Uncoupling (neuropsychopharmacology)

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In neuropsychopharmacology, uncoupling, also known as decoupling, refers to the separation, shifting, or internalization of the brain's receptors (signal receivers) or ligands (signal senders) due to long-term exposure to mind-altering drugs or toxins, as the brain adapts through drug tolerance. [1] [2] [3]

For example, prolonged use of opioids like morphine can lead to uncoupling of opioid receptors, reducing their responsiveness over time. [4]

References

  1. ↑ Mize, Amy L; Alpher, Richard H. "Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17(beta)-estradiol in vitro requires protein kinases A and C". Neuroendocrinology. ProQuest   220112648.
  2. ↑ Ganguly, Prabarna; Holland, Freedom H; Brenhouse, Heather C. "Functional Uncoupling NMDAR NR2A Subunit from PSD-95 in the Prefrontal Cortex: Effects on Behavioral Dysfunction and Parvalbumin Loss after Early-Life Stress". Neuropsychopharmacology. ProQuest   1721699997.
  3. ↑ Williams, John T. (2014). "Opioid Receptors and Tolerance: Mechanisms of Uncoupling". Pharmacological Reviews. 66 (4): 1121–1141. doi:10.1124/pr.113.008540. hdl: 11392/2333165 . PMID   25387804.
  4. ↑ Stahl, Stephen M. (2021). Stahl's Essential Psychopharmacology. Cambridge University Press. pp. 89–92. ISBN   978-1-108-97363-2.


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