Tablet hardness testing is a laboratory technique used by the pharmaceutical industry to determine the breaking point and structural integrity of a tablet and find out how it changes "under conditions of storage, transportation, packaging and handling before usage" [1] The breaking point of a tablet is based on its shape. [2] It is similar to friability testing, [1] but they are not the same thing.
Tablet hardness testers first appeared in the 1930s. [3] In the 1950s, the Strong-Cobb tester was introduced. It was patented by Robert Albrecht on July 21, 1953. [4] and used an air pump. The tablet breaking force was based on arbitrary units referred to as Strong-Cobbs. [3] The new one gave readings that were inconsistent to those given by the older testers. [3] Later, electro-mechanical testing machines were introduced. They often include mechanisms like motor drives, and the ability to send measurements to a computer or printer. [3]
There are 2 main processes to test tablet hardness: compression testing and 3 point bend testing. For compression testing, the analyst generally aligns the tablet in a repeatable way, [2] and the tablet is squeezed between a fixed and a moving jaw. The first machines continually applied force with a spring and screw thread until the tablet started to break. [3] When the tablet fractured, the hardness was read with a sliding scale. [3]
There are several devices used to perform this task:
The units of measurement of tablet hardness mostly follows standards used in materials testing – the International System of Units.
Measurement is the quantification of attributes of an object or event, which can be used to compare with other objects or events. In other words, measurement is a process of determining how large or small a physical quantity is as compared to a basic reference quantity of the same kind. The scope and application of measurement are dependent on the context and discipline. In natural sciences and engineering, measurements do not apply to nominal properties of objects or events, which is consistent with the guidelines of the International vocabulary of metrology published by the International Bureau of Weights and Measures. However, in other fields such as statistics as well as the social and behavioural sciences, measurements can have multiple levels, which would include nominal, ordinal, interval and ratio scales.
The International System of Units, known by the international abbreviation SI in all languages and sometimes pleonastically as the SI system, is the modern form of the metric system and based on the metre as the unit of length and either the kilogram as the unit of mass or the kilogram-force as the unit of force.</ref> and the world's most widely used system of measurement. Established and maintained by the General Conference on Weights and Measures (CGPM), it is the only system of measurement with an official status in nearly every country in the world, employed in science, technology, industry, and everyday commerce.
The tonne is a metric unit of mass equal to 1,000 kilograms. It is also referred to as a metric ton to distinguish it from the non-metric units of the short ton, and the long ton. It is equivalent to approximately 2,204.6 pounds, 1.102 short tons, and 0.984 long tons. The official SI unit is the megagram, a less common way to express the same mass.
In science and engineering, the weight of an object is the force acting on the object due to gravity.
The metric system is a system of measurement that succeeded the decimalised system based on the metre that had been introduced in France in the 1790s. The historical development of these systems culminated in the definition of the International System of Units (SI) in the mid-20th century, under the oversight of an international standards body. Adopting the metric system is known as metrication.
The newton is the unit of force in the International System of Units (SI). It is defined as 1 kg⋅m/s2, the force which gives a mass of 1 kilogram an acceleration of 1 metre per second per second. It is named after Isaac Newton in recognition of his work on classical mechanics, specifically Newton's second law of motion.
A tablet is a pharmaceutical oral dosage form or solid unit dosage form. Tablets may be defined as the solid unit dosage form of medicament or medicaments with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose.
The newton-metre is the unit of torque in the International System of Units (SI). One newton-metre is equal to the torque resulting from a force of one newton applied perpendicularly to the end of a moment arm that is one metre long. The nonstandard notation Nm occurs in some fields.
The Rockwell scale is a hardness scale based on indentation hardness of a material. The Rockwell test measures the depth of penetration of an indenter under a large load compared to the penetration made by a preload. There are different scales, denoted by a single letter, that use different loads or indenters. The result is a dimensionless number noted as HRA, HRB, HRC, etc., where the last letter is the respective Rockwell scale.
The kilogram-force, or kilopond, is a non-standard gravitational metric unit of force. It does not comply with the International System of Units (SI) and is deprecated for most uses. The kilogram-force is equal to the magnitude of the force exerted on one kilogram of mass in a 9.80665 m/s2 gravitational field. That is, it is the weight of a kilogram under standard gravity. Therefore, one kilogram-force is by definition equal to 9.80665 N. Similarly, a gram-force is 9.80665 mN, and a milligram-force is 9.80665 μN.
The Brinell scale characterizes the indentation hardness of materials through the scale of penetration of an indenter, loaded on a material test-piece. It is one of several definitions of hardness in materials science.
Timken OK Load is a standardized measurement that indicates the possible performance of extreme pressure (EP) additives in a lubricating grease or oil. The units of measurement are pounds-force or kilograms-force. This measurement is performed using a special test machine and standard block and ring test specimens.
The Vickers hardness test was developed in 1921 by Robert L. Smith and George E. Sandland at Vickers Ltd as an alternative to the Brinell method to measure the hardness of materials. The Vickers test is often easier to use than other hardness tests since the required calculations are independent of the size of the indenter, and the indenter can be used for all materials irrespective of hardness. The basic principle, as with all common measures of hardness, is to observe a material's ability to resist plastic deformation from a standard source. The Vickers test can be used for all metals and has one of the widest scales among hardness tests. The unit of hardness given by the test is known as the Vickers Pyramid Number (HV) or Diamond Pyramid Hardness (DPH). The hardness number can be converted into units of pascals, but should not be confused with pressure, which uses the same units. The hardness number is determined by the load over the surface area of the indentation and not the area normal to the force, and is therefore not pressure.
A kilogram-force per centimetre square (kgf/cm2), often just kilogram per square centimetre (kg/cm2), or kilopond per centimetre square is a deprecated unit of pressure using metric units. It is not a part of the International System of Units (SI), the modern metric system. 1 kgf/cm2 equals 98.0665 kPa (kilopascals). It is also known as a technical atmosphere.
In materials science, hardness is a measure of the resistance to localized plastic deformation induced by either mechanical indentation or abrasion. In general, different materials differ in their hardness; for example hard metals such as titanium and beryllium are harder than soft metals such as sodium and metallic tin, or wood and common plastics. Macroscopic hardness is generally characterized by strong intermolecular bonds, but the behavior of solid materials under force is complex; therefore, hardness can be measured in different ways, such as scratch hardness, indentation hardness, and rebound hardness.
The gravitational metric system is a non-standard system of units, which does not comply with the International System of Units (SI). It is built on the three base quantities length, time and force with base units metre, second and kilopond respectively. Internationally used abbreviations of the system are MKpS, MKfS or MKS . However, the abbreviation MKS is also used for the MKS system of units, which, like the SI, uses mass in kilogram as a base unit.
The Janka hardness test, created by Austrian-born American researcher Gabriel Janka (1864–1932), measures the resistance of a sample of wood to denting and wear. It measures the force required to embed an 11.28-millimeter-diameter steel ball halfway into a sample of wood. A common use of Janka hardness ratings is to determine whether a species is suitable for use as flooring. For hardwood flooring, the test usually requires a 50 mm × 150 mm sample with a thickness of at least 6–8 mm, and the most commonly used test is the ASTM D1037. When testing wood in lumber form, the Janka test is always carried out on wood from the tree trunk, and the standard sample is at 12% moisture content and clear of knots.
In common usage, the mass of an object is often referred to as its weight, though these are in fact different concepts and quantities. Nevertheless, one object will always weigh more than a second object, if the first object has greater mass, and the two objects are subject to the same gravity.
A unit of measurement is a definite magnitude of a quantity, defined and adopted by convention or by law, that is used as a standard for measurement of the same kind of quantity. Any other quantity of that kind can be expressed as a multiple of the unit of measurement.
A roll hardness tester is a device to measure the roll hardness, hardness profile and hardness variation of paper rolls.