Allan Bradley

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Allan Bradley
Professor Sir Allan Bradley, Founder & Chief Scientific Officer at the launch of the Shakespeare Review (8740129867).jpg
Allan Bradley at the launch of the Shakespeare review, organised by Policy Exchange
Born
Allan Bradley
Alma mater University of Cambridge (BA, MA, PhD) [1]
Known for Embryonic stem cells [2]
Awards
Scientific career
Fields Mouse genomics [4] [5] [6] [7] [8]
Institutions
Thesis Isolation characterisation and developmental potential of murine embryo-derived stem cells  (1986)
Doctoral advisor Martin Evans [9] [10]
Website sanger.ac.uk/person/bradley-allan/

Allan Bradley FRS is a British geneticist at the Wellcome Trust Sanger Institute. [11] [12] [13] [14]

Contents

Education

Bradley was educated at the University of Cambridge where he earned Bachelor of Arts, Master of Arts and PhD [15] degrees in genetics from Trinity College, Cambridge gained while working in the laboratory of Martin Evans. [1] [9]

Career

Following his PhD, Bradley was appointed assistant professor at Baylor College of Medicine, beginning in 1987 where he was also a Searle Scholar in 1988. [16] Bradley was appointed a Howard Hughes Medical Institute Investigator in 1993 and director of the Wellcome Trust Sanger Institute, from October 2000 (preceded by John Sulston) to April 2010, succeeded by Michael Stratton.

Awards and honours

Bradley won a 1994 DeBakey Award [17] and was elected a Fellow of the Royal Society (FRS) in 2002. His certificate of election reads:

"Allan Bradley has made important contributions to the technique of mutation of endogenous genes in mice, an approach that has opened up a new era of research in biology. It is impossible to open an issue of a major journal nowadays without coming across an article that describes the consequences of mutating an endogenous gene in mice. The generation of these mice is based on concepts and techniques that can be traced back to experiments performed and published by Bradley fifteen years ago. In the years since, he has not only used ES cell technology to provide key information on the functions of many genes including several important tumour suppressor genes, but has also continued to improve and develop the techniques, technology, and tools for genetic manipulation in the mouse. Today, mice can be generated with changes as subtle as an alteration in a single nucleotide or as extensive as the deletion of millions of base pairs. These alterations will gain increasing importance in genetic experiments aimed at understanding the function of genes in the mammalian genome in the post genome era." [2]

Related Research Articles

<span class="mw-page-title-main">Martin Evans</span> British biologist

Sir Martin John EvansFLSW is an English biologist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981. He is also known, along with Mario Capecchi and Oliver Smithies, for his work in the development of the knockout mouse and the related technology of gene targeting, a method of using embryonic stem cells to create specific gene modifications in mice. In 2007, the three shared the Nobel Prize in Physiology or Medicine in recognition of their discovery and contribution to the efforts to develop new treatments for illnesses in humans.

<span class="mw-page-title-main">Wellcome Sanger Institute</span> British genomics research institute

The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust.

<span class="mw-page-title-main">ADAM17</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloprotease 17 (ADAM17), also called TACE, is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases.

<span class="mw-page-title-main">TRPC4AP</span> Protein-coding gene in the species Homo sapiens

Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.

<span class="mw-page-title-main">SPTBN1</span> Protein-coding gene in the species Homo sapiens

Spectrin beta chain, brain 1 is a protein that in humans is encoded by the SPTBN1 gene.

<span class="mw-page-title-main">RAD18</span> Protein-coding gene in the species Homo sapiens

E3 ubiquitin-protein ligase RAD18 is an enzyme that in humans is encoded by the RAD18 gene.

<span class="mw-page-title-main">BAZ1B</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein kinase, or Bromodomain adjacent to zinc finger domain, 1B (BAZ1B) is an enzyme that in humans is encoded by the BAZ1B gene.

<span class="mw-page-title-main">LRIG1</span> Protein-coding gene in the species Homo sapiens

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR family and with MET and RET.

<span class="mw-page-title-main">Shugoshin 2</span> Protein-coding gene in the species Homo sapiens

Shugoshin 2(Shugoshin-2), also known as Shugoshin-like 2, is a protein which in humans is encoded by the SGO2 gene.

<span class="mw-page-title-main">ASXL1</span> Protein-coding gene in the species Homo sapiens

Putative Polycomb group protein ASXL1 is a protein that in humans is encoded by the ASXL1 gene.

<span class="mw-page-title-main">Ninein-like protein</span> Protein found in humans

Ninein-like protein is a protein that in humans is encoded by the NINL gene. It is part of the centrosome.

<span class="mw-page-title-main">ARHGEF4</span> Protein-coding gene in the species Homo sapiens

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.

<span class="mw-page-title-main">TRAFD1</span> Protein-coding gene in the species Homo sapiens

TRAF-type zinc finger domain-containing protein 1 is a protein that in humans is encoded by the TRAFD1 gene.

<span class="mw-page-title-main">SLX4</span> Protein involved in DNA repair

SLX4 is a protein involved in DNA repair, where it has important roles in the final steps of homologous recombination. Mutations in the gene are associated with the disease Fanconi anemia.

Sir Michael Rudolf Stratton, is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Consortium.

<span class="mw-page-title-main">COQ9</span> Protein-coding gene in humans

Ubiquinone biosynthesis protein COQ9, mitochondrial, also known as coenzyme Q9 homolog (COQ9), is a protein that in humans is encoded by the COQ9 gene.

<i>BBX</i> (gene) Human protein-coding gene

HMG box transcription factor BBX also known as bobby sox homolog or HMG box-containing protein 2 is a protein that in humans is encoded by the BBX gene.

Glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial) is a protein that in humans is encoded by the GATC gene. The gene is also known as 15E1.2 and encodes part of a Glu-tRNA(Gln) amidotransferase enzyme.

RIKEN cDNA 4932414N04 is a protein that in the house mouse is encoded by the 4932414N04Rik gene. The gene is also known as RP23-459M13.1.

<span class="mw-page-title-main">Elizabeth Robertson</span> British geneticist

Elizabeth Jane Robertson is a British developmental biologist based at the Sir William Dunn School of Pathology, University of Oxford. She is Professor of Developmental Biology at Oxford and a Wellcome Trust Principal Research Fellow. She is best known for her pioneering work in developmental genetics, showing that genetic mutations could be introduced into the mouse germ line by using genetically altered embryonic stem cells. This discovery opened up a major field of experimentation for biologists and clinicians.

References

  1. 1 2 "BRADLEY, Prof. Allan" . Who's Who . Vol. 2014 (online Oxford University Press  ed.). A & C Black.(Subscription or UK public library membership required.)
  2. 1 2 "Certificate of election EC/2002/01: Allan Bradley". London: The Royal Society. Archived from the original on 3 September 2015. Retrieved 14 November 2013.
  3. ↑ "The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from the original on 16 March 2015.
  4. ↑ Donehower, L. A.; Harvey, M.; Slagle, B. L.; McArthur, M. J.; Montgomery Jr, C. A.; Butel, J. S.; Bradley, A. (1992). "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours". Nature. 356 (6366): 215–221. Bibcode:1992Natur.356..215D. doi:10.1038/356215a0. PMID   1552940. S2CID   4348340.
  5. ↑ Dalton, D.; Pitts-Meek, S.; Keshav, S.; Figari, I.; Bradley, A.; Stewart, T. (1993). "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes". Science. 259 (5102): 1739–1742. Bibcode:1993Sci...259.1739D. doi:10.1126/science.8456300. PMID   8456300.
  6. ↑ Guo, G.; Wang, W.; Bradley, A. (2004). "Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells". Nature. 429 (6994): 891–895. Bibcode:2004Natur.429..891G. doi:10.1038/nature02653. PMID   15215866. S2CID   2545884.
  7. ↑ Kile, B. T.; Hentges, K. E.; Clark, A. T.; Nakamura, H.; Salinger, A. P.; Liu, B.; Box, N.; Stockton, D. W.; Johnson, R. L.; Behringer, R. R.; Bradley, A.; Justice, M. J. (2003). "Functional genetic analysis of mouse chromosome 11". Nature. 425 (6953): 81–86. Bibcode:2003Natur.425...81K. doi:10.1038/nature01865. PMID   12955145. S2CID   4409237.
  8. ↑ "Mouse genomics – Allan Bradley laboratory". Wellcome Trust Sanger Institute. Archived from the original on 1 April 2010.
  9. 1 2 "Allan Bradley – Wellcome Trust Sanger Institute". Sanger.ac.uk. Archived from the original on 13 November 2013.
  10. ↑ Watts, Geoff (2007). "Martin Evans: joint winner of 2007 Nobel Prize in medicine". The Lancet. 370 (9605): 2095. doi:10.1016/S0140-6736(07)61889-3. ISSN   0140-6736. PMID   18156018. S2CID   7800773.
  11. ↑ "Professor Allan Bradley: a decade at Sanger | Wellcome Trust". Wellcome.ac.uk. 15 June 2010. Archived from the original on 3 December 2010. Retrieved 4 April 2012.
  12. ↑ "Wellcome Trust Sanger Institute's Director Honoured: Allan Bradley Elected to Royal Society – Wellcome Trust Sanger Institute". Sanger.ac.uk. Retrieved 4 April 2012.
  13. ↑ Allan Bradley's publications indexed by the Scopus bibliographic database. (subscription required)
  14. ↑ Kate Kelland (12 October 2011). "New stem cell method could end need for liver transplants". National Post.
  15. ↑ Bradley, A. (1985). Isolation characterization and developmental potential of murine embryo-derived stem cells (PhD thesis). University of Cambridge.
  16. ↑ "Searle Scholars Program: Allan Bradley (1988)". Searlescholars.net. Retrieved 4 April 2012.
  17. ↑ "Bradley – DeBakey Excellence in Research Awards- Baylor College of Medicine, Houston, Texas". Bcm.edu. Archived from the original on 19 July 2012. Retrieved 4 April 2012.
Non-profit organization positions
Preceded by Director of the Wellcome Trust Sanger Institute
2000–2010		Succeeded by
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