Touch DNA

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Touch DNA, also known as Trace DNA, is a forensic method for analyzing DNA left at the scene of a crime. It is called "touch DNA" because it only requires very small samples, for example from the skin cells left on an object after it has been touched or casually handled, [1] or from footprints. [2] Touch DNA analysis only requires seven or eight cells from the outermost layer of human skin. [3] The technique has been criticized for high rates of false positives due to contamination—for example, fingerprint brushes used by crime scene investigators can transfer trace amounts of skin cells from one surface to another, leading to inaccurate results. [4] [5] Because of the risk of false positives, it is more often used by the defense to help exclude a suspect rather than the prosecution. [6]

Contents

The technique is very similar to Low Copy Number DNA analysis, to the extent that court rulings have sometimes confused the two. [7] However, in LCN DNA analysis, the DNA goes through additional cycles of PCR amplification. [7]

Method

Touch DNA relies on the STR analysis of cells collected off of objects. [8] Upon collection, the cells' DNA is extracted, and 13 genomic locations that vary among individuals are assessed to confirm suspects or exonerate those that are innocent. [9]

Notable use cases

United States

See also

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References

  1. Low Copy Number DNA Archived 2011-01-03 at the Wayback Machine – nfstc.org
  2. Dalén, Love; Göthenström, Anders; Meijer, Tomas; Shapiro, Beth. "Recovery of DNA from Footprints in the Snow" (PDF). Canadian Field-Naturalist. 121 (3): 321–324. Retrieved 2024-08-03.
  3. "What is touch DNA?". Scientific American. 2008-08-08.
  4. Low Copy Number DNA and The Forensic Institute Archived 2012-09-12 at archive.today
  5. Silverman, Mike (27 April 2014). "The strange case of the 'time travel' murder". BBC News. Retrieved 28 April 2014.
  6. Anderson, Chris (22 March 2012). "Tyson Case: Attorneys say use of touch DNA to show guilt is rare". Herald Tribune.
  7. 1 2 Disagreement on What to Call DNA Profiling with Really Small Samples Confuses Courts – Penn State University
  8. Cavanaugh, Sarah E.; Bathrick, Abigail S. (2018). "Direct PCR amplification of forensic touch and other challenging DNA samples: A review". Forensic Science International: Genetics. 32: 40–49. doi:10.1016/j.fsigen.2017.10.005. PMID   29059581.
  9. Houck, Max; Houck, Lucy. "What is touch DNA?". Scientific American.
  10. Hayes, Ashley (21 June 2011). "Prosecutors: Child of fellow Casey Anthony inmate drowned in pool". CNN.
  11. Kircher, Travis (8 October 2013). "David Camm Blog: Dr. Richard Eikelenboom and his Touch DNA". WDRB.
  12. "DNA clears JonBenet's family, points to mystery killer". CNN. 10 July 2008.
  13. Mikkilineni, Rupa (2 December 2008). "Tip line played key role in cracking cold case". CNN.
  14. Smith, Peter Andrey (2016). "When DNA Implicates the Innocent". Scientific American. 314 (6): 11–12. Bibcode:2016SciAm.314f..11S. doi:10.1038/scientificamerican0616-11. PMID   27196827.
  15. Leary, Mary (2017). "Touch DNA and Chemical Analysis of Skin Trace Evidence". William & Mary Bill of Rights Journal.