Yuman Fong is an American surgeon and scientist. He holds the Sangiacomo Chair in surgical oncology and is chairman of the department of surgery at the City of Hope Cancer Center. His early research was on immune activation during cancer or infection. [1] [2]
Fong's group is working on cell culture and cell-based production of biologics with the goal of making gene therapies, cell therapies, and vaccines affordable and accessible to all. [3]
He served as the Chair of the Recombinant DNA Advisory Committee (RAC) of the National Institutes of Health. [4] He is the founding Editor-in-Chief of Molecular Therapy Oncolytics (Cell Press, journal of ASGCT). [5] He is a member of the American Institute for Medical and Biological Engineering. [6]
He has co-authored over 1000 articles and 17 textbooks. PLOS Biology recognized Fong in 2019 as one of the most-cited researchers in the world. [7] Fong has been ranked by Google Scholar as one of the top 1000 most-cited researchers. [8] He has the number-one-cited paper in the history of the American Surgical Association. [9] He is editor of the Springer textbook on Image-guided Therapies and The SAGES Atlas in Robotic Surgery.
Fong was appointed an assistant professor to the faculty at Memorial Sloan-Kettering Cancer Center in 1993 with an academic appointment at Weill Cornell Medical Center. In 2000 he was promoted from assistant to full professor with tenure at Cornell University. [10] For over twenty years, he was an attending surgeon at the Memorial Sloan-Kettering Cancer Center (MSKCC), where he held the Murray F. Brennan Chair in Surgery.
In 2014, he left New York to return to California. He was appointed Chairman of the Department of Surgery at the City of Hope Medical Center. [11] There he held the Sangiacomo Family Chair in Surgical Oncology, named for Angelo and Yvonne Sangiacomo [12]
In 2021, he was elected a Member of the National Academy of Medicine. [13]
In vertebrates, the gallbladder, also known as the cholecyst, is a small hollow organ where bile is stored and concentrated before it is released into the small intestine. In humans, the pear-shaped gallbladder lies beneath the liver, although the structure and position of the gallbladder can vary significantly among animal species. It receives bile, produced by the liver, via the common hepatic duct, and stores it. The bile is then released via the common bile duct into the duodenum, where the bile helps in the digestion of fats.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%), PDGFRA gene (10%), or BRAF kinase (rare). 95% of GISTs stain positively for KIT (CD117). Most (66%) occur in the stomach and gastric GISTs have a lower malignant potential than tumors found elsewhere in the GI tract.
Cholecystectomy is the surgical removal of the gallbladder. Cholecystectomy is a common treatment of symptomatic gallstones and other gallbladder conditions. In 2011, cholecystectomy was the eighth most common operating room procedure performed in hospitals in the United States. Cholecystectomy can be performed either laparoscopically, or via an open surgical technique.
Cholangiocarcinoma, also known as bile duct cancer, is a type of cancer that forms in the bile ducts. Symptoms of cholangiocarcinoma may include abdominal pain, yellowish skin, weight loss, generalized itching, and fever. Light colored stool or dark urine may also occur. Other biliary tract cancers include gallbladder cancer and cancer of the ampulla of Vater.
A pancreaticoduodenectomy, also known as a Whipple procedure, is a major surgical operation most often performed to remove cancerous tumours from the head of the pancreas. It is also used for the treatment of pancreatic or duodenal trauma, or chronic pancreatitis. Due to the shared blood supply of organs in the proximal gastrointestinal system, surgical removal of the head of the pancreas also necessitates removal of the duodenum, proximal jejunum, gallbladder, and, occasionally, part of the stomach.
Hepatectomy is the surgical resection of the liver. While the term is often employed for the removal of the liver from a liver transplant donor, this article will focus on partial resections of hepatic tissue and hepatoportoenterostomy.
Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lung, and the rest of the body.
Markus Wolfgang Büchler is a German surgeon and university full professor. He specialises in gastrointestinal, hepatobiliary and transplant surgery, and is especially known for pioneering operations on the pancreas.
Nagy Habib is a British-Egyptian professor of hepato-biliary surgery at Imperial College, London, and is known for devising radio-frequency based liver resection devices which remove liver tumour with minimal blood loss. His work has also focused on stem cells and gene therapy.
Steven Kenneth Libutti, M.D., F.A.C.S. is an American surgeon and scientist. In January 2017, he became the third permanent Director of the Rutgers Cancer Institute of New Jersey, Vice Chancellor for Cancer Programs for Rutgers Biomedical and Health Sciences and the Senior Vice President for Oncology Services for RWJBarnabas Health, the largest health system in New Jersey. On October 17, 2024, Libutti was appointed the inaugural William N. Hait Director of the Rutgers Cancer Institute by the Rutgers University Board of Governors. He is a tenured Distinguished Professor of Surgery at the Rutgers Robert Wood Johnson Medical School. Libutti's work on the study of tumor angiogenesis and the tumor microenvironment has led to novel approaches for the treatment of cancer. He is also one of the pioneers of regional and targeted cancer therapy.
Hepatic arterial infusion (HAI) is a medical procedure that delivers chemotherapy directly to the liver. The procedure, mostly used in combination with systemic chemotherapy, plays a role in the treatment of liver metastases in patients with colorectal cancer (CRC). Although surgical resection remains the standard of care for these liver metastases, majority of patients have lesions that are unresectable.
Oncology is a branch of medicine that deals with the study, treatment, diagnosis, and prevention of cancer. A medical professional who practices oncology is an oncologist. The name's etymological origin is the Greek word ὄγκος (ónkos), meaning "tumor", "volume" or "mass". Oncology is concerned with:
The cystic node is the sentinel lymph node of the gall bladder. It is located within the cystohepatic triangle.
Clear-cell adenocarcinoma is a rare and aggressive form of cancer that typically arises in the female reproductive organs, particularly the ovaries and the endometrium as well as the kidneys and is characterized by the presence of clear, glycogen-rich cells. Specific criteria must be met for a tumor to be classified as clear cell adenocarcinoma. According to the WHO, these criteria include polygonal or hobnail or cells with clear or eosinophilic/oxyphilic cytoplasm and nuclear atypia, with different architectural patterns of growth, such as papillary, tubulocystic, or solid.
Alexey Nikolaevich Severtsev – a Russian doctor of medicine sciences, professor in the hospital surgery department of the medical faculty in Pirogov Russian National Research Medical University and the chief surgeon of a chain of clinics “MEDSI”.
Imugene Ltd is a clinical stage immuno-oncology company developing a range of new and novel immunotherapies that seek to activate the immune system of cancer patients to treat and eradicate tumours. Imugene's unique platform technologies seeks to harness the body's immune system against tumours, potentially achieving a similar or greater effect than synthetically manufactured monoclonal antibody and other immunotherapies.
AME Publishing Company is an academic publishing company, which publishes medical journals and books. Founded in July 2009, it is currently headquartered in Hong Kong, with additional offices in Guangzhou, Changsha, Nanjing, Shanghai, Chengdu, Beijing, Taipei, and Hangzhou. Its name stands for "Academic Made Easy/Excellent/Enthusiastic". It has published over 50 medical journals, as well as 20 English-language books, 28 Chinese-language books, and 60 e-books.
Jeffrey Drebin is a surgeon and scientist. He serves as the Department of Surgery Chair at Memorial Sloan Kettering.
Multimodal cancer therapy, often referred to simply as multimodal therapy or multimodal cancer care, is an approach for treatment of cancer that combines radiation and chemotherapy or other multiple therapeutic modalities. For example, in the case of mesotheliomas, treatments combine modalities such as surgery, chemotherapy, immunotherapy, and radiotherapy. Multimodal treatments can often have synergistic effects leading to better clinical outcomes.
Timothy Michael Pawlik is an American surgical oncologist. He is the Chair of the Department of Surgery and the Urban Meyer III and Shelley Meyer Chair for Cancer Research at Ohio State University and Surgeon-in-Chief at the Ohio State University Wexner Medical Center.
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