The women's 400 metre individual medley event at the 2010 Asian Games took place on 14 November 2010 at Guangzhou Aoti Aquatics Centre.
Wang Shun is a Chinese competitive swimmer. A versatile medley swimmer, he became the first Asian male swimmer to win a gold medal at the men's 200m individual medley at the Olympic Games when he came in first at the 2020 Summer Olympics men's 200 metre individual medley. He is also the first swimmer from China to win a gold medal in an Olympic men's medley swimming event. He had earlier won a bronze medal in the same event at the 2016 Summer Olympics.
Ratapong "Nuk" Sirisanont is a Thai former swimmer, who specialized in breaststroke, but also competed in long-distance freestyle and individual medley. He is a four-time Olympian, a three-time Asian Games participant, and a seven-time SEA Games athlete (1991–2003). Regarded as Thailand's top swimmer, he has won a total of sixteen medals at the Southeast Asian Games since 1995, and six at the Asian Games, including two golds in the 200 and 400 m individual medley. At the 1996 Summer Olympics in Atlanta, Sirisanont became the first Thai swimmer to reach the final twice. Sirisanont is also one of three Southeast Asian swimmers, along with Malaysia's Alex Lim and Philippines' Miguel Molina, to train for the California Golden Bears in the United States, under head coach Nort Thornton.
Qin Haiyang is a Chinese swimmer who specializes in the breaststroke and individual medley. He is the current world record holder in the 200m breaststroke. At the 2023 World Aquatics Championships, Qin became the first swimmer in history to win all three breaststroke events at a single edition of the championships. Qin was also the former world junior record holder in the 200m breaststroke and 200m individual medley. In 2023, he was named as the most valuable player in the men's division, in the 2022 Asian Games in Hangzhou.
The mixed 4 × 100 metre medley relay event at the 2022 Asian Games took place on 27 September 2023 at the Hangzhou Olympic Sports Expo Center.
