State Route 8 is a 75.43-mile-long (121.39 km) north–south state highway in East and Middle Tennessee. It connects the cities of Chattanooga and McMinnville via Signal Mountain and Dunlap.
In Tennessee, U.S. Route 412 stretches for 181.93 miles (292.79 km) through the farmland of West Tennessee and the hills of Middle Tennessee, starting at the Missouri state line near Dyersburg and running to an interchange between I-65 and SR 99 in Columbia.
State Route 21 is a two lane highway that runs from the Mississippi River west of Tiptonville, Tennessee to the Kentucky state line north of Union City. This road provides access to Reelfoot Lake State Park.
State Route 63 is an east–west state highway in the northern portion of eastern Tennessee. It goes from U.S. Route 27 in Huntsville to SR 33 in Sneedville, running 102 miles (164 km).
State Route 92 is a state highway in East Tennessee with both four lane and two lane sections.
State Route 290 is a 19.7-mile-long (31.7 km) state highway in Jackson and Putnam counties in the U.S. state of Tennessee. It connects SR 53 northeast of Granville to SR 135 in Cookeville via SR 56 and Bloomington Springs.
State Route 296, also known as Taylor Place Road, is an east–west state highway in Fentress County, Tennessee, connecting Jamestown with Allardt.
State Route 297 is a 62.0-mile-long (99.8 km) east–west secondary state highway in Middle and East Tennessee. It is the primary road in and out of Scott State Forest and Big South Fork National River and Recreation Area, where it is known as Leatherwood Ford Road.
State Route 334, also known as Louisville Road, is 2.5 mile long north-south state highway in Blount County, Tennessee. It serves as a connector between the town of Louisville and the city of Alcoa.
State Route 142 is a 24.59 mile long east-west state highway in West Tennessee.
State Route 188 is a 22.2-mile-long (35.7 km) north–south state highway in West Tennessee, connecting the towns of Maury City and Alamo with Yorkville via Crockett Mills and Eaton.
State Route 189 is a short 5.5-mile-long (8.9 km) north–south state highway in Crockett County, Tennessee, connecting the towns of Maury City and Friendship.
State Route 190 is a 55.3-mile-long (89.0 km) north–south state highway that traverses the farmland of West Tennessee. It connects Trezevant and South Fulton via Pillowville, Gleason, Palmersville, and Latham.
State Route 201 is a 23.0 mile long north-south state highway in West Tennessee.
State Route 216 is a 17.7-mile-long (28.5 km) east–west state highway in West Tennessee, connecting Rives with Martin.
State Route 443 is a 12.2-mile-long (19.6 km) east–west state highway in East Tennessee, connecting SR 30 with the communities of New Harmony and Ogden along with other rural areas, which is primarily farmland.
State Route 224 is a 26.6 miles (42.8 km) north-south state highway that is located almost entirely in McNairy County, Tennessee, connecting Michie with Enville via Stantonville and Adamsville.
State Route 269 is a 49.2-mile-long (79.2 km) east–west state highway in central Middle Tennessee.
State Route 273 is a 36.9-mile-long (59.4 km) east–west state highway traversing the hills of southern Middle Tennessee.
State Route 373 is a 17.1-mile-long (27.5 km) east-west state highway in southern Middle Tennessee. It connects the community of Culleoka with the cities of Lewisburg and Columbia, along with I-65.
US 321 / SR 67 in Johnson City 
US 11E / US 19W in North Johnson City
