U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is in Portal, North Dakota at the Canada–United States border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.
U.S. Route 19 or U.S. Highway 19 (US 19) is a north–south United States Numbered Highway in the Eastern United States. Despite encroaching Interstate Highways, the route has remained a long-haul road, connecting the Gulf of Mexico with Lake Erie.
U.S. Route 211 is a spur of US 11 in the U.S. state of Virginia. Known for most of its length as Lee Highway, the U.S. Highway runs 59.09 miles (95.10 km) from Interstate 81 (I-81) and Virginia State Route 211 in New Market east to US 15 Business, US 29 Business, and US 211 Business in Warrenton. US 211 connects the Shenandoah Valley with the Piedmont town of Warrenton via Luray and Sperryville, where the highway runs concurrently with US 340 and US 522, respectively.
U.S. Route 522 is a spur route of US 22 in the states of Virginia, West Virginia, Maryland, and Pennsylvania. The U.S. Highway travels in a north-south direction, and runs 308.59 miles (496.63 km) from US 60 near Powhatan, Virginia, to its northern terminus at US 11 and US 15 near Selinsgrove, Pennsylvania. US 522 serves many small cities and towns in the Piedmont, Blue Ridge Mountains, and northern Shenandoah Valley of Virginia. The highway serves the Virginia communities of Goochland, Mineral, Culpeper, the town of Washington, and Front Royal and the independent city of Winchester. US 522 then follows the Ridge-and-Valley Appalachians north and then east through the Eastern Panhandle of West Virginia, a 2-mile-wide (3.2 km) stretch of Western Maryland, and South Central Pennsylvania to its terminus in the Susquehanna Valley. The highway serves Berkeley Springs, West Virginia; Hancock, Maryland; and the Pennsylvania communities of McConnellsburg, Mount Union, Lewistown, and Middleburg.
U.S. Route 340 is a spur route of US 40, and runs from Greenville, Virginia, to Frederick, Maryland. In Virginia, it runs north–south, parallel and east of US 11, from US 11 north of Greenville via Waynesboro, Grottoes, Elkton, Luray, Front Royal, and Berryville to the West Virginia state line. A short separate piece crosses northern Loudoun County on its way from West Virginia to Maryland.
U.S. Route 220 (US 220) is a spur route of US 20. It runs in a north–south layout in the eastern United States, unlike its parent route as well as conventionally even-numbered highways which run east-west. US 220 extends for 678 miles (1,091 km) from an intersection with US 1 in Rockingham, North Carolina, to its interchange with the Southern Tier Expressway in South Waverly, Pennsylvania. Some sections of the route are part of the Appalachian Development Highway System's Corridor O as well as I-73 in North Carolina. US 220 is designated as a spur route of US 20 but the route does not intersect US 20 or connect to other spurs of US 20.
West Virginia Route 45 is a state highway in the U.S. state of West Virginia. The state highway runs 25.8 miles (41.5 km) from the Virginia state line near Glengary east to WV 230 and WV 480 in Shepherdstown. WV 45 connects the communities of Glengary and Arden in southwestern Berkeley County with the county seat of Martinsburg. The state highway also connects Shepherdstown in northern Jefferson County with Martinsburg, where the highway meets Interstate 81 (I-81), U.S. Route 11, and WV 9.
West Virginia Route 51 is a state highway that runs west to east from Berkeley County to Jefferson County in West Virginia's Eastern Panhandle. The western terminus is at WV 45 northwest of Gerrardstown. The eastern terminus is at an interchange with U.S. Route 340 and WV 9 east of downtown Charles Town. US 340 continues to the east on the same roadway as WV 51.
State Route 259 is a primary state highway in the U.S. state of Virginia. The state highway runs a total of 26.80 miles (43.13 km) in two sections. The southern section, in northern Rockingham County, has a length of 21.81 miles (35.10 km) from Interstate 81 (I-81) and U.S. Route 11 at Mauzy through Broadway to the West Virginia state line into Mathias. The northern section, in western Frederick County, covers 4.99 miles (8.03 km) from the West Virginia state line north to US 50 at Gore. The two sections of SR 259 are joined by West Virginia Route 259.
West Virginia Route 622 is a north–south state highway located entirely in Kanawha County, West Virginia. The southern terminus of the route is at West Virginia Route 25 west of Institute. The northern terminus is at Interstate 77 exit 114 north of Pocatalico.
West Virginia Route 527 is a north–south state highway located entirely in Huntington, West Virginia. The southern terminus of the route is at Interstate 64 exit 8, where WV 527 becomes West Virginia Route 152 upon crossing the expressway. The northern terminus is on the West Virginia Department of Transportation-maintained Robert C. Byrd Bridge, better known as the Sixth Street Bridge, where the route becomes State Route 527 upon crossing into Ohio. In Ohio, SR 527 continues northward to State Route 7 in Chesapeake.
Maryland Route 144 is a collection of state highways in the U.S. state of Maryland. These highways are sections of old alignment of U.S. Route 40 between Cumberland and Baltimore. Along with US 40 Scenic, US 40 Alternate, and a few sections of county-maintained highway, MD 144 is assigned to what was once the main highway between the two cities, connecting those endpoints with Hancock, Hagerstown, Frederick, New Market, Mount Airy, Ellicott City, and Catonsville. MD 144 has seven disjoint sections of mainline highway that pass through the Appalachian Mountains in Allegany and Washington counties and the rolling Piedmont of Frederick, Carroll, Howard, and Baltimore counties.
U.S. Route 52 (US 52) skirts the western fringes of the U.S. state of West Virginia. It runs from the Virginia state line near Bluefield, where it is concurrent with Interstate 77 (I-77), in a general northwest and north direction to I-64 at Kenova. There it turns east, overlapping I-64 for five miles (8.0 km) before splitting off onto the West Huntington Expressway into Ohio via the West Huntington Bridge. Despite having an even number, US 52 is signed north–south in West Virginia. In some other states along its route, it is signed east-west. The West Virginia segment is signed such that US 52 north corresponds to the general westward direction of the highway, and vice versa. For a while, US 52 parallels US 23, which is on the other side of the Big Sandy River in Kentucky. This continues into Ohio, where US 52 travels on the Ohio side of the Ohio River while US 23 travels on the Kentucky side.
U.S. Route 19 (US 19) is a part of the United States Numbered Highway System that runs from Memphis, Florida, to Erie, Pennsylvania. In Virginia, the highway runs 88.89 miles (143.05 km) between two pairs of twin cities: Bristol, Tennessee, and Bristol, Virginia, at the Virginia–Tennessee state line, and Bluefield, Virginia, and Bluefield, West Virginia, at the Virginia–West Virginia state line. Between its endpoints, US 19 has lengthy concurrencies with US 11, US 58 Alternate, and US 460 during its course connecting Abingdon, Lebanon, and Tazewell within Washington, Russell, and Tazewell counties in Southwest Virginia.
State Route 598 is a primary state highway in the U.S. state of Virginia. Known as East River Mountain Road, the state highway runs 4.16 miles (6.69 km) from Interstate 77 (I-77) and U.S. Route 52 near Rocky Gap north to the West Virginia state line near Bluefield, West Virginia, where the highway continues as West Virginia Route 598. SR 598 is the old alignment of US 52 on East River Mountain in far northern Bland County.
Corridor Q is a highway in the U.S. states of Kentucky, Virginia, and West Virginia. It is part of the Appalachian Development Highway System and U.S. Route 460. Corridor Q runs from Corridor B near Pikeville, Kentucky, easterly to Interstate 81 in Christiansburg, Virginia.
Virginia State Route 102 and West Virginia Route 102 are adjoining state highways in the U.S. states of Virginia and West Virginia. The two state highways together run 11.4 miles (18.3 km) from Center Street in Pocahontas, Virginia east to the Virginia – West Virginia state line between the twin cities of Bluefield, Virginia and Bluefield, West Virginia. Most of Route 102 consists of three sections in Virginia maintained by the Virginia Department of Transportation (VDOT); the two intervening sections in West Virginia are maintained by the West Virginia Division of Highways. In addition to connecting Pocahontas with the two Bluefields, the state highway passes through Nemours, West Virginia and Falls Mills, Virginia and provides access to Bluefield College.
At least 17 special routes of U.S. Route 11 (US 11) and at least one of US 11E have existed.
A total of at least sixteen special routes of U.S. Route 460 exist and at least six have been deleted.
SR 598 near Bluefield 
US 460 in Bluefield
US 52 in Bluefield
