Thymosin beta-4, Y-chromosomal

Last updated
TMSB4Y
Identifiers
Aliases TMSB4Y , TB4Y, thymosin beta 4, Y-linked, thymosin beta 4 Y-linked
External IDs OMIM: 400017 GeneCards: TMSB4Y
Gene location (Human)
Ideogram human chromosome Y.svg
Chr. Y chromosome (human) [1]
Human chromosome Y ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band Yq11.221Start13,703,899 bp [1]
End13,706,024 bp [1]
RNA expression pattern
PBB GE TMSB4Y 206769 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004202

n/a

RefSeq (protein)

NP_004193

n/a

Location (UCSC) Chr Y: 13.7 – 13.71 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Thymosin beta-4, Y-chromosomal is a protein that in humans is encoded by the TMSB4Y gene. [3] [4]

Contents

The protein consists (in humans) of 44 amino acids (msdkpgmaei ekfdksklkk tetqeknpls sketieqerq ages) MolWt 4881. [5]

Function

This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X (thymosin beta-4) escapes X inactivation and encodes an actin sequestering protein. [4]

Related Research Articles

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Beta-actin protein-coding gene in the species Homo sapiens

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ACTC1 protein-coding gene in the species Homo sapiens

ACTC1 encodes cardiac muscle alpha actin. This isoform differs from the alpha actin that is expressed in skeletal muscle, ACTA1. Alpha cardiac actin is the major protein of the thin filament in cardiac sarcomeres, which are responsible for muscle contraction and generation of force to support the pump function of the heart.

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ACTG2 protein-coding gene in the species Homo sapiens

Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.

TMSB10 protein-coding gene in the species Homo sapiens

Thymosin beta-10 is a protein that in humans is encoded by the TMSB10 gene. TMSB10 is a member of the beta-thymosin are a family of peptides.

Tropomodulin 1 protein-coding gene in the species Homo sapiens

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.

CAP1 gene of the species Homo sapiens

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EIF1AX protein-coding gene in the species Homo sapiens

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CDY1 protein-coding gene in the species Homo sapiens

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UTY (gene) protein-coding gene in the species Homo sapiens

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.

UTX (gene) protein-coding gene in the species Homo sapiens

Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene. It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.

Thymosin beta-4 mammalian protein found in Homo sapiens

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EIF1AY protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.

BPY2 protein-coding gene in the species Homo sapiens

Testis-specific basic protein Y 2 also known as basic charge, Y-linked 2 is a protein that in humans is encoded by the BPY2 gene which resides on the Y chromosome.

TMSB15A protein-coding gene in the species Homo sapiens

Thymosin beta-15A is a protein that in humans is encoded by the TMSB15A gene.

Thymosin beta-15B is a protein that, in humans, is encoded by the TMSB15B gene. The protein is identical in aminoacid sequence to Thymosin beta-15A, product of the TMSB15A gene, although synthesis of the two proteins is independently regulated.

Beta thymosins

Beta thymosins are a family of proteins which have in common a sequence of about 40 amino acids similar to the small protein thymosin β4. They are found almost exclusively in multicellular animals. Thymosin β4 was originally obtained from the thymus in company with several other small proteins which although named collectively "thymosins" are now known to be structurally and genetically unrelated and present in many different animal tissues.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154620 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID   9381176.
  4. 1 2 "Entrez Gene: TMSB4Y thymosin, beta 4, Y-linked".
  5. https://www.ncbi.nlm.nih.gov/protein/NP_004193

Further reading