Tulane virus

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Tulane virus
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(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Picornavirales
Family: Caliciviridae
Genus: Recovirus
Species:
Recovirus tulani
Synonyms [1]
  • Recovirus A

Tulane virus (Recovirus tulani) is a calicivirus isolated from the rhesus monkey. [2] It is the sole member of the Recovirus genus. [3] It is a non-enveloped, positive-sense, single-stranded RNA virus, and its genome, which is approximately 6.7 kilobases in length, is reported shortest among the members of the family Caliciviridae . The genome is organized into three open reading frames (ORFs): ORF1 encodes a nonstructural polyprotein involved in viral replication, ORF2 endcodes the major capsid protein (VP1), and ORF3 encodes a basic minor structural protein (VP2) [4] .

The virus was first identified in 2008 after being isolated from the stool samples of captive juvenile rhesus macaques (Macaca mulatta) housed at the Tulane National Primate Research Center [4] . It propagates easily in cell lines such as LLC-MK2 [5] , and recognizes histo-blood group antigens (HBGAs) similar to human noroviruses (HuNoVs) [6] . These features make it a good surrogate candidate for HuNoV studies.

References

  1. ↑ "History of the taxon: Species: Recovirus tulani (2024 Release, MSL #40)". International Committee on Taxonomy of Viruses. Retrieved 20 March 2025.
  2. ↑ Farkas, Tibor (1 July 2015). "Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis". Journal of General Virology. 96 (7): 1504–1514. doi: 10.1099/jgv.0.000020 . PMID   25502652.
  3. ↑ "Genus: Recovirus - Caliciviridae - Positive-sense RNA Viruses". International Committee on Taxonomy of Viruses (ICTV). Archived from the original on August 29, 2021. Retrieved 3 September 2020.
  4. 1 2 Farkas, Tibor; Sestak, Karol; Wei, Chao; Jiang, Xi (June 2008). "Characterization of a Rhesus Monkey Calicivirus Representing a New Genus of Caliciviridae". Journal of Virology. 82 (11): 5408–5416. doi:10.1128/jvi.00070-08.
  5. ↑ Chhabra, Preeti; Ranjan, Priya; Cromeans, Theresa; Sambhara, Suryaprakash; Vinjé, Jan (2017-05-01). "Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection". Journal of General Virology. 98 (5): 1016–1026. doi:10.1099/jgv.0.000769. ISSN   0022-1317. PMC   5916764 . PMID   28530548.
  6. ↑ Zhang, Dongsheng; Huang, Pengwei; Zou, Lu; Lowary, Todd L.; Tan, Ming; Jiang, Xi (2014-01-02). "Tulane Virus Recognizes the A Type 3 and B Histo-Blood Group Antigens". Journal of Virology. 89 (2): 1419–1427. doi:10.1128/jvi.02595-14.


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