Vaccine refrigerator

Last updated

Vaccine refrigerators are designed to store vaccines and other medical products at a stable temperature to ensure they do not degrade. In developing countries with a sunny climate, solar-powered vaccine refrigerators are common.

Contents

Requirements for vaccine refrigeration

Data logging cable shown running through the door gasket, creating a gap which air can enter and escape through. Doorgasketrunningthroughdoor.jpg
Data logging cable shown running through the door gasket, creating a gap which air can enter and escape through.

Many vaccines must be stored at low temperatures, some below -15 °C, and others between 2 and 8 °C. [1] [2] as in an Ice Lined Refrigerator (ILR). If vaccines are not stored correctly they can lose their effectiveness.

According to the Center for Disease Control, failure to adhere to recommended specifications for storage and handling of immunobiologics can reduce or destroy their potency, resulting in inadequate or no immune response in the recipient. Maintenance of vaccine quality is the shared responsibility of all handlers of vaccines from the time a vaccine is manufactured until administration.

According to the Immunization Action Coalition, all vaccines should be stored in a refrigerator or freezer that is designed specifically for the storage of biologics or, alternatively, in a separate dedicated unit. A dorm-style combination refrigerator-freezer unit with just one exterior door has been shown[ citation needed ] to be unacceptable no matter where the vaccine was placed inside the unit. Stand-alone refrigerator or freezer units are best for storage needs. With retail pharmacies playing a major role in pneumonia, influenza and shingles immunization programs, the value of critical vaccines being stored in pharmacy refrigerators has increased. In 2022, it is not uncommon for many pharmacies to have over $100,000 of product in a single refrigerator during peak seasons.

It is estimated that $20 million is wasted annually from poor refrigeration[ citation needed ], and up to 35% of vaccines are affected by improper storage. Accurate and uniform temperature in a refrigerator plays a key role in ensuring the life of vaccines, reagents and other biologicals. Research has shown that minor variances in temperature such as those in a household refrigerator can compromise the effectiveness of your biologicals, risking up to thousands of dollars in valuable contents.

Vaccines are also compromised through improper use of the door gasket to feed cables from data loggers and thermometers, allowing excess warm air in, and cold air out of the refrigerator or freezer. Over time this causes the compressor to work a longer duty cycle and eventually leads to failure. This can be remedied by using probe access ports, found on most clinical refrigerators and freezer. These are easy to open up and drastically reduce air intake and loss from inside the units. [3] [4]

Solar powered vaccine refrigerators

In developing countries the electricity grid often does not reach rural areas, and is not always reliable. As keeping vaccines at the appropriate temperature is vital, Solar powered refrigerators are a cost-effective alternative that can be highly reliable. A typical system will use a solar photovoltaic panel to generate electricity from sunlight, and a deep cycle battery to store energy for operation overnight, although newer fridges which have revolutionary Sure Chill Technology or Direct Drive technology do not need batteries to maintain temperatures for many days without sunlight.

WHO prequalified products

The World Health Organization Immunization Devices Prequalification (IMD-PQS) [5] programme maintains a list of immunization cold chain equipment that it has prequalified for procurement and use by national immunization programmes of the WHOs Expanded Programme on Immunization (EPI), including refrigerators. [6] IMD-PQS prequalifies products based on rigorous performance specifications that it develops in collaboration with national immunization programmes and in consultation with product manufacturers, to ensure that products address the specific needs of immunization programmes’ operating environments.

See also

Related Research Articles

<span class="mw-page-title-main">Refrigeration</span> Process of moving heat from one location to another in controlled conditions

Refrigeration is any of various types of cooling of a space, substance, or system to lower and/or maintain its temperature below the ambient one. Refrigeration is an artificial, or human-made, cooling method.

<span class="mw-page-title-main">Frozen food</span> Food stored at temperatures below the freezing point of water, for extending its shelf life

Freezing food preserves it from the time it is prepared to the time it is eaten. Since early times, farmers, fishermen, and trappers have preserved grains and produce in unheated buildings during the winter season. Freezing food slows decomposition by turning residual moisture into ice, inhibiting the growth of most bacterial species. In the food commodity industry, there are two processes: mechanical and cryogenic. The freezing kinetics is important to preserve the food quality and texture. Quicker freezing generates smaller ice crystals and maintains cellular structure. Cryogenic freezing is the quickest freezing technology available due to the ultra low liquid nitrogen temperature −196 °C (−320 °F).

<span class="mw-page-title-main">Refrigerator</span> Appliance for cold food storage

A refrigerator, colloquially fridge, is a commercial and home appliance consisting of a thermally insulated compartment and a heat pump that transfers heat from its inside to its external environment so that its inside is cooled to a temperature below the room temperature. Refrigeration is an essential food storage technique around the world. The lower temperature lowers the reproduction rate of bacteria, so the refrigerator reduces the rate of spoilage. A refrigerator maintains a temperature a few degrees above the freezing point of water. The optimal temperature range for perishable food storage is 3 to 5 °C. A similar device that maintains a temperature below the freezing point of water is called a freezer. The refrigerator replaced the icebox, which had been a common household appliance for almost a century and a half. The United States Food and Drug Administration recommends that the refrigerator be kept at or below 4 °C (40 °F) and that the freezer be regulated at −18 °C (0 °F).

<span class="mw-page-title-main">Kegerator</span> Refrigerator made to store and dispense kegs

Kegerator, a portmanteau of the words keg and refrigerator, is a refrigerator that has been designed or altered to store and dispense kegs.

Auto-defrost, automatic defrost or self-defrosting is a technique which regularly defrosts the evaporator in a refrigerator or freezer. Appliances using this technique are often called frost free, frostless, or no-frost.

<span class="mw-page-title-main">Ice pack</span> Filled bag designed to be frozen

An ice pack or gel pack is a portable bag filled with water, refrigerant gel, or liquid, meant to provide cooling. They can be divided into the reusable type, which works as a thermal mass and requires freezing, or the instant type, which cools itself down using chemicals but can only be used once. The instant type is generally limited to medical use as a cold compress to alleviate the pain of minor injuries, while the reusable type is both used as a cold compress and to keep food cool in portable coolers or in insulated shipping containers to keep products cool during transport.

<span class="mw-page-title-main">Cold chain</span> Low-temperature supply chain

Cold chain is defined as the series of actions and equipment applied to maintain a product within a specified low-temperature range from harvest/production to consumption. An unbroken cold chain is an uninterrupted sequence of refrigerated production, storage and distribution activities, along with associated equipment and logistics, which maintain a desired low-temperature interval to keep the safety and quality of perishable or sensitive products, such as foods and medicines. In other words, the term denotes a low temperature-controlled supply chain network used to ensure and extend the shelf life of products, e.g. fresh agricultural produce, seafood, frozen food, photographic film, chemicals, and pharmaceutical products. Such products, during transport and end-use when in transient storage, are sometimes called cool cargo. Unlike other goods or merchandise, cold chain goods are perishable and always en-route towards end use or destination, even when held temporarily in cold stores and hence commonly referred to as "cargo" during its entire logistics cycle. Adequate cold storage, in particular, can be crucial to prevent quantitative and qualitative food losses.

<span class="mw-page-title-main">Solar Electric Light Fund</span> Solar power

The Solar Electric Light Fund (SELF) is a non-profit organization whose mission is to design, fund and implement solar energy solutions to benefit those in poor rural communities without access to an electrical grid. This allows students to study at night and brings computers and Internet into schools. It makes it possible to bring in water for irrigation without having to hand-carry it long distances, allowing women to spend their time on money-earning enterprises. Access to electricity and water improves health care. SELF has completed several projects in more than 20 countries including a solar powered drip irrigation in Benin, a health care centre in Haiti, telemedicine in the Amazon rainforest, online learning platform in South Africa, and a microenterprise development in Nigeria.

<span class="mw-page-title-main">Icemaker</span>

An icemaker, ice generator, or ice machine may refer to either a consumer device for making ice, found inside a home freezer; a stand-alone appliance for making ice, or an industrial machine for making ice on a large scale. The term "ice machine" usually refers to the stand-alone appliance.

<span class="mw-page-title-main">Pot-in-pot refrigerator</span> Non-electric method of refrigeration

A pot-in-pot refrigerator, clay pot cooler or zeer is an evaporative cooling refrigeration device which does not use electricity. It uses a porous outer clay pot containing an inner pot within which the food is placed. The evaporation of the outer liquid draws heat from the inner pot. The device can cool any substance, and requires only a flow of relatively dry air and a source of water.

The Expanded Program on Immunization(EPI) in the Philippines began in July 1979. And, in 1986, made a response to the Universal Child Immunization goal. The four major strategies include:

  1. sustaining high routine Full Immunized Child (FIC) coverage of at least 90% in all provinces and cities;
  2. sustaining the polio-free country for global certification;
  3. eliminating measles by 2008; and
  4. eliminating neonatal tetanus by 2008.
<span class="mw-page-title-main">Solar-powered refrigerator</span>

A solar-powered refrigerator is a refrigerator which runs on energy directly provided by sun, and may include photovoltaic or solar thermal energy.

<span class="mw-page-title-main">Food storage container</span>

Food storage containers are widespread in use throughout the world and have probably been in use since the first human civilizations.

<span class="mw-page-title-main">Refrigerator death</span> Death that may occur due to suffocation inside a refrigerator

A refrigerator death is death by suffocation in a refrigerator or other air-tight appliance. Because, by design, such appliances are air-tight when closed, a person entrapped inside will have a low supply of oxygen. Early refrigerators could only be opened from the outside, making accidental entrapment a possibility, particularly of children playing with discarded appliances; many such deaths have been recorded. Modern designs close with a magnetic mechanism that can be opened from the inside, reducing the danger of accidental entrapment.

Sure Chill Technology is a cooling technology that is currently being used in medical refrigerators, but is thought to have wider potential in the future for domestic refrigerators and beverage coolers. According to BBC, the refrigerator's temperature 'can stay at 4°C for more than 10 days without power, and is used mainly in Africa' to store vaccines and other medical supplies. It can be powered by electricity or solar, and uses the physics of water to store energy, thus not relying on batteries.

PfSPZ Vaccine is a metabolically active non-replicating whole sporozoite (SPZ) malaria vaccine being developed by Sanaria against Plasmodium falciparum (Pf) malaria. Clinical trials have been safe, extremely well tolerated and highly efficacious. The first generation PfSPZ product is attenuated by gamma irradiation; the second generation vaccines PfSPZ-CVac and PfSPZ LARC2 are, respectively, attenuated chemically and genetically. Multiple studies are ongoing with trials of the PfSPZ vaccines. All three products are produced using the same manufacturing process. These products are stored and distributed below -150 °C using liquid nitrogen (LN2) vapor phase (LNVP) freezers and cryoshippers.

<span class="mw-page-title-main">Summit Appliance</span>

Summit Appliance is the residential product division of Felix Storch, Inc (FSI). It was founded and trademarked in 1969 and is now headquartered in the Bronx, New York City, where their manufacturing and operations are done. They have additional warehousing facilities in Edison, New Jersey. Summit is both an importer and manufacturer of appliances. Internationally, it sources products from manufacturers in Europe, South America, North America, and Asia. Many products are built or modified in its Bronx manufacturing facilities, for which it is recognized as a “Made In NYC” partner.

<span class="mw-page-title-main">ULT freezer</span> Freezer used for storing contents at unusually low temperatures

An ultra low temperature (ULT) freezer is a refrigerator that stores contents at −40 to −86 °C. An ultra low temperature freezer is commonly referred to as a "minus 80 freezer" or a "negative 80 freezer", referring to the most common temperature standard. ULT freezers come in upright and chest freezer formats.

Many vaccines require refrigeration to remain active, and the lack of infrastructure to maintain the cool chain to reliably bring vaccines into more remote areas of developing countries poses a serious challenge to national immunization programs. Portable vaccine cooler units have been proposed by several technologists. The WHO Performance, Quality and Safety (PQS) programme is a driver of the technology.

<span class="mw-page-title-main">Vaccine storage</span>

Vaccine storage relates to the proper vaccine storage and handling practices from their manufacture to the administration in people. The general standard is the 2–8 °C cold chain for vaccine storage and transportation. This is used for all current US Food and Drug Administration (FDA)-licensed human vaccines and in low and middle-income countries. Exceptions include some vaccines for smallpox, chickenpox, shingles and one of the measles, mumps, and rubella II vaccines, which are transported between −25 °C and −15 °C. Some vaccines, such as the COVID-19 vaccine, require a cooler temperature between −80 °C and −60 °C for storage.

References

  1. Vaccine Handling Tips, Immunization Action Coalition
  2. KXN Nigeria Ltd, Nigeria: PV-powered vaccine fridges Archived 2008-11-09 at the Wayback Machine , Ashden Awards
  3. "How to Properly use a Probe Access Port for Sample Storage". Get Informed. 2017-05-19. Retrieved 2017-06-06.
  4. "Tips to Choose the Perfect Medical Refrigerators For Hospital and Laboratory".
  5. WHO Immunization Devices Prequalification
  6. WHO IMD-PQS Catalogue of Prequalified products