Temelimab

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Temelimab
Monoclonal antibody
Type ?
Legal status
Legal status
  • Experimental
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Temelimab (also known as GNbAC1 [1] ) is an experimental monoclonal antibody drug for immune system conditions that neutralizes the human endogenous retrovirus envelope protein HERV-W. [2] [3] It has been studied for multiple sclerosis up to phase 2b, where it was found to be safe and to reduce brain lesions. [1] As of 2023, it is also being studied for cognitive impairment in long COVID. [4]

References

  1. 1 2 Irfan SA, Murtaza M, Ahmed A, Altaf H, Ali AA, Shabbir N, Baig MM (May 2022). "Promising role of temelimab in multiple sclerosis treatment". Multiple Sclerosis and Related Disorders. 61: 103743. doi:10.1016/j.msard.2022.103743. PMID   35344907. S2CID   247489555.
  2. ↑ Mouliou DS, Dardiotis E (August 2022). "Temelimab for MS and SARS-CoV-2: Could it be a double-edged blessing?". Multiple Sclerosis and Related Disorders. 64: 103938. doi:10.1016/j.msard.2022.103938. PMC   9169463 . PMID   35717898.
  3. ↑ Kornmann G, Curtin F (December 2020). "Temelimab, an IgG4 Anti-Human Endogenous Retrovirus Monoclonal Antibody: An Early Development Safety Review". Drug Safety. 43 (12): 1287–1296. doi:10.1007/s40264-020-00988-3. PMID   32794123. S2CID   221126453.
  4. ↑ Bonilla H, Peluso MJ, Rodgers K, Aberg JA, Patterson TF, Tamburro R, et al. (2023-03-09). "Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative". Frontiers in Immunology. 14: 1129459. doi: 10.3389/fimmu.2023.1129459 . PMC   10034329 . PMID   36969241.
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