CRISP1

CRISP1
Identifiers
Aliases	CRISP1 , AEGL1, ARP, CRISP-1, HSCRISP1D, HSCRISP1G, HUMARP, HEL-S-57, cysteine rich secretory protein 1
External IDs	OMIM: 601193 MGI: 1925331 HomoloGene: 81683 GeneCards: CRISP1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p12.3 Start 49,834,257 bp [1] End 49,877,096 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 A3 Start 18,185,415 bp [2] End 18,216,126 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis sperm seminal vesicula caput epididymis endometrium head mouth salivary gland intestinal epithelium minor salivary gland Top expressed in spermatid white adipose tissue nucleus of brain male reproductive system telencephalic nucleus testicle hypothalamus brain stem midbrain tegmentum cerebral hemisphere More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium channel regulator activity Cellular component extracellular region nucleus extracellular space Biological process fusion of sperm to egg plasma membrane involved in single fertilization regulation of acrosome reaction binding of sperm to zona pellucida regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 167 78081 Ensembl ENSG00000124812 ENSMUSG00000025774 UniProt P54107 n/a RefSeq (mRNA) NM_001131 NM_001205220 NM_170609 NM_030033 NM_001347047 NM_001347048 RefSeq (protein) NP_001122 NP_001192149 NP_733758 n/a Location (UCSC) Chr 6: 49.83 – 49.88 Mb Chr 1: 18.19 – 18.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cysteine-rich secretory protein 1 is a cysteine-rich secretory protein that in humans is encoded by the CRISP1 gene. ^{[5] [6]}

Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. This protein is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head where it plays a role at fertilization in sperm-egg fusion through complementary sites localized on the egg surface. Two isoforms are encoded by transcript variants of this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000124812 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025774 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hayashi M, Fujimoto S, Takano H, Ushiki T, Abe K, Ishikura H, Yoshida MC, Kirchhoff C, Ishibashi T, Kasahara M (Feb 1997). "Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1)". Genomics. 32 (3): 367–74. doi:10.1006/geno.1996.0131. PMID   8838800.
6. "Entrez Gene: CRISP1 cysteine-rich secretory protein 1".

External links

• Human CRISP1 genome location and CRISP1 gene details page in the UCSC Genome Browser .

Further reading

• Kirchhoff C (1998). "Molecular characterization of epididymal proteins". Rev. Reprod. 3 (2): 86–95. doi: 10.1530/ror.0.0030086 . PMID   9685187.
• Cuasnicú PS, Ellerman DA, Cohen DJ, et al. (2002). "Molecular mechanisms involved in mammalian gamete fusion". Arch. Med. Res. 32 (6): 614–8. doi:10.1016/S0188-4409(01)00321-6. hdl: 11336/31335 . PMID   11750738.
• Evans JP (2003). "The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization". Hum. Reprod. Update. 8 (4): 297–311. doi:10.1093/humupd/8.4.297. PMID   12206465.
• Hayashi M (1996). "[Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization]". Hokkaido Igaku Zasshi. 70 (5): 743–53. PMID   8543280.
• Krätzschmar J, Haendler B, Eberspaecher U, et al. (1996). "The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3". Eur. J. Biochem. 236 (3): 827–36. doi: 10.1111/j.1432-1033.1996.t01-1-00827.x . PMID   8665901.
• Cohen DJ, Ellerman DA, Busso D, et al. (2001). "Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg". Biol. Reprod. 65 (4): 1000–5. doi:10.1095/biolreprod65.4.1000. hdl: 11336/31337 . PMID   11566719. S2CID   2498686.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.