Xiao Wang

Last updated
Xiao Wang
Alma mater Peking University, University of Chicago
Scientific career
Fields Chemistry
Institutions Massachusetts Institute of Technology
Academic advisors Chuan He
Website www.wangxiaolab.org

Xiao Wang is a Thomas D. and Virginia W. Cabot Professor at MIT in the Department of Chemistry. [1] She is the first Core Member of the Broad Institute with an academic appointment in the Department of Chemistry at MIT. [2] Her work focuses on designing and producing new tools and methods for analyzing the brain.

Contents

Education and career

Wang studied at Peking University and received her B.S. in chemistry and molecular engineering in 2010. At Peking University she studied with Professor Jian Pei working on fluorescent organic materials. In 2015 she received her Ph.D. from the University of Chicago where she worked with Chuan He on elucidating the cellular functions of RNA modifications. While at the University of Chicago, Wang was awarded the Chinese Government Award for Outstanding Self-Financed Students Abroad and the Elizabeth R. Norton Prize for Excellence in Research in Chemistry. [3] She was a postdoctoral fellow of the Life Sciences Foundation at Stanford University. She worked with Karl Deisseroth at Stanford and "developed comprehensive methods for analyzing RNA in intact tissues that merge sequencing with imaging, in order to reveal the locations of various cell types in the brain and to find out how these cells are connected." [4]

Wang became an assistant professor at MIT in 2019 and the Wang Lab at MIT opened on August 1, 2019. [5] In 2020 she was awarded a Searle Scholars Program grant. [6]

Selected publications

[7]

  1. J Liu*, Y Kim*, C E Richardson*, A Tom*, C Ramakrishnan, F Birey, T Katsumata, S Chen, C Wang, X Wang, L M Joubert, Y Jiang, H Wang, L E Fenno, J B H Tok, S P Pașca, K Shen, Z Bao#, K Deisseroth#. Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Science 2020, 367(6484), pp. 1372-1376.
  2. Y Liu*, J Liu*, S Chen, T Lei, Y Kim, S Niu, H Wang, X Wang, A M Foudeh, J B-H Tok, Z Bao#. Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation. Nature Biomedical Engineering 2019, 3, 58–68.
  3. X Wang*, W E Allen*, M Wright, E Sylwestrak, N Samusik, S Vesuna, K Evans, C Liu, C Ramakrishnan, J Liu, G P Nolan#, F-A Bava#, K Deisseroth#. Three-dimensional intact-tissue-sequencing of single-cell transcriptional states. Science 2018, eaat5691.
  4. I A Roundtree, G-Z Luo, Z Zhang, X Wang, T Zhou, Y Cui, J Sha, X Huang, L Guerrero, P Xie, E He, B Shen#, C He#. YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs. elife 2017,6, e31311
  5. H Shi*, X Wang*, Z Lu, B S Zhao, H Ma, P J Hsu, C He#. YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. Cell Research 2017, 27, 315.
  6. B S Zhao*, X Wang*, A V Beadell*, Z Lu, H Shi, A Kuuspalu, R K Ho#, C He#. m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition. Nature 2017, 542, 475.
  7. X Wang*, B S Zhao*, I A Roundtree, Z Lu, D Han, H Ma, X Weng, K Chen, H Shi, C He#. N6-methyladenosine modulates messenger RNA translation efficiency. Cell 2015, 161, 1388.

Related Research Articles

<span class="mw-page-title-main">FTO gene</span> Protein-coding gene in the species Homo sapiens

Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first mRNA demethylase that has been identified. Certain alleles of the FTO gene appear to be correlated with obesity in humans.

mir-17 microRNA precursor family

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families. These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA.

mir-1 microRNA precursor family

The miR-1 microRNA precursor is a small micro RNA that regulates its target protein's expression in the cell. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give products at ~22 nucleotides. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In humans there are two distinct microRNAs that share an identical mature sequence, and these are called miR-1-1 and miR-1-2.

<span class="mw-page-title-main">ZNRD1</span> Protein-coding gene in the species Homo sapiens

DNA-directed RNA polymerase I subunit RPA12 is an enzyme that in humans is encoded by the ZNRD1 gene.

mir-221 microRNA

In molecular biology, mir-221 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-138

miR-138 is a family of microRNA precursors found in animals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-138 precursor is the microRNA mir-138.

miR-214

miR-214 is a vertebrate-specific family of microRNA precursors. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.

<i>N</i><sup>6</sup>-Methyladenosine Modification in mRNA, DNA

N6-Methyladenosine (m6A) was originally identified and partially characterised in the 1970s, and is an abundant modification in mRNA and DNA. It is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA (snRNA) as well as several long non-coding RNA, such as Xist.

In molecular biology mir-340 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-25 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-25 levels increase in human heart failure, and treatment with an anti-sense RNA molecule (antagomiR) was recently reported to halt disease progression and improves cardiac function in a mouse heart failure model.

In molecular biology mir-638 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

<span class="mw-page-title-main">Chuan He</span> Chinese-American chemical biologist

Chuan He is a Chinese-American chemical biologist. He currently serves as the John T. Wilson Distinguished Service Professor at the University of Chicago, and an Investigator of the Howard Hughes Medical Institute. He is best known for his work in discovering and deciphering reversible RNA methylation in post-transcriptional gene expression regulation. He was awarded the 2023 Wolf Prize in Chemistry for his work in discovering and deciphering reversible RNA methylation in post-transcriptional gene expression regulation in addition to his contributions to the invention of TAB-seq, a biochemical method that can map 5-hydroxymethylcytosine (5hmC) at base-resolution genome-wide, as well as hmC-Seal, a method that covalently labels 5hmC for its detection and profiling.

mIR489 Non-coding RNA in the species Homo sapiens

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

<span class="mw-page-title-main">AlkB homolog 5, RNA demethylase</span> Protein-coding gene in the species Homo sapiens

RNA demethylase ALKBH5 is a protein that in humans is encoded by the ALKBH5 gene.

<span class="mw-page-title-main">MIR106A</span> Non-coding RNA in the species Homo sapiens

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene.

<span class="mw-page-title-main">YTHDF2</span> Protein-coding gene in the species Homo sapiens

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene.

Kang Zhang is a Chinese-American ophthalmologist specializing in ophthalmic genetics and aging processes in the eye. He is currently a Professor of the Faculty of Medicine at Macau University of Science and Technology. He was previously a Professor of Ophthalmology and the Founding Director of the Institute for Genomic Medicine at the University of California, San Diego. Zhang is particularly known for his work on lanosterol, stem cell research, gene editing, and artificial intelligence.

Xiang-Lei Yang (杨湘磊) is a Chinese-born American molecular biologist. She is a professor at The Scripps Research Institute, located in La Jolla, California. Her work has contributed to the establishment of physiological importance of aminoacyl-tRNA synthetases beyond their classical role in supporting mRNA translation and their disordered processes that contribute to disease. She founded the Translation Machinery in Health and Disease Gordon Research Conference, an ongoing biannual international conference since 2015. She helped co-found aTyr Pharma, a Nasdaq-listed biotechnology company.

CKLF-like MARVEL transmembrane domain-containing 5 (CMTM5), previously termed chemokine-like factor superfamily 5, designates any one of the six protein isoforms encoded by six different alternative splices of its gene, CMTM5; CMTM5-v1 is the most studied of these isoforms. The CMTM5 gene is located in band 11.2 on the long arm of chromosome 14.

The human identical sequence (HIS) is a sequence of RNA elements, 24-27 nucleotides in length, that coronavirus genomes share with the human genome. In pathogenic progression, HIS acts as a NamiRNA (nuclear activating miRNA) through the NamiRNA-enhancer network to activate neighboring host genes. The first HIS elements was identified in the SARS-CoV-2 genome, which has five HIS elements; other human coronaviruses have one to five. It has been suggested that these sequences can be more generally termed "host identical sequences" since similar correlations have been found between the genome of SARS-CoV-2 and multiple potential hosts (bats, pangolins, ferrets, and cats).

References

  1. ↑ "Xiao Wang – MIT Department of Chemistry" . Retrieved 2020-09-21.
  2. ↑ "Xiao Wang to Join the Faculty – MIT Department of Chemistry" . Retrieved 2020-09-21.
  3. ↑ "Graduate Student Awards | University of Chicago Department of Chemistry". chemistry.uchicago.edu. Retrieved 2020-09-21.
  4. ↑ "Xiao Wang". Broad Institute. 2019-08-09. Retrieved 2020-09-21.
  5. ↑ "Wang Lab". Wang Lab. Retrieved 2020-09-21.
  6. ↑ "Xiao Wang". Searle Scholars Program. Retrieved 2020-09-21.
  7. ↑ "Publication". Wang Lab. Retrieved 2020-09-21.
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