U6atac minor spliceosomal RNA

Last updated
U6atac minor spliceosomal RNA
RF00619.jpg
Identifiers
SymbolU6atac
Rfam RF00619
Other data
RNA type Gene; snRNA; splicing
Domain(s) Eukaryota
GO GO:0000355 GO:0000369 GO:0030622 GO:0030627 GO:0005691
SO SO:0000274
PDB structures PDBe

U6atac minor spliceosomal RNA is a non-coding RNA which is an essential component of the minor U12-type spliceosome complex. The U12-type spliceosome is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type). [1]

Contents

U6atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U4atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing. [2] U6atac is the functional analog of U6 spliceosomal RNA in the major U2-type spliceosomal complex. [2]

References

  1. Lorkovic ZJ, Lehner R, Forstner C, Barta A (2005). "Evolutionary conservation of minor U12-type spliceosome between plants and humans". RNA. 11 (7): 1095–1107. doi:10.1261/rna.2440305. PMC   1370794 . PMID   15987817.
  2. 1 2 Padgett RA, Shukla GC (2002). "A revised model for U4atac/U6atac snRNA base pairing". RNA. 8 (2): 125–128. doi:10.1017/S1355838202017156. PMC   1370236 . PMID   11911359.

Further reading