750698.
• Mihich, E; Feunteun, J; Friend, S (2002). "Thirteenth annual pezcoller symposium: Focusing analytical tools on complexity in cancer". Cancer Research. 62 (13): 3883–7. PMID   12097304.

References

1. Kaiser, J. (2012). "The Visionary". Science. 335 (6069): 651–3. doi:10.1126/science.335.6069.651. PMID   22323794.
2. "Sage Bionetworks Seattle | Directors". Archived from the original on 2012-01-27. Retrieved 2012-02-11.
3. "Stephen Friend". Nature Reviews Drug Discovery. 7 (2): 114. 2008. doi: 10.1038/nrd2509 .
4. Nelson, Bryn; Schadt, E (2009). "Something wiki this way comes". Nature. 458 (7234): 13. doi: 10.1038/458013a . PMID   19262635.
5. Kaiser, J. (2012). "The Visionary". Science. 335 (6069): 651–3. doi:10.1126/science.335.6069.651. PMID   22323794.
6. "Dr. Stephen Friend, Pediatrics". WebMD. Retrieved 2025-02-28.
7. "Seattle's Sage Bionetworks seeks a drug-discovery revolution". The Seattle Times. 2012-02-11. Retrieved 2025-02-28.
8. Farr, Christina (2018-02-06). "Stephen Friend, a well-known health researcher, is out at Apple after less than two years". CNBC. Retrieved 2025-02-28.
9. Farr, Christina (2019-08-20). "Apple health team faces departures as tensions rise over differing visions for the future". CNBC. Retrieved 2025-02-28.
10. http://sagebase.org/info/NewsInfoDownloads/SageAshokaRelease6APR2011.pdf%5B‍%5D

External links

• TED talk with Stephen Friend