Wickett's Remedy is a 2005 historical novel [1] by Myla Goldberg, about the 1918 influenza epidemic. It was published by Doubleday.
The novel makes heavy use of annotations, marginalia, and false documents to support its premise; [2] Goldberg has stated that Vladimir Nabokov's Pale Fire was a major influence on her in this respect. [3]
In 1918 Boston, Lydia Kilkenny is a sales clerk who marries medical student Henry Wickett. When Henry, and most of her relatives, die of the "Spanish flu", Lydia becomes a nurse, and works to help find a cure by assisting in medical experiments on convicted Navy deserters. She also continues to sell Henry's patent medicine (the Remedy of the title) [4] until Henry's business partner repackages it as a soft drink. [5]
In The New York Times , Andrea Barrett described it as "ambitious", "thoroughly researched", and "admirable", with "a set of nightmarish, wonderfully well-written chapters that would have made a strong short novel all on their own", but felt that it was a "somewhat uneasy mixture" of emotional fiction and historical fact; as well, Barrett considered that the novel's sheer scope and "kaleidoscopic narrative" worked to its detriment. [4] The Pittsburgh Post-Gazette felt it was "too ambitious", but a "heartening example of ... risk-taking" on Goldberg's part, emphasizing that the novel was nonetheless "very readable", and that Goldberg had included "powerful imagery, succinct prose and unabashed sensitivity". [6]
The Seattle Times considered the book "well-researched" but "somewhat elusive and not entirely satisfying", comparing it unfavorably to Goldberg's earlier work Bee Season . [7] Salon described it as "historically credible," and stated that "the real reason to read" the novel is "the chance to spend a few hours" with Lydia. [5]
A pandemic is an epidemic of an infectious disease that has a sudden increase in cases and spreads across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. Widespread endemic diseases with a stable number of infected individuals such as recurrences of seasonal influenza are generally excluded as they occur simultaneously in large regions of the globe rather than being spread worldwide.
An epidemic is the rapid spread of disease to a large number of hosts in a given population within a short period of time. For example, in meningococcal infections, an attack rate in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic.
The 1918–1920 flu pandemic, also known as the Great Influenza epidemic or by the common misnomer Spanish flu, was an exceptionally deadly global influenza pandemic caused by the H1N1 subtype of the influenza A virus. The earliest documented case was March 1918 in the state of Kansas in the United States, with further cases recorded in France, Germany and the United Kingdom in April. Two years later, nearly a third of the global population, or an estimated 500 million people, had been infected in four successive waves. Estimates of deaths range from 17 million to 50 million, and possibly as high as 100 million, making it one of the deadliest pandemics in history.
The Hong Kong flu, also known as the 1968 flu pandemic, was an influenza pandemic that occurred between 1968 and 1970 and which killed between one and four million people globally. It is among the deadliest pandemics in history, and was caused by an H3N2 strain of the influenza A virus. The virus was descended from H2N2 through antigenic shift, a genetic process in which genes from multiple subtypes are reassorted to form a new virus.
Swine influenza is an infection caused by any of several types of swine influenza viruses. Swine influenza virus (SIV) or swine-origin influenza virus (S-OIV) refers to any strain of the influenza family of viruses that is endemic in pigs. As of 2009, identified SIV strains include influenza C and the subtypes of influenza A known as H1N1, H1N2, H2N1, H3N1, H3N2, and H2N3.
Myla Goldberg is an American novelist and musician.
Flu season is an annually recurring time period characterized by the prevalence of an outbreak of influenza (flu). The season occurs during the cold half of the year in each hemisphere. It takes approximately two days to show symptoms. Influenza activity can sometimes be predicted and even tracked geographically. While the beginning of major flu activity in each season varies by location, in any specific location these minor epidemics usually take about three weeks to reach its pinnacle, and another three weeks to significantly diminish.
An influenza pandemic is an epidemic of an influenza virus that spreads across a large region and infects a large proportion of the population. There have been five major influenza pandemics in the last 140 years, with the 1918 flu pandemic being the most severe; this is estimated to have been responsible for the deaths of 50–100 million people. The 2009 swine flu pandemic resulted in under 300,000 deaths and is considered relatively mild. These pandemics occur irregularly.
Influenza, commonly known as the flu, is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin one to four days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia from the virus or a subsequent bacterial infection. Other complications include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease.
The 2009 swine flu pandemic, caused by the H1N1/swine flu/influenza virus and declared by the World Health Organization (WHO) from June 2009 to August 2010, was the third recent flu pandemic involving the H1N1 virus. The first identified human case was in La Gloria, Mexico, a rural town in Veracruz. The virus appeared to be a new strain of H1N1 that resulted from a previous triple reassortment of bird, swine, and human flu viruses which further combined with a Eurasian pig flu virus, leading to the term "swine flu".
The pandemic H1N1/09 virus is a swine origin influenza A virus subtype H1N1 strain that was responsible for the 2009 swine flu pandemic. This strain is often called swine flu by the public media due to the prevailing belief that it originated in pigs. The virus is believed to have originated around September 2008 in central Mexico.
The Great Influenza: The Story of the Deadliest Plague in History is a 2004 nonfiction book by John M. Barry that examines the Spanish flu, a 1918-1920 flu pandemic and one of the worst pandemics in history. Barry focuses on what was occurring in the United States at the time and attempts to place it against the background of American history and within the context of the history of medicine. The book describes how the flu started in Haskell County, Kansas, USA, and spread to the U.S. Army training camp Camp Funston, Kansas, USA, and around the world through troop movements during World War I.
The 1918 college football season was a season of college football in the United States. There was no consensus champion, with the Official NCAA Division I Football Records Book listing Michigan and Pittsburgh as national champions.
Howard Markel is an American physician and medical historian. At the end of 2023, Markel retired from the University of Michigan Medical School, where he served as the George E. Wantz Distinguished Professor of the History of Medicine and Director of the University's Center for the History of Medicine. He was also a professor of psychiatry, health management and policy, history, and pediatrics and communicable diseases. Markel writes extensively on major topics and figures in the history of medicine and public health.
During the 1972–1973 flu season in the Northern Hemisphere, a new variant of influenza, dubbed the 'London flu' by the press in the United States, was responsible for epidemics in many countries. 'London flu' was caused by a variant of influenza A/H3N2 that was first isolated in India in mid-1971 but only identified as a distinct strain in England in January, 1972.
The 1889–1890 pandemic, often referred to as the "Asiatic flu" or "Russian flu", was a worldwide respiratory viral pandemic. It was the last great pandemic of the 19th century, and is among the deadliest pandemics in history. The pandemic killed about 1 million people out of a world population of about 1.5 billion. The most reported effects of the pandemic took place from October 1889 to December 1890, with recurrences in March to June 1891, November 1891 to June 1892, the northern winter of 1893–1894, and early 1895.
The Philadelphia Liberty Loans Parade was a parade in Philadelphia, Pennsylvania, on September 28, 1918, organized to promote government bonds that helped pay for the needs of Allied troops in World War I. More than 200,000 Philadelphians attended the parade, which led to one of the largest outbreaks of the Spanish flu in the United States. It has since been declared the deadliest parade in American history.
The 1957–1958 Asian flu pandemic was a global pandemic of influenza A virus subtype H2N2 that originated in Guizhou in Southern China. The number of excess deaths caused by the pandemic is estimated to be 1–4 million around the world, making it one of the deadliest pandemics in history. A decade later, a reassorted viral strain H3N2 further caused the Hong Kong flu pandemic (1968–1970).
1918 flu pandemic in India was the outbreak of an unusually deadly influenza pandemic in British India between 1918 and 1920 as a part of the worldwide Spanish flu pandemic. Also referred to as the Bombay Influenza or the Bombay Fever in India, the pandemic is believed to have killed up to 17–18 million people in the country, the most among all countries. David Arnold (2019) estimates at least 12 million dead, about 5% of the population. The decade between 1911 and 1921 was the only census period in which India's population fell, mostly due to devastation of the Spanish flu pandemic. The death toll in India's British-ruled districts was 13.88 million.
The 1977 Russian flu was an influenza pandemic that was first reported by the Soviet Union in 1977 and lasted until 1979. The outbreak in northern China started in May 1977, slightly earlier than that in the Soviet Union. The pandemic mostly affected a population younger than 25 or 26 years of age, and was described as mild. It was caused by an H1N1 flu strain which highly resembled a virus strain circulating worldwide from 1946 to 1957.