Thevetin

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Thevetins are a group of poisonous cardiac glycosides. They are obtained especially from the seeds of a West Indian shrub or small tree ( Cascabela thevetia syn. Thevetia nereifolia) of the dogbane family (Apocynaceae). [1] Hydrolysis products include glucose, digitalose, and a sterol. [1]

Cardiac glycosides are a class of organic compounds that increase the output force of the heart and increase its rate of contractions by acting on the cellular sodium-potassium ATPase pump. Their beneficial medical uses are as treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity prevents them from being widely used. Most commonly found as secondary metabolites in several plants such as foxglove plants, these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment.

West Indies Island region in the Caribbean

The West Indies is a region of the North Atlantic Ocean and the Caribbean that includes the island countries and surrounding waters of three major archipelagos: the Greater Antilles, the Lesser Antilles and the Lucayan Archipelago.

<i>Cascabela thevetia</i> species of plant

Cascabela thevetia is a poisonous plant native throughout Mexico and in Central America, and cultivated widely as an ornamental. It is a relative of Nerium oleander, giving it a common name yellow oleander, and is also called lucky nut in the West Indies.

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Peruvoside chemical compound

Peruvoside is a cardiac glycoside for heart failure.

<i>Thevetia</i> genus of plants

Thevetia is a genus of flowering plants in the dogbane family, Apocynaceae, first described for modern science as a genus in 1758. It is native to Mexico, Central America, South America, and Cuba. The taxonomy of the genus is controversial, with some authors including Cascabela within Thevetia, while others accept the two genera as separate.

Oleandrin chemical compound

Oleandrin is a toxic cardiac glycoside found in oleander. Along with neandrin it is primarily responsible for the toxicity of the sap of oleander. Oleandrin has been used for many years in China and Russia for its properties as a cardiac glycoside, for both suicidal and therapeutic purposes as in treatment of cardiac insufficiency.

References

  1. 1 2 "Thevetin". merriam-webster.com.