Clozapine is the first atypical antipsychotic medication to have been discovered. It is usually used in tablet or liquid form for people diagnosed with schizophrenia who have had an inadequate response to other antipsychotics or who have been unable to tolerate other drugs due to extrapyramidal side effects. It is also used for the treatment of psychosis in Parkinson's disease. In the US it is also licensed for use in patients with recurrent suicidal behaviour associated with schizophrenia or schizoaffective disorder. It is regarded as the gold-standard treatment when other medication has been insufficiently effective and its use is recommended by multiple international treatment guidelines. Compared to other antipsychotic drug treatments, initiating and maintaining clozapine is complex, expensive and time-consuming. The role of clozapine in treatment-resistant schizophrenia was established by the Clozaril Collaborative Study Group Study #30 in which clozapine showed marked benefits compared to chlorpromazine in a group of patients with protracted psychosis and who had already shown an inadequate response to other antipsychotics. There are a range of different adverse effects and compulsory blood monitoring is required in most developed countries. Whilst there are significant side effects, clozapine remains the most effective treatment when one or more other antipsychotics have had an inadequate response, and clozapine use is associated with multiple improved outcomes including all cause mortality, suicide and reduced hospitalisation. In a network comparative meta-analysis of 15 antipsychotic drugs, clozapine was significantly more effective than all other drugs. Surveys of patient satisfaction show preference over other antipsychotics.
Loxapine, sold under the brand names Loxitane and Adasuve among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia. The medicine is a member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as a typical antipsychotic, behaves as an atypical antipsychotic.
Child psychopathology refers to the scientific study of mental disorders in children and adolescents. Oppositional defiant disorder, attention-deficit hyperactivity disorder, and autism spectrum disorder are examples of psychopathology that are typically first diagnosed during childhood. Mental health providers who work with children and adolescents are informed by research in developmental psychology, clinical child psychology, and family systems. Lists of child and adult mental disorders can be found in the International Statistical Classification of Diseases and Related Health Problems, 10th Edition (ICD-10), published by the World Health Organization (WHO) and in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), published by the American Psychiatric Association (APA). In addition, the Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood is used in assessing mental health and developmental disorders in children up to age five.
Elissa Panush Benedek is an American psychiatrist specializing in child and adolescent psychiatry and forensic psychiatry. She is an adjunct clinical professor of psychiatry at the University of Michigan Medical Center. She served as director of research and training at the Center for Forensic Psychiatry in Ann Arbor for 25 years and was president of the American Psychiatric Association from 1990 to 1991. She is regarded as an expert on child abuse and trauma, and has testified in high-profile court cases. She also focuses on ethics, psychiatric aspects of disasters and terrorism, and domestic violence. In addition to her own books, book chapters, and articles, she has collaborated with her husband, attorney Richard S. Benedek, on studies of divorce, child custody, and child abuse.
Suicidal ideation, or suicidal thoughts, is the thought process of having ideas, or ruminations about the possibility of committing suicide. It is not a diagnosis but is a symptom of some mental disorders, use of certain psychoactive drugs, and can also occur in response to adverse life events without the presence of a mental disorder.
Gender is correlated with the prevalence of certain mental disorders, including depression, anxiety and somatic complaints. For example, women are more likely to be diagnosed with major depression, while men are more likely to be diagnosed with substance abuse and antisocial personality disorder. There are no marked gender differences in the diagnosis rates of disorders like schizophrenia and bipolar disorder. Men are at risk to suffer from post-traumatic stress disorder (PTSD) due to past violent experiences such as accidents, wars and witnessing death, and women are diagnosed with PTSD at higher rates due to experiences with sexual assault, rape and child sexual abuse. Nonbinary or genderqueer identification describes people who do not identify as either male or female. People who identify as nonbinary or gender queer show increased risk for depression, anxiety and post-traumatic stress disorder. People who identify as transgender demonstrate increased risk for depression, anxiety, and post-traumatic stress disorder.
Child and adolescent psychiatry is a branch of psychiatry that focuses on the diagnosis, treatment, and prevention of mental disorders in children, adolescents, and their families. It investigates the biopsychosocial factors that influence the development and course of psychiatric disorders and treatment responses to various interventions. Child and adolescent psychiatrists primarily use psychotherapy and/or medication to treat mental disorders in the pediatric population.
Youth suicide is when a young person, generally categorized as someone below the legal age of majority, deliberately ends their own life. Rates of youth suicide and attempted youth suicide in Western societies and other countries are high. Youth suicide attempts are more common among girls, but adolescent males are the ones who usually carry out suicide. Suicide rates in youths have nearly tripled between the 1960s and 1980s. For example, in Australia suicide is second only to motor vehicle accidents as its leading cause of death for people aged 15 to 25.
David Murray Fergusson was a New Zealand psychologist. He was a professor of psychological medicine at the University of Otago, Christchurch, from 1999 until 2015. He is notable for work on the Christchurch Health and Development Study and for his research on abortion and mental health.
Felicity Anne Goodyear-Smith is a medical doctor, academic, and public health advocate from New Zealand. She is Academic Head of Department & Goodfellow Postgraduate Chair of General Practice & Primary Health Care in the Faculty of Medical and Health Science at the University of Auckland, New Zealand.
William H. Reid is an American forensic psychiatrist based in Texas. Reid has given expert witness testimony on several high-profile legal cases and has contributed to various academic publications.
David Taylor FFRPS FRPharmS is a British professor. He is the head of the Pharmaceutical Sciences Clinical Academic Group within King's Health Partners. Taylor has been lead author and editor of the Maudsley Prescribing Guidelines in Psychiatry since 1994. In 2014, Taylor was named as one of the top 100 clinical leaders in the UK National Health Service.
Suzanne Georgina Pitama is a New Zealand academic, is Māori, of Ngāti Kahungunu and Ngāti Whare descent and as of 2020 is a full professor at the University of Otago in Christchurch, New Zealand.
Joanne Mary Baxter is a New Zealand Māori public health medicine physician and academic and affiliates with the iwi of Ngāi Tahu, Kāti Māmoe, Waitaha and Ngāti Apa ki te Rā Tō. She is a professor and director of Kōhatu, Centre for Hauora Māori, and co-director of the Māori Health Workforce Development Unit at the University of Otago. Baxter took up the position of dean of the Dunedin School of Medicine on 1 July 2022, and is the first Māori woman in the role.
Sarah E. RomansFRANZCP is a New Zealand academic psychiatrist and Emerita Professor at the University of Otago.
Lois J. Surgenor is a New Zealand clinical psychologist and academic. Her research focuses on eating disorders and traumatic brain injury. As of 2021 she is a full professor at the University of Otago.
Rachel Zajac is a New Zealand forensic psychologist and professor at the University of Otago in Dunedin.
Alan Ivan Green was an American psychiatrist. He was the Raymond Sobel Professor of Psychiatry at Geisel School of Medicine and longtime chairman of the school's psychiatry department.
Terryann Coralie Clark, known as TC, is a New Zealand Māori nursing academic, and as of 2023 is a full professor at the University of Auckland, specialising in Māori health, adolescent wellbeing and mental and sexual health.
Suzanne Marie Crengle is a New Zealand Māori academic, of Kāti Māmoe, Kāi Tahu and Waitaha descent and as of 2020 is a full professor at the University of Otago, specialising in public health medicine.
