Synbiotics

Last updated

Synbiotics refer to food ingredients or dietary supplements combining probiotics and prebiotics in a form of synergism, hence synbiotics. [1] The synbiotic concept was first introduced as "mixtures of probiotics and prebiotics that beneficially affect the host by improving the survival and implantation of live microbial dietary supplements in the gastrointestinal tract, by selectively stimulating the growth and/or by activating the metabolism of one or a limited number of health-promoting bacteria, thus improving host welfare". [2] As of 2018, the research on this concept is preliminary, with no high-quality evidence from clinical research that such benefits exist.

Synbiotics may be complementary synbiotics, where each component is independently chosen for its potential effect on host health, or synergistic synbiotics, where the prebiotic component is chosen to support the activity of the chosen probiotic. [3] Research is evaluating if synbiotics can be optimized, (known as 'optibiotics') [3] which are purported to enhance the growth and health benefits of existing probiotics. [4]

Probiotics are live bacteria which are intended to colonize the large intestine, although as of 2018, there is no evidence that adding dietary bacteria to healthy people has any added effect. [5] A prebiotic is a food or dietary supplement product that may induce the growth or activity of beneficial microorganisms. A prebiotic may be a fiber, but a fiber is not necessarily a prebiotic. [3] [6]

Using prebiotics and probiotics in combination may be described as synbiotic, but the United Nations Food & Agriculture Organization recommends that the term "synbiotic" be used only if the net health benefit is synergistic. [7] Synbiotic formulations in combination with pasteurized breast milk are under preliminary clinical research for their potential to ameliorate necrotizing enterocolitis in infants, although there was insufficient evidence to warrant recommending synbiotics for this use as of 2016. [8]

Examples

Related Research Articles

<i>Lactobacillus</i> Genus of bacteria

Lactobacillus is a genus of gram-positive, aerotolerant anaerobes or microaerophilic, rod-shaped, non-spore-forming bacteria. Until 2020, the genus Lactobacillus comprised over 260 phylogenetically, ecologically, and metabolically diverse species; a taxonomic revision of the genus assigned lactobacilli to 25 genera.

<span class="mw-page-title-main">Fructose malabsorption</span> Medical condition

Fructose malabsorption, formerly named dietary fructose intolerance (DFI), is a digestive disorder in which absorption of fructose is impaired by deficient fructose carriers in the small intestine's enterocytes. This results in an increased concentration of fructose. Intolerance to fructose was first identified and reported in 1956.

<span class="mw-page-title-main">Probiotic</span> Microorganisms said to provide health benefits when consumed

Probiotics are live microorganisms promoted with claims that they provide health benefits when consumed, generally by improving or restoring the gut microbiota. Probiotics are considered generally safe to consume, but may cause bacteria-host interactions and unwanted side effects in rare cases. There is some evidence that probiotics are beneficial for some conditions, but there is little evidence for many of the health benefits claimed for them.

Prebiotics are compounds in food that foster growth or activity of beneficial microorganisms such as bacteria and fungi. The most common environment considered is the gastrointestinal tract, where prebiotics can alter the composition of organisms in the gut microbiome.

<span class="mw-page-title-main">Gut microbiota</span> Community of microorganisms in the gut

Gut microbiota, gut microbiome, or gut flora, are the microorganisms, including bacteria, archaea, fungi, and viruses, that live in the digestive tracts of animals. The gastrointestinal metagenome is the aggregate of all the genomes of the gut microbiota. The gut is the main location of the human microbiome. The gut microbiota has broad impacts, including effects on colonization, resistance to pathogens, maintaining the intestinal epithelium, metabolizing dietary and pharmaceutical compounds, controlling immune function, and even behavior through the gut–brain axis.

<i>Bifidobacterium animalis</i> Species of bacterium

Bifidobacterium animalis is a gram-positive, anaerobic, rod-shaped bacterium of the Bifidobacterium genus which can be found in the large intestines of most mammals, including humans.

A bifidus factor is a compound that specifically enhances the growth of bifidobacteria in either a product or in the intestines of humans and/or animals. Several products have been marketed as bifidogenic factors, such as several prebiotics and methyl-N-acetyl D-glucosamine in human milk.

Natural growth promoters (NGPs) are feed additives for farm animals.

Limosilactobacillus reuteri is a lactic acid bacterium found in a variety of natural environments, including the gastrointestinal tract of humans and other animals. It does not appear to be pathogenic and may have health effects.

<span class="mw-page-title-main">Galactooligosaccharide</span> Class of prebiotics

Galactooligosaccharides (GOS), also known as oligogalactosyllactose, oligogalactose, oligolactose or transgalactooligosaccharides (TOS), belong to the group of prebiotics. Prebiotics are defined as non-digestible food ingredients that beneficially affect the host by stimulating the growth and/or activity of beneficial bacteria in the colon. GOS occurs in commercially available products such as food for both infants and adults.

<i>Bifidobacterium</i> Genus of bacteria

Bifidobacterium is a genus of gram-positive, nonmotile, often branched anaerobic bacteria. They are ubiquitous inhabitants of the gastrointestinal tract though strains have been isolated from the vagina and mouth of mammals, including humans. Bifidobacteria are one of the major genera of bacteria that make up the gastrointestinal tract microbiota in mammals. Some bifidobacteria are used as probiotics.

<span class="mw-page-title-main">Xylooligosaccharide</span> Polymer of the sugar xylose

Xylooligosaccharides (XOS) are polymers of the sugar xylose. They are produced from the xylan fraction in plant fiber. Their C5 structure is fundamentally different from other prebiotics, which are based upon C6 sugars. Xylooligosaccharides have been commercially available since the 1980s, originally produced by Suntory in Japan. They have more recently become more widely available commercially, as technologies have advanced and production costs have fallen. Some enzymes from yeast can exclusively convert xylan into only xylooligosaccharides-DP-3 to 7.

<i>Lacticaseibacillus paracasei</i> Species of bacterium

Lacticaseibacillus paracasei (commonly abbreviated as Lc. paracasei) is a gram-positive, homofermentative species of lactic acid bacteria that are commonly used in dairy product fermentation and as probiotic cultures. Lc. paracasei is a bacterium that operates by commensalism. It is commonly found in many human habitats such as human intestinal tracts and mouths as well as sewages, silages, and previously mentioned dairy products. The name includes morphology, a rod-shaped bacterium with a width of 2.0 to 4.0μm and length of 0.8 to 1.0μm.

Bacteriotherapy is the purposeful use of bacteria or their products in treating an illness. Forms of bacteriotherapy include the use of probiotics, microorganisms that provide health benefits when consumed; fecal matter transplants (FMT) /intestinal microbiota transplant (IMT), the transfer of gut microorganisms from the fecal matter of healthy donors to recipient patients to restore microbiota; or synbiotics which combine prebiotics, indigestible ingredients that promote growth of beneficial microorganisms, and probiotics. Through these methods, the gut microbiota, the community of 300-500 microorganism species that live in the digestive tract of animals aiding in digestion, energy storage, immune function and protection against pathogens, can be recolonized with favorable bacteria, which in turn has therapeutic effects.

<i>Bifidobacterium bifidum</i> Species of bacterium

Bifidobacterium bifidum is a bacterial species of the genus Bifidobacterium. B. bifidum is one of the most common probiotic bacteria that can be found in the body of mammals, including humans.

Bifidobacterium breve is a bacterial species of the genus Bifidobacterium which has probiotic properties. Bifidobacteria are a type of bacteria that live symbiotically in the intestines of humans. They have been used to treat a number of conditions including constipation, diarrhea, irritable bowel syndrome and even the cold and flu. Some of these uses have been backed up by scientific research, but others have not. B. breve is a gram positive, anaerobic, rod shaped organism that is non motile and forms branches with its neighbors.

Psychobiotics is a term used in preliminary research to refer to live bacteria that, when ingested in appropriate amounts, might confer a mental health benefit by affecting microbiota of the host organism. Whether bacteria might play a role in the gut-brain axis is under research. A 2020 literature review suggests that the consumption of psychobiotics could be considered as a viable option to restore mental health although lacking randomized controlled trials on clear mental health outcomes in humans.

<span class="mw-page-title-main">Human milk microbiome</span> Community of microorganisms in human milk

The human milk microbiota, also known as human milk probiotics (HMP), refers to the microbiota (community of microorganisms) residing in the human mammary glands and breast milk. Human breast milk has been traditionally assumed to be sterile, but more recently both microbial culture and culture-independent techniques have confirmed that human milk contains diverse communities of bacteria which are distinct from other microbial communities inhabiting the human body.

<span class="mw-page-title-main">Kestose</span> Sugar from fructooligosaccharide group

Kestose is a class of sugars that belongs to a group of fructooligosaccharides.

Bifidobacterium adolescentis is an anaerobic species of bacteria found in the gastrointestinal tracts of humans and other primates. It is one of the most abundant and prevalent Bifidobacterium species detected in human populations, especially in adults.

References

  1. Pandey KR, Naik SR, Vakil BV (2015). "Probiotics, prebiotics and synbiotics – a review". J Food Sci Technol. 52 (12): 7577–87. doi:10.1007/s13197-015-1921-1. PMC   4648921 . PMID   26604335.
  2. Gibson GR, Roberfroid MB (1995). "Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics". J. Nutr. 125 (6): 1401–12. doi:10.1093/jn/125.6.1401. PMID   7782892.
  3. 1 2 3 Rastall, RA. "Targeted Synbiotics to Manipulate the Microbiome for Health" (PDF). p. 10. Archived from the original (PDF) on 13 October 2017. Retrieved 2 October 2017.
  4. Kolida, S; Gibson, GR; Rastall, RA (20 June 2017). "Development of a Targeted Synergistic Synbiotic for Lactobacillus plantarum LPLDL" (PDF). Archived from the original (PDF) on 2 October 2017. Retrieved 2 October 2017.
  5. Rijkers GT, de Vos WM, Brummer RJ, Morelli L, Corthier G, Marteau P (2011). "Health benefits and health claims of probiotics: Bridging science and marketing". British Journal of Nutrition. 106 (9): 1291–96. doi: 10.1017/S000711451100287X . PMID   21861940.
  6. Ridgley, Mavis B. "What is the Difference Between Prebiotics and Probiotics?" . Retrieved 19 April 2016.
  7. Pineiro M, Asp NG, Reid G, Macfarlane S, Morelli L, Brunser O, Tuohy K (2008). "FAO Technical meeting on prebiotics". J Clin Gastroenterol. 42 Suppl 3 Pt 2: S156–59. doi:10.1097/MCG.0b013e31817f184e. PMID   18685504.
  8. Johnson-Henry, K. C; Abrahamsson, T. R; Wu, R. Y; Sherman, P. M (2016). "Probiotics, Prebiotics, and Synbiotics for the Prevention of Necrotizing Enterocolitis". Advances in Nutrition. 7 (5): 928–37. doi:10.3945/an.116.012237. PMC   5015037 . PMID   27633108.
  9. Thilakarathna, WPD Wass; Langille, Morgan GI; Rupasinghe, HP Vasantha (April 1, 2018). "Polyphenol-based prebiotics and synbiotics: potential for cancer chemoprevention". Current Opinion in Food Science. 20: 51–57. doi:10.1016/j.cofs.2018.02.011 via ScienceDirect.