Thymosin beta-4, Y-chromosomal

Last updated
TMSB4Y
Identifiers
Aliases TMSB4Y , TB4Y, thymosin beta 4, Y-linked, thymosin beta 4 Y-linked
External IDs OMIM: 400017 GeneCards: TMSB4Y
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004202

n/a

RefSeq (protein)

NP_004193

n/a

Location (UCSC) Chr Y: 13.7 – 13.71 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Thymosin beta-4, Y-chromosomal is a protein that in humans is encoded by the TMSB4Y gene. [3] [4]

Contents

The protein consists (in humans) of 44 amino acids (msdkpgmaei ekfdksklkk tetqeknpls sketieqerq ages) MolWt 4881. [5]

Function

This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X (thymosin beta-4) escapes X inactivation and encodes an actin sequestering protein. [4]

Related Research Articles

Actin, alpha 1

Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene.

ACTG1

Gamma-actin is a protein that in humans is encoded by the ACTG1 gene. Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle cells. Mutations in ACTG1 have been associated with nonsyndromic hearing loss and Baraitser-Winter syndrome, as well as susceptibility of adolescent patients to vincristine toxicity.

ACTG2

Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.

TMSB10

Thymosin beta-10 is a protein that in humans is encoded by the TMSB10 gene. TMSB10 is a member of the beta-thymosin family of peptides.

Tropomodulin 1

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.

CAP1

Adenylyl cyclase-associated protein 1 is an enzyme that in humans is encoded by the CAP1 gene.

EIF1AX

Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene. This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.

CDY1

Testis-specific chromodomain protein Y 1 is a protein that in humans is encoded by the CDY1 gene.

FBLIM1

Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.

UTY (gene)

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.

B3GAT3

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.

ALS2CR2

STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.

UTX (gene)

Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene. It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.

Thymosin beta-4

Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene. Recommended INN for thymosin beta-4 is 'timbetasin', as published by the World Health Organization (WHO).

ACTR3B

Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.

EIF1AY

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.

BPY2

Testis-specific basic protein Y 2 also known as basic charge, Y-linked 2 is a protein that in humans is encoded by the BPY2 gene which resides on the Y chromosome.

TMSB15A Protein-coding gene in the species Homo sapiens

Thymosin beta-15A is a protein that in humans is encoded by the TMSB15A gene.

Thymosin beta-15B is a protein that, in humans, is encoded by the TMSB15B gene. The protein is identical in aminoacid sequence to Thymosin beta-15A, product of the TMSB15A gene, although synthesis of the two proteins is independently regulated.

Beta thymosins

Beta thymosins are a family of proteins which have in common a sequence of about 40 amino acids similar to the small protein thymosin β4. They are found almost exclusively in multicellular animals. Thymosin β4 was originally obtained from the thymus in company with several other small proteins which although named collectively "thymosins" are now known to be structurally and genetically unrelated and present in many different animal tissues.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154620 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID   9381176.
  4. 1 2 "Entrez Gene: TMSB4Y thymosin, beta 4, Y-linked".
  5. https://www.ncbi.nlm.nih.gov/protein/NP_004193

Further reading