Vibrio cholerae ToxT activated RNAs

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In molecular biology, Vibrio cholerae ToxT activated RNAs are small RNAs which are produced by the bacterium Vibrio cholerae . They are regulated by the transcriptional activator ToxT and may play a role in V. cholerae virulence. [1] Two ToxT activated RNAs have been described: TarA (ToxT activated RNA A) and TarB (ToxT activated RNA B).

Contents

TarA

The TarA small RNA regulates PtsG, a glucose transporter involved in the regulation of glucose uptake. Regulation of PtsG by TarA may be dependent upon the Hfq protein, an RNA chaperone. [2]

TarB

TarB inhibits the expression of Toxin coregulated pilus biosynthesis protein F (TcpF). It does not act in conjunction with Hfq. [3]

See also

References

  1. ↑ Bardill JP, Hammer BK (April 2012). "Non-coding sRNAs regulate virulence in the bacterial pathogen Vibrio cholerae". RNA Biology. 9 (4): 392–401. doi:10.4161/rna.19975. PMC   3384565 . PMID   22546941.
  2. ↑ Richard AL, Withey JH, Beyhan S, Yildiz F, DiRita VJ (December 2010). "The Vibrio cholerae virulence regulatory cascade controls glucose uptake through activation of TarA, a small regulatory RNA". Molecular Microbiology. 78 (5): 1171–1181. doi:10.1111/j.1365-2958.2010.07397.x. PMC   3064952 . PMID   21091503.
  3. ↑ Bradley ES, Bodi K, Ismail AM, Camilli A (July 2011). "A genome-wide approach to discovery of small RNAs involved in regulation of virulence in Vibrio cholerae". PLOS Pathogens. 7 (7) e1002126. doi: 10.1371/journal.ppat.1002126 . PMC   3136459 . PMID   21779167.
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