YybP-ykoY leader

Last updated
yybP-ykoY leader
RF00080.jpg
Predicted secondary structure and sequence conservation of yybP-ykoY
Identifiers
SymbolyybP-ykoY
Alt. SymbolsSraF
Rfam RF00080
Other data
RNA type Cis-reg; riboswitch
Domain Bacteria
SO SO:0000233
PDB structures PDBe

The yybP-ykoY leader RNA element was originally discovered in E. coli during a large scale screen and was named SraF. [1] This family was later found to exist upstream of related families of protein genes in many bacteria, including the yybP and ykoY genes in B. subtilis . The specific functions of these proteins are unknown, but this structured RNA element may be involved in their genetic regulation as a riboswitch. [2] The yybP-ykoY element was later proposed to be manganese-responsive after another associated family of genes, YebN/MntP, was shown to encode Mn2+ efflux pumps in several bacteria. [3] [4] [5] Genetic data and a crystal structure confirmed that yybp-ykoY is a manganese riboswitch that directly binds Mn2+ [6] [7]

References

  1. ↑ Argaman L, Hershberg R, Vogel J, Bejerano G, Wagner EG, Margalit H, Altuvia S (June 2001). "Novel small RNA-encoding genes in the intergenic regions of Escherichia coli". Current Biology. 11 (12): 941–950. doi: 10.1016/S0960-9822(01)00270-6 . PMID   11448770.
  2. ↑ Barrick JE, Corbino KA, Winkler WC, Nahvi A, Mandal M, Collins J, Lee M, Roth A, Sudarsan N, Jona I, Wickiser JK, Breaker RR (April 2004). "New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control". Proceedings of the National Academy of Sciences of the United States of America. 101 (17): 6421–6426. Bibcode:2004PNAS..101.6421B. doi: 10.1073/pnas.0308014101 . PMC   404060 . PMID   15096624.
  3. ↑ Waters LS, Sandoval M, Storz G (November 2011). "The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis". Journal of Bacteriology. 193 (21): 5887–5897. doi:10.1128/jb.05872-11. PMC   3194919 . PMID   21908668.
  4. ↑ Li C, Tao J, Mao D, He C (2011). "A novel manganese efflux system, YebN, is required for virulence by Xanthomonas oryzae pv. oryzae". PLOS ONE. 6 (7) e21983. Bibcode:2011PLoSO...621983L. doi: 10.1371/journal.pone.0021983 . PMC   3136493 . PMID   21789199.
  5. ↑ Veyrier FJ, Boneca IG, Cellier MF, Taha MK (September 2011). "A novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and Neisseria meningitidis virulence". PLOS Pathogens. 7 (9) e1002261. doi: 10.1371/journal.ppat.1002261 . PMC   3182930 . PMID   21980287.
  6. ↑ Price IR, Gaballa A, Ding F, Helmann JD, Ke A (March 2015). "Mn(2+)-sensing mechanisms of yybP-ykoY orphan riboswitches". Molecular Cell. 57 (6): 1110–1123. doi:10.1016/j.molcel.2015.02.016. PMC   4703321 . PMID   25794619.
  7. ↑ Dambach M, Sandoval M, Updegrove TB, Anantharaman V, Aravind L, Waters LS, Storz G (March 2015). "The ubiquitous yybP-ykoY riboswitch is a manganese-responsive regulatory element". Molecular Cell. 57 (6): 1099–1109. doi:10.1016/j.molcel.2015.01.035. PMC   4376352 . PMID   25794618.
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