Trichosanthin

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PDB 1qd2 EBI.png
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Alt. namesα-Trichosanthin
CAS number 60318-52-7
UniProt P09989
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Structures Swiss-model
Domains InterPro

Trichosanthin is a ribosome-inactivating protein. [1] [2] It is derived from Trichosanthes kirilowii . [3] It is also an abortifacient. [4]

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References

  1. ↑ Too PH, Ma MK, Mak AN, et al. (February 2009). "The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome". Nucleic Acids Res. 37 (2): 602–10. doi:10.1093/nar/gkn922. PMC   2632931 . PMID   19073700.
  2. ↑ Shaw PC, Lee KM, Wong KB (May 2005). "Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties". Toxicon. 45 (6): 683–9. doi:10.1016/j.toxicon.2004.12.024. PMID   15804517.
  3. ↑ Zhao J, Ben LH, Wu YL, et al. (July 1999). "Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors". J. Exp. Med. 190 (1): 101–11. doi:10.1084/jem.190.1.101. PMC   2195565 . PMID   10429674.
  4. ↑ Li MX, Yeung HW, Pan LP, Chan SI (November 1991). "Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro". Nucleic Acids Res. 19 (22): 6309–12. doi:10.1093/nar/19.22.6309. PMC   329144 . PMID   1659689.


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