Plot
We3, a squad of three prototype "animal weapons", are part of a government project headed by Dr. Rosanne Berry and her superior Doctor Trendle. The group consists of a dog, "Bandit" a.k.a. "1"; a cat, "Tinker" a.k.a. "2"; and a rabbit, "Pirate" a.k.a. "3", who were all kidnapped from a nearby city and encased in robotic armor. They have also been given a limited ability to speak through skull implants. Their body armor fields numerous weapons, including mine laying devices, machine guns and razor claws.
After the group carries out another successful assignment of assassinating U.S. enemies, a senator makes a visit to the project's facility to see it, where he congratulates the project staff members, only for the General in charge of the project to decide afterwards to decommission We3 in favor of creating newer animal weapons. Berry, unwilling to end the lives of the three animals, instead has them break free. Feeling guilt over her part in what has been done to them, she hopes to be killed by them in the process of their escape; to her surprise, they leave her alive. She is taken into custody by the government while Trendle works closely with the General and the military to terminate We3.
We3 escape into the wild and, confused by their new surroundings, decide to look for "HOME". They are later found and chased by the military, but they manage to brutally kill the attacking soldiers thanks to their cybernetic enhancements. Trendle decides to send his cybernetic enhanced rats to attack We3, telling Berry that if the rats fail the military will use her to lure We3 back. While fighting the rats on a bridge, Pirate drops several landmines after spotting an oncoming train. The mines explode causing the train to derail and fall into the lake below. Bandit attempts to rescue the conductor, but Tinker points out that the man is already dead. Pirate is nowhere to be seen.
Bandit and Tinker manage to find Pirate, but Pirate is in a confrontation with a family who mistake Pirate for an alien. Pirate ends up getting shot in the head by the father, damaging his speech. Angered, Bandit and Tinker kill the father and the family's dog, but leave the boy alive. Realizing that the situation is getting far worse, the military send out We4, an enhanced English Mastiff, against the wishes of Berry.
We3 take refuge in a homeless man's domain and gain his sympathy. The homeless man encounters the military who have the police escort him from the area, while the man claims that he didn't see anything. Setting up around the area, the military unleash We4, who kills Pirate but is in turn damaged by one of Pirate's mines in the process. Berry is then sent by the military to calm Bandit and lead him into military sniper fire, but as the snipers prepare to take out Bandit, she instead tells him his real name and sacrifices herself by jumping in the way of the sniper bullets. Enraged, Bandit and Tinker both brutally attack We4 and all combatants end up breaking through a wall onto the highway, causing a car pile up. We4 begins to attack a police officer whom Bandit then rescues. At Trendle's insistence, the military terminate We4 from afar using a code word to trigger a bomb in We4's head.
Bandit and Tinker escape and, with painful effort, shed their armor, leaving it to explode and taking out some more soldiers on their trail. The homeless man manages to find them again and he removes the two's remaining cybernetic enhancements. Trendle then speaks out against the government's actions, and it is revealed that the now normal Bandit and Tinker have been taken into the care of the homeless man. As he compliments how well behaved the animals are, Trendle gives hundreds of dollars to the homeless man before walking up the steps of the courthouse to a crowd of reporters.
